Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin
Aims/hypothesis Individuals carrying variants of the transcription factor 7-like 2 gene (TCF7L2) are at increased risk for type 2 diabetes. These metabolic genetic risk factors have been linked to diminished pancreatic islet-cell responsiveness to incretins, thus pharmacological interventions aim...
Main Authors: | Graefe-Mody, Ulrike, Boehm, Bernhard O., Mark, Michael, Zimdahl, Heike, Ittrich, Carina, Woerle, Hans-Juergen, Dugi, Klaus A. |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Journal Article |
Language: | English |
Published: |
2014
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/105881 http://hdl.handle.net/10220/20950 |
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