Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency
Gelatin methacryloyl (GelMA) is a versatile material for a wide range of bioapplications. There is an intense interest in developing effective chemical strategies to prepare GelMA with a high degree of batch-to-batch consistency and controllability in terms of methacryloyl functionalization and phys...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2019
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| Online Access: | https://hdl.handle.net/10356/106551 http://hdl.handle.net/10220/48948 |
| _version_ | 1826113487447785472 |
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| author | Zhu, Mengxiang Wang, Yingying Ferracci, Gaia Zheng, Jing Cho, Nam-Joon Lee, Bae Hoon |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Zhu, Mengxiang Wang, Yingying Ferracci, Gaia Zheng, Jing Cho, Nam-Joon Lee, Bae Hoon |
| author_sort | Zhu, Mengxiang |
| collection | NTU |
| description | Gelatin methacryloyl (GelMA) is a versatile material for a wide range of bioapplications. There is an intense interest in developing effective chemical strategies to prepare GelMA with a high degree of batch-to-batch consistency and controllability in terms of methacryloyl functionalization and physiochemical properties. Herein, we systematically investigated the batch-to-batch reproducibility and controllability of producing GelMA (target highly and lowly substituted versions) via a one-pot strategy. To assess the GelMA product, several parameters were evaluated, including the degree of methacryloylation, secondary structure, and enzymatic degradation, along with the mechanical properties and cell viability of GelMA hydrogels. The results showed that two types of target GelMA with five batches exhibited a high degree of controllability and reproducibility in compositional, structural, and functional properties owing to the highly controllable one-pot strategy. |
| first_indexed | 2024-10-01T03:24:03Z |
| format | Journal Article |
| id | ntu-10356/106551 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:24:03Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/1065512023-07-14T15:49:10Z Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency Zhu, Mengxiang Wang, Yingying Ferracci, Gaia Zheng, Jing Cho, Nam-Joon Lee, Bae Hoon School of Materials Science & Engineering Biomaterials Biomaterials-proteins DRNTU::Engineering::Materials Gelatin methacryloyl (GelMA) is a versatile material for a wide range of bioapplications. There is an intense interest in developing effective chemical strategies to prepare GelMA with a high degree of batch-to-batch consistency and controllability in terms of methacryloyl functionalization and physiochemical properties. Herein, we systematically investigated the batch-to-batch reproducibility and controllability of producing GelMA (target highly and lowly substituted versions) via a one-pot strategy. To assess the GelMA product, several parameters were evaluated, including the degree of methacryloylation, secondary structure, and enzymatic degradation, along with the mechanical properties and cell viability of GelMA hydrogels. The results showed that two types of target GelMA with five batches exhibited a high degree of controllability and reproducibility in compositional, structural, and functional properties owing to the highly controllable one-pot strategy. Published version 2019-06-26T04:33:16Z 2019-12-06T22:13:57Z 2019-06-26T04:33:16Z 2019-12-06T22:13:57Z 2019 Journal Article Zhu, M., Wang, Y., Ferracci, G., Zheng, J., Cho, N.-J., & Lee, B. H. (2019). Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency. Scientific Reports, 9(1), 6863-. doi:10.1038/s41598-019-42186-x https://hdl.handle.net/10356/106551 http://hdl.handle.net/10220/48948 10.1038/s41598-019-42186-x en Scientific Reports © 2019 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. 13 p. application/pdf |
| spellingShingle | Biomaterials Biomaterials-proteins DRNTU::Engineering::Materials Zhu, Mengxiang Wang, Yingying Ferracci, Gaia Zheng, Jing Cho, Nam-Joon Lee, Bae Hoon Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency |
| title | Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency |
| title_full | Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency |
| title_fullStr | Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency |
| title_full_unstemmed | Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency |
| title_short | Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency |
| title_sort | gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch to batch consistency |
| topic | Biomaterials Biomaterials-proteins DRNTU::Engineering::Materials |
| url | https://hdl.handle.net/10356/106551 http://hdl.handle.net/10220/48948 |
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