Photoactivatable organic semiconducting pro-nanoenzymes
Therapeutic enzymes hold great promise for cancer therapy; however, in vivo remote control of enzymatic activity to improve their therapeutic specificity remains challenging. This study reports the development of an organic semiconducting pro-nanoenzyme (OSPE) with a photoactivatable feature for met...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2019
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| Online Access: | https://hdl.handle.net/10356/106246 http://hdl.handle.net/10220/48098 |
| _version_ | 1826125790058643456 |
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| author | Li, Jingchao Huang, Jiaguo Lyu, Yan Huang, Jingsheng Jiang, Yuyan Xie, Chen Pu, Kanyi |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Li, Jingchao Huang, Jiaguo Lyu, Yan Huang, Jingsheng Jiang, Yuyan Xie, Chen Pu, Kanyi |
| author_sort | Li, Jingchao |
| collection | NTU |
| description | Therapeutic enzymes hold great promise for cancer therapy; however, in vivo remote control of enzymatic activity to improve their therapeutic specificity remains challenging. This study reports the development of an organic semiconducting pro-nanoenzyme (OSPE) with a photoactivatable feature for metastasis-inhibited cancer therapy. Upon near-infrared (NIR) light irradiation, this pro-nanoenzyme not only generates cytotoxic singlet oxygen (1O2) for photodynamic therapy (PDT), but also triggers a spontaneous cascade reaction to induce the degradation of ribonucleic acid (RNA) specifically in tumor microenvironment. More importantly, OSPE-mediated RNA degradation is found to downregulate the expression of metastasis-related proteins, contributing to the inhibition of metastasis after treatment. Such a photoactivated and cancer-specific synergistic therapeutic action of OSPE enables complete inhibition of tumor growth and lung metastasis in mouse xenograft model, which is not possible for the counterpart PDT nanoagent. Thus, our study proposes a phototherapeutic-proenzyme approach toward complete-remission cancer therapy. |
| first_indexed | 2024-10-01T06:42:07Z |
| format | Journal Article |
| id | ntu-10356/106246 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:42:07Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/1062462023-12-29T06:51:05Z Photoactivatable organic semiconducting pro-nanoenzymes Li, Jingchao Huang, Jiaguo Lyu, Yan Huang, Jingsheng Jiang, Yuyan Xie, Chen Pu, Kanyi School of Chemical and Biomedical Engineering Pro-enzymes Organic Nanoparticles DRNTU::Engineering::Chemical engineering Therapeutic enzymes hold great promise for cancer therapy; however, in vivo remote control of enzymatic activity to improve their therapeutic specificity remains challenging. This study reports the development of an organic semiconducting pro-nanoenzyme (OSPE) with a photoactivatable feature for metastasis-inhibited cancer therapy. Upon near-infrared (NIR) light irradiation, this pro-nanoenzyme not only generates cytotoxic singlet oxygen (1O2) for photodynamic therapy (PDT), but also triggers a spontaneous cascade reaction to induce the degradation of ribonucleic acid (RNA) specifically in tumor microenvironment. More importantly, OSPE-mediated RNA degradation is found to downregulate the expression of metastasis-related proteins, contributing to the inhibition of metastasis after treatment. Such a photoactivated and cancer-specific synergistic therapeutic action of OSPE enables complete inhibition of tumor growth and lung metastasis in mouse xenograft model, which is not possible for the counterpart PDT nanoagent. Thus, our study proposes a phototherapeutic-proenzyme approach toward complete-remission cancer therapy. MOE (Min. of Education, S’pore) Accepted version 2019-05-06T01:11:03Z 2019-12-06T22:07:20Z 2019-05-06T01:11:03Z 2019-12-06T22:07:20Z 2019 2019 Journal Article Li, J., Huang, J., Lyu, Y., Huang, J., Jiang, Y., Xie, C., & Pu, K. (2019). Photoactivatable organic semiconducting pro-nanoenzymes. Journal of the American Chemical Society, 141(9), 4073-4079. doi:10.1021/jacs.8b13507 0002-7863 https://hdl.handle.net/10356/106246 http://hdl.handle.net/10220/48098 10.1021/jacs.8b13507 213476 en Journal of the American Chemical Society This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/jacs.8b13507 9 p. application/pdf |
| spellingShingle | Pro-enzymes Organic Nanoparticles DRNTU::Engineering::Chemical engineering Li, Jingchao Huang, Jiaguo Lyu, Yan Huang, Jingsheng Jiang, Yuyan Xie, Chen Pu, Kanyi Photoactivatable organic semiconducting pro-nanoenzymes |
| title | Photoactivatable organic semiconducting pro-nanoenzymes |
| title_full | Photoactivatable organic semiconducting pro-nanoenzymes |
| title_fullStr | Photoactivatable organic semiconducting pro-nanoenzymes |
| title_full_unstemmed | Photoactivatable organic semiconducting pro-nanoenzymes |
| title_short | Photoactivatable organic semiconducting pro-nanoenzymes |
| title_sort | photoactivatable organic semiconducting pro nanoenzymes |
| topic | Pro-enzymes Organic Nanoparticles DRNTU::Engineering::Chemical engineering |
| url | https://hdl.handle.net/10356/106246 http://hdl.handle.net/10220/48098 |
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