Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites
Heterochromatin-dependent gene silencing is central to the adaptation and survival of Plasmodium falciparum malaria parasites, allowing clonally variant gene expression during blood infection in humans. By assessing genome-wide heterochromatin protein 1 (HP1) occupancy, we present a comprehensive an...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/10356/106386 http://hdl.handle.net/10220/49617 |
| _version_ | 1826117108524646400 |
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| author | Fraschka, Sabine A. Filarsky, Michael Hoo, Regina Niederwieser, Igor Yam, Xue Yan Mohring, Franziska Huang, Ximei Christensen, Peter R. Nosten, Francois Bozdech, Zbynek Russell, Bruce Moon, Robert W. Marti, Matthias Bártfai, Richárd Voss, Till S. Brancucci, Nicolas M. B. Mushunje, Annals Tatenda Preiser, Peter Rainer |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Fraschka, Sabine A. Filarsky, Michael Hoo, Regina Niederwieser, Igor Yam, Xue Yan Mohring, Franziska Huang, Ximei Christensen, Peter R. Nosten, Francois Bozdech, Zbynek Russell, Bruce Moon, Robert W. Marti, Matthias Bártfai, Richárd Voss, Till S. Brancucci, Nicolas M. B. Mushunje, Annals Tatenda Preiser, Peter Rainer |
| author_sort | Fraschka, Sabine A. |
| collection | NTU |
| description | Heterochromatin-dependent gene silencing is central to the adaptation and survival of Plasmodium falciparum malaria parasites, allowing clonally variant gene expression during blood infection in humans. By assessing genome-wide heterochromatin protein 1 (HP1) occupancy, we present a comprehensive analysis of heterochromatin landscapes across different Plasmodium species, strains, and life cycle stages. Common targets of epigenetic silencing include fast-evolving multi-gene families encoding surface antigens and a small set of conserved HP1-associated genes with regulatory potential. Many P. falciparum heterochromatic genes are marked in a strain-specific manner, increasing the parasite's adaptive capacity. Whereas heterochromatin is strictly maintained during mitotic proliferation of asexual blood stage parasites, substantial heterochromatin reorganization occurs in differentiating gametocytes and appears crucial for the activation of key gametocyte-specific genes and adaptation of erythrocyte remodeling machinery. Collectively, these findings provide a catalog of heterochromatic genes and reveal conserved and specialized features of epigenetic control across the genus Plasmodium. |
| first_indexed | 2024-10-01T04:22:20Z |
| format | Journal Article |
| id | ntu-10356/106386 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:22:20Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/1063862023-02-28T17:07:19Z Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites Fraschka, Sabine A. Filarsky, Michael Hoo, Regina Niederwieser, Igor Yam, Xue Yan Mohring, Franziska Huang, Ximei Christensen, Peter R. Nosten, Francois Bozdech, Zbynek Russell, Bruce Moon, Robert W. Marti, Matthias Bártfai, Richárd Voss, Till S. Brancucci, Nicolas M. B. Mushunje, Annals Tatenda Preiser, Peter Rainer School of Biological Sciences Plasmodium Malaria Science::Biological sciences Heterochromatin-dependent gene silencing is central to the adaptation and survival of Plasmodium falciparum malaria parasites, allowing clonally variant gene expression during blood infection in humans. By assessing genome-wide heterochromatin protein 1 (HP1) occupancy, we present a comprehensive analysis of heterochromatin landscapes across different Plasmodium species, strains, and life cycle stages. Common targets of epigenetic silencing include fast-evolving multi-gene families encoding surface antigens and a small set of conserved HP1-associated genes with regulatory potential. Many P. falciparum heterochromatic genes are marked in a strain-specific manner, increasing the parasite's adaptive capacity. Whereas heterochromatin is strictly maintained during mitotic proliferation of asexual blood stage parasites, substantial heterochromatin reorganization occurs in differentiating gametocytes and appears crucial for the activation of key gametocyte-specific genes and adaptation of erythrocyte remodeling machinery. Collectively, these findings provide a catalog of heterochromatic genes and reveal conserved and specialized features of epigenetic control across the genus Plasmodium. ASTAR (Agency for Sci., Tech. and Research, S’pore) MOE (Min. of Education, S’pore) NMRC (Natl Medical Research Council, S’pore) MOH (Min. of Health, S’pore) Published version 2019-08-14T02:20:14Z 2019-12-06T22:10:26Z 2019-08-14T02:20:14Z 2019-12-06T22:10:26Z 2018 Journal Article Fraschka, S. A., Filarsky, M., Hoo, R., Niederwieser, I., Yam, X. Y., Brancucci, N. M., . . . Voss, T. S. (2018). Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites. Cell Host and Microbe, 23(3), 407-420. doi:10.1016/j.chom.2018.01.008 1931-3128 https://hdl.handle.net/10356/106386 http://hdl.handle.net/10220/49617 10.1016/j.chom.2018.01.008 en Cell Host and Microbe © 2018 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). 22 p. application/pdf |
| spellingShingle | Plasmodium Malaria Science::Biological sciences Fraschka, Sabine A. Filarsky, Michael Hoo, Regina Niederwieser, Igor Yam, Xue Yan Mohring, Franziska Huang, Ximei Christensen, Peter R. Nosten, Francois Bozdech, Zbynek Russell, Bruce Moon, Robert W. Marti, Matthias Bártfai, Richárd Voss, Till S. Brancucci, Nicolas M. B. Mushunje, Annals Tatenda Preiser, Peter Rainer Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites |
| title | Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites |
| title_full | Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites |
| title_fullStr | Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites |
| title_full_unstemmed | Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites |
| title_short | Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites |
| title_sort | comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites |
| topic | Plasmodium Malaria Science::Biological sciences |
| url | https://hdl.handle.net/10356/106386 http://hdl.handle.net/10220/49617 |
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