Spread of artemisinin resistance in plasmodium falciparum malaria
BACKGROUND: Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria. Mapping the geographic extent of resistance is essential for planning containment and elimination strategies. METHODS: Between May 2011 and Apri...
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| Format: | Journal Article |
| Language: | English |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/106044 http://hdl.handle.net/10220/26243 |
| _version_ | 1811678868058144768 |
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| author | Tripura, Rupam Borrmann, Steffen Bashraheil, Mahfudh Peshu, Judy Faiz, M. Abul Ghose, Aniruddha Hossain, M. Amir Samad, Rasheda Rahman, M. Ridwanur Valecha, Neena Phyo, Aung Pyae Venkatesan, Meera Mishra, Neelima Yi, Poravuth Ashley, Elizabeth A. Dhorda, Mehul Fairhurst, Rick M. Amaratunga, Chanaki Lim, Parath Suon, Seila Sreng, Sokunthea Anderson, Jennifer M. Mao, Sivanna Sam, Baramey Sopha, Chantha Chuor, Char Meng Nguon, Chea Sovannaroth, Siv Pukrittayakamee, Sasithon Jittamala, Podjanee Chotivanich, Kesinee Chutasmit, Kitipumi Suchatsoonthorn, Chaiyaporn Runcharoen, Ratchadaporn Hien, Tran Tinh Thuy-Nhien, Nguyen Thanh Thanh, Ngo Viet Phu, Nguyen Hoan Htut, Ye Han, Kay-Thwe Aye, Kyin Hla Mokuolu, Olugbenga A. Olaosebikan, Rasaq R. Folaranmi, Olaleke O. Mayxay, Mayfong Khanthavong, Maniphone Hongvanthong, Bouasy Newton, Paul N. Onyamboko, Marie A. Fanello, Caterina I. Tshefu, Antoinette K. Nosten, Francois Hasan, M. Mahtabuddin Islam, Akhterul Miotto, Olivo Amato, Roberto MacInnis, Bronwyn Stalker, Jim Kwiatkowski, Dominic P. Bozdech, Zbynek Jeeyapant, Atthanee Cheah, Phaik Yeong Sakulthaew, Tharisara Chalk, Jeremy Intharabut, Benjamas Silamut, Kamolrat Lee, Sue J. Vihokhern, Benchawan Kunasol, Chanon Imwong, Mallika Tarning, Joel Taylor, Walter J. Yeung, Shunmay Woodrow, Charles J. Flegg, Jennifer A. Das, Debashish Smith, Jeffery Plowe, Christopher V. Stepniewska, Kasia Guerin, Philippe J. Dondorp, Arjen M. Day, Nicholas P. White, Nicholas J. |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Tripura, Rupam Borrmann, Steffen Bashraheil, Mahfudh Peshu, Judy Faiz, M. Abul Ghose, Aniruddha Hossain, M. Amir Samad, Rasheda Rahman, M. Ridwanur Valecha, Neena Phyo, Aung Pyae Venkatesan, Meera Mishra, Neelima Yi, Poravuth Ashley, Elizabeth A. Dhorda, Mehul Fairhurst, Rick M. Amaratunga, Chanaki Lim, Parath Suon, Seila Sreng, Sokunthea Anderson, Jennifer M. Mao, Sivanna Sam, Baramey Sopha, Chantha Chuor, Char Meng Nguon, Chea Sovannaroth, Siv Pukrittayakamee, Sasithon Jittamala, Podjanee Chotivanich, Kesinee Chutasmit, Kitipumi Suchatsoonthorn, Chaiyaporn Runcharoen, Ratchadaporn Hien, Tran Tinh Thuy-Nhien, Nguyen Thanh Thanh, Ngo Viet Phu, Nguyen Hoan Htut, Ye Han, Kay-Thwe Aye, Kyin Hla Mokuolu, Olugbenga A. Olaosebikan, Rasaq R. Folaranmi, Olaleke O. Mayxay, Mayfong Khanthavong, Maniphone Hongvanthong, Bouasy Newton, Paul N. Onyamboko, Marie A. Fanello, Caterina I. Tshefu, Antoinette K. Nosten, Francois Hasan, M. Mahtabuddin Islam, Akhterul Miotto, Olivo Amato, Roberto MacInnis, Bronwyn Stalker, Jim Kwiatkowski, Dominic P. Bozdech, Zbynek Jeeyapant, Atthanee Cheah, Phaik Yeong Sakulthaew, Tharisara Chalk, Jeremy Intharabut, Benjamas Silamut, Kamolrat Lee, Sue J. Vihokhern, Benchawan Kunasol, Chanon Imwong, Mallika Tarning, Joel Taylor, Walter J. Yeung, Shunmay Woodrow, Charles J. Flegg, Jennifer A. Das, Debashish Smith, Jeffery Plowe, Christopher V. Stepniewska, Kasia Guerin, Philippe J. Dondorp, Arjen M. Day, Nicholas P. White, Nicholas J. |
| author_sort | Tripura, Rupam |
| collection | NTU |
| description | BACKGROUND: Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria. Mapping the geographic extent of resistance is essential for planning containment and elimination strategies. METHODS: Between May 2011 and April 2013, we enrolled 1241 adults and children with acute, uncomplicated falciparum malaria in an open-label trial at 15 sites in 10 countries (7 in Asia and 3 in Africa). Patients received artesunate, administered orally at a daily dose of either 2 mg per kilogram of body weight per day or 4 mg per kilogram, for 3 days, followed by a standard 3-day course of artemisinin-based combination therapy. Parasite counts in peripheral-blood samples were measured every 6 hours, and the parasite clearance half-lives were determined. RESULTS: The median parasite clearance half-lives ranged from 1.9 hours in the Democratic Republic of Congo to 7.0 hours at the Thailand-Cambodia border. Slowly clearing infections (parasite clearance half-life >5 hours), strongly associated with single point mutations in the "propeller" region of the P. falciparum kelch protein gene on chromosome 13 (kelch13), were detected throughout mainland Southeast Asia from southern Vietnam to central Myanmar. The incidence of pretreatment and post-treatment gametocytemia was higher among patients with slow parasite clearance, suggesting greater potential for transmission. In western Cambodia, where artemisinin-based combination therapies are failing, the 6-day course of antimalarial therapy was associated with a cure rate of 97.7% (95% confidence interval, 90.9 to 99.4) at 42 days. CONCLUSIONS: Artemisinin resistance to P. falciparum, which is now prevalent across mainland Southeast Asia, is associated with mutations in kelch13. Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing. |
| first_indexed | 2024-10-01T03:00:06Z |
| format | Journal Article |
| id | ntu-10356/106044 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:00:06Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | ntu-10356/1060442023-02-28T17:04:53Z Spread of artemisinin resistance in plasmodium falciparum malaria Tripura, Rupam Borrmann, Steffen Bashraheil, Mahfudh Peshu, Judy Faiz, M. Abul Ghose, Aniruddha Hossain, M. Amir Samad, Rasheda Rahman, M. Ridwanur Valecha, Neena Phyo, Aung Pyae Venkatesan, Meera Mishra, Neelima Yi, Poravuth Ashley, Elizabeth A. Dhorda, Mehul Fairhurst, Rick M. Amaratunga, Chanaki Lim, Parath Suon, Seila Sreng, Sokunthea Anderson, Jennifer M. Mao, Sivanna Sam, Baramey Sopha, Chantha Chuor, Char Meng Nguon, Chea Sovannaroth, Siv Pukrittayakamee, Sasithon Jittamala, Podjanee Chotivanich, Kesinee Chutasmit, Kitipumi Suchatsoonthorn, Chaiyaporn Runcharoen, Ratchadaporn Hien, Tran Tinh Thuy-Nhien, Nguyen Thanh Thanh, Ngo Viet Phu, Nguyen Hoan Htut, Ye Han, Kay-Thwe Aye, Kyin Hla Mokuolu, Olugbenga A. Olaosebikan, Rasaq R. Folaranmi, Olaleke O. Mayxay, Mayfong Khanthavong, Maniphone Hongvanthong, Bouasy Newton, Paul N. Onyamboko, Marie A. Fanello, Caterina I. Tshefu, Antoinette K. Nosten, Francois Hasan, M. Mahtabuddin Islam, Akhterul Miotto, Olivo Amato, Roberto MacInnis, Bronwyn Stalker, Jim Kwiatkowski, Dominic P. Bozdech, Zbynek Jeeyapant, Atthanee Cheah, Phaik Yeong Sakulthaew, Tharisara Chalk, Jeremy Intharabut, Benjamas Silamut, Kamolrat Lee, Sue J. Vihokhern, Benchawan Kunasol, Chanon Imwong, Mallika Tarning, Joel Taylor, Walter J. Yeung, Shunmay Woodrow, Charles J. Flegg, Jennifer A. Das, Debashish Smith, Jeffery Plowe, Christopher V. Stepniewska, Kasia Guerin, Philippe J. Dondorp, Arjen M. Day, Nicholas P. White, Nicholas J. School of Biological Sciences DRNTU::Science::Biological sciences::Microbiology BACKGROUND: Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria. Mapping the geographic extent of resistance is essential for planning containment and elimination strategies. METHODS: Between May 2011 and April 2013, we enrolled 1241 adults and children with acute, uncomplicated falciparum malaria in an open-label trial at 15 sites in 10 countries (7 in Asia and 3 in Africa). Patients received artesunate, administered orally at a daily dose of either 2 mg per kilogram of body weight per day or 4 mg per kilogram, for 3 days, followed by a standard 3-day course of artemisinin-based combination therapy. Parasite counts in peripheral-blood samples were measured every 6 hours, and the parasite clearance half-lives were determined. RESULTS: The median parasite clearance half-lives ranged from 1.9 hours in the Democratic Republic of Congo to 7.0 hours at the Thailand-Cambodia border. Slowly clearing infections (parasite clearance half-life >5 hours), strongly associated with single point mutations in the "propeller" region of the P. falciparum kelch protein gene on chromosome 13 (kelch13), were detected throughout mainland Southeast Asia from southern Vietnam to central Myanmar. The incidence of pretreatment and post-treatment gametocytemia was higher among patients with slow parasite clearance, suggesting greater potential for transmission. In western Cambodia, where artemisinin-based combination therapies are failing, the 6-day course of antimalarial therapy was associated with a cure rate of 97.7% (95% confidence interval, 90.9 to 99.4) at 42 days. CONCLUSIONS: Artemisinin resistance to P. falciparum, which is now prevalent across mainland Southeast Asia, is associated with mutations in kelch13. Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing. Published version 2015-07-03T03:37:29Z 2019-12-06T22:03:33Z 2015-07-03T03:37:29Z 2019-12-06T22:03:33Z 2014 2014 Journal Article Ashley, E. A., Dhorda, M., Fairhurst, R. M., Amaratunga, C., Lim, P., Suon, S., et al. (2014). Spread of artemisinin resistance in plasmodium falciparum malaria. New England journal of medicine, 371(5), 411-423. https://hdl.handle.net/10356/106044 http://hdl.handle.net/10220/26243 10.1056/NEJMoa1314981 25075834 en New England journal of medicine © 2014 Massachusetts Medical Society. This paper was published in The New England Journal of Medicine and is made available as an electronic reprint (preprint) with permission of Massachusetts Medical Society. The published version is available at: [http://dx.doi.org/10.1056/NEJMoa1314981]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 14 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Microbiology Tripura, Rupam Borrmann, Steffen Bashraheil, Mahfudh Peshu, Judy Faiz, M. Abul Ghose, Aniruddha Hossain, M. Amir Samad, Rasheda Rahman, M. Ridwanur Valecha, Neena Phyo, Aung Pyae Venkatesan, Meera Mishra, Neelima Yi, Poravuth Ashley, Elizabeth A. Dhorda, Mehul Fairhurst, Rick M. Amaratunga, Chanaki Lim, Parath Suon, Seila Sreng, Sokunthea Anderson, Jennifer M. Mao, Sivanna Sam, Baramey Sopha, Chantha Chuor, Char Meng Nguon, Chea Sovannaroth, Siv Pukrittayakamee, Sasithon Jittamala, Podjanee Chotivanich, Kesinee Chutasmit, Kitipumi Suchatsoonthorn, Chaiyaporn Runcharoen, Ratchadaporn Hien, Tran Tinh Thuy-Nhien, Nguyen Thanh Thanh, Ngo Viet Phu, Nguyen Hoan Htut, Ye Han, Kay-Thwe Aye, Kyin Hla Mokuolu, Olugbenga A. Olaosebikan, Rasaq R. Folaranmi, Olaleke O. Mayxay, Mayfong Khanthavong, Maniphone Hongvanthong, Bouasy Newton, Paul N. Onyamboko, Marie A. Fanello, Caterina I. Tshefu, Antoinette K. Nosten, Francois Hasan, M. Mahtabuddin Islam, Akhterul Miotto, Olivo Amato, Roberto MacInnis, Bronwyn Stalker, Jim Kwiatkowski, Dominic P. Bozdech, Zbynek Jeeyapant, Atthanee Cheah, Phaik Yeong Sakulthaew, Tharisara Chalk, Jeremy Intharabut, Benjamas Silamut, Kamolrat Lee, Sue J. Vihokhern, Benchawan Kunasol, Chanon Imwong, Mallika Tarning, Joel Taylor, Walter J. Yeung, Shunmay Woodrow, Charles J. Flegg, Jennifer A. Das, Debashish Smith, Jeffery Plowe, Christopher V. Stepniewska, Kasia Guerin, Philippe J. Dondorp, Arjen M. Day, Nicholas P. White, Nicholas J. Spread of artemisinin resistance in plasmodium falciparum malaria |
| title | Spread of artemisinin resistance in plasmodium falciparum malaria |
| title_full | Spread of artemisinin resistance in plasmodium falciparum malaria |
| title_fullStr | Spread of artemisinin resistance in plasmodium falciparum malaria |
| title_full_unstemmed | Spread of artemisinin resistance in plasmodium falciparum malaria |
| title_short | Spread of artemisinin resistance in plasmodium falciparum malaria |
| title_sort | spread of artemisinin resistance in plasmodium falciparum malaria |
| topic | DRNTU::Science::Biological sciences::Microbiology |
| url | https://hdl.handle.net/10356/106044 http://hdl.handle.net/10220/26243 |
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