Ultrasound-mediated drug/gene delivery in solid tumor treatment
Ultrasound is an emerging modality for drug delivery in chemotherapy. This paper reviews this novel technology by first introducing the designs and characteristics of three classes of drug/gene vehicles, microbubble (including nanoemulsion), liposomes, and micelles. In comparison to conventional fre...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
|
| Online Access: | https://hdl.handle.net/10356/105919 http://hdl.handle.net/10220/17771 http://dx.doi.org/10.1260/2040-2295.4.2.223 |
| _version_ | 1826114761306144768 |
|---|---|
| author | Zhou, Yufeng. |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Zhou, Yufeng. |
| author_sort | Zhou, Yufeng. |
| collection | NTU |
| description | Ultrasound is an emerging modality for drug delivery in chemotherapy. This paper reviews this novel technology by first introducing the designs and characteristics of three classes of drug/gene vehicles, microbubble (including nanoemulsion), liposomes, and micelles. In comparison to conventional free drug, the targeted drug-release and delivery through vessel wall and interstitial space to cancerous cells can be activated and enhanced under certain sonication conditions. In the acoustic field, there are several reactions of these drug vehicles, including hyperthermia, bubble cavitation, sonoporation, and sonodynamics, whose physical properties are illustrated for better understanding of this approach. In vitro and in vivo results are summarized, and future directions are discussed. Altogether, ultrasound-mediated drug/gene delivery under imaging guidance provides a promising option in cancer treatment with enhanced agent release and site specificity and reduced toxicity. |
| first_indexed | 2024-10-01T03:44:26Z |
| format | Journal Article |
| id | ntu-10356/105919 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:44:26Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/1059192019-12-06T22:00:40Z Ultrasound-mediated drug/gene delivery in solid tumor treatment Zhou, Yufeng. School of Mechanical and Aerospace Engineering Ultrasound is an emerging modality for drug delivery in chemotherapy. This paper reviews this novel technology by first introducing the designs and characteristics of three classes of drug/gene vehicles, microbubble (including nanoemulsion), liposomes, and micelles. In comparison to conventional free drug, the targeted drug-release and delivery through vessel wall and interstitial space to cancerous cells can be activated and enhanced under certain sonication conditions. In the acoustic field, there are several reactions of these drug vehicles, including hyperthermia, bubble cavitation, sonoporation, and sonodynamics, whose physical properties are illustrated for better understanding of this approach. In vitro and in vivo results are summarized, and future directions are discussed. Altogether, ultrasound-mediated drug/gene delivery under imaging guidance provides a promising option in cancer treatment with enhanced agent release and site specificity and reduced toxicity. 2013-11-19T04:05:49Z 2019-12-06T22:00:40Z 2013-11-19T04:05:49Z 2019-12-06T22:00:40Z 2013 2013 Journal Article Zhou, Y. (2013). Ultrasound-Mediated Drug/Gene Delivery in Solid Tumor Treatment. Journal of Healthcare Engineering, 4(2), 223-254. 2040-2295 https://hdl.handle.net/10356/105919 http://hdl.handle.net/10220/17771 http://dx.doi.org/10.1260/2040-2295.4.2.223 en Journal of healthcare engineering |
| spellingShingle | Zhou, Yufeng. Ultrasound-mediated drug/gene delivery in solid tumor treatment |
| title | Ultrasound-mediated drug/gene delivery in solid tumor treatment |
| title_full | Ultrasound-mediated drug/gene delivery in solid tumor treatment |
| title_fullStr | Ultrasound-mediated drug/gene delivery in solid tumor treatment |
| title_full_unstemmed | Ultrasound-mediated drug/gene delivery in solid tumor treatment |
| title_short | Ultrasound-mediated drug/gene delivery in solid tumor treatment |
| title_sort | ultrasound mediated drug gene delivery in solid tumor treatment |
| url | https://hdl.handle.net/10356/105919 http://hdl.handle.net/10220/17771 http://dx.doi.org/10.1260/2040-2295.4.2.223 |
| work_keys_str_mv | AT zhouyufeng ultrasoundmediateddruggenedeliveryinsolidtumortreatment |