Structural characterization of vaccinia-related kinase 1 (VRK1), a histone mitotic kinase
The human vaccinia-related kinase 1 (VRK1), is a mitotic kinase, involved in cell division regulation and carcinogenesis. VRK1 phosphorylates the histone H3 at Thr3 and Ser10, which is a critical event for initiating chromosome condensation during mitosis. The deregulation of VRK1 can affect chromat...
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| Format: | Thesis |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/10356/106061 http://hdl.handle.net/10220/47890 |