Biomedical applications for gas-stabilizing solid cavitation agents
For over a decade, advancements in ultrasound-enhanced drug delivery strategies have demonstrated remarkable success in providing targeted drug delivery for a broad range of diseases. In order to achieve enhanced drug delivery, these strategies harness the mechanical effects from bubble oscillations...
| Autori principali: | , , |
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| Natura: | Journal Article |
| Lingua: | English |
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2019
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| Accesso online: | https://hdl.handle.net/10356/106505 http://hdl.handle.net/10220/49596 |
| _version_ | 1826128584804139008 |
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| author | Thomas, Reju George Jonnalagadda, Umesh Sai Kwan, James Jing |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Thomas, Reju George Jonnalagadda, Umesh Sai Kwan, James Jing |
| author_sort | Thomas, Reju George |
| collection | NTU |
| description | For over a decade, advancements in ultrasound-enhanced drug delivery strategies have demonstrated remarkable success in providing targeted drug delivery for a broad range of diseases. In order to achieve enhanced drug delivery, these strategies harness the mechanical effects from bubble oscillations (i.e., cavitation) of a variety of exogenous cavitation agents. Recently, solid cavitation agents have emerged due to their capacity for drug-loading and sustained cavitation duration. Unlike other cavitation agents, solid cavitation agents stabilize gaseous bubbles on hydrophobic surface cavities. Thus, the design of these particles is crucial. In this Review, we provide an overview of the different designs for solid cavitation agents such as nanocups, nanocones, and porous structures, as well as the current status of their development. Considering the numerous advantages of solid cavitation agents, we anticipate further innovations for this new type of cavitation agent across a broad range of biomedical applications. |
| first_indexed | 2024-10-01T07:27:19Z |
| format | Journal Article |
| id | ntu-10356/106505 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:27:19Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/1065052023-12-29T06:52:16Z Biomedical applications for gas-stabilizing solid cavitation agents Thomas, Reju George Jonnalagadda, Umesh Sai Kwan, James Jing School of Chemical and Biomedical Engineering Therapeutic Ultrasound Cavitation Engineering::Chemical engineering For over a decade, advancements in ultrasound-enhanced drug delivery strategies have demonstrated remarkable success in providing targeted drug delivery for a broad range of diseases. In order to achieve enhanced drug delivery, these strategies harness the mechanical effects from bubble oscillations (i.e., cavitation) of a variety of exogenous cavitation agents. Recently, solid cavitation agents have emerged due to their capacity for drug-loading and sustained cavitation duration. Unlike other cavitation agents, solid cavitation agents stabilize gaseous bubbles on hydrophobic surface cavities. Thus, the design of these particles is crucial. In this Review, we provide an overview of the different designs for solid cavitation agents such as nanocups, nanocones, and porous structures, as well as the current status of their development. Considering the numerous advantages of solid cavitation agents, we anticipate further innovations for this new type of cavitation agent across a broad range of biomedical applications. NMRC (Natl Medical Research Council, S’pore) Accepted version 2019-08-13T03:08:12Z 2019-12-06T22:13:10Z 2019-08-13T03:08:12Z 2019-12-06T22:13:10Z 2019 2019 Journal Article Thomas, R. G., Jonnalagadda, U. S., & Kwan, J. J. (2019). Biomedical applications for gas-stabilizing solid cavitation agents. Langmuir, 35(31), 10106-10115. doi:10.1021/acs.langmuir.9b00795 0743-7463 https://hdl.handle.net/10356/106505 http://hdl.handle.net/10220/49596 10.1021/acs.langmuir.9b00795 213599 en Langmuir This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.langmuir.9b00795 43 p. application/pdf |
| spellingShingle | Therapeutic Ultrasound Cavitation Engineering::Chemical engineering Thomas, Reju George Jonnalagadda, Umesh Sai Kwan, James Jing Biomedical applications for gas-stabilizing solid cavitation agents |
| title | Biomedical applications for gas-stabilizing solid cavitation agents |
| title_full | Biomedical applications for gas-stabilizing solid cavitation agents |
| title_fullStr | Biomedical applications for gas-stabilizing solid cavitation agents |
| title_full_unstemmed | Biomedical applications for gas-stabilizing solid cavitation agents |
| title_short | Biomedical applications for gas-stabilizing solid cavitation agents |
| title_sort | biomedical applications for gas stabilizing solid cavitation agents |
| topic | Therapeutic Ultrasound Cavitation Engineering::Chemical engineering |
| url | https://hdl.handle.net/10356/106505 http://hdl.handle.net/10220/49596 |
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