Breathable medicine : pulmonary mode of drug delivery

Pharmaceutically active compounds require different modes of drug delivery systems to accomplish therapeutic activity without loss of its activity and lead to exhibit no adverse effects. Originating from ancient days, pulmonary mode of drug delivery is gaining much importance compared to other modes...

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Main Authors: Gandhimathi, Chinnasamy, Venugopal, Jayarama Reddy, Sundarrajan, Subramanian, Sridhar, Radhakrishnan, Tay, Samuel Sam Wah, Ramakrishna, Seeram, Kumar, Srinivasan Dinesh
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2015
Subjects:
Online Access:https://hdl.handle.net/10356/106619
http://hdl.handle.net/10220/25006
http://dx.doi.org/10.1166/jnn.2015.10341
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author Gandhimathi, Chinnasamy
Venugopal, Jayarama Reddy
Sundarrajan, Subramanian
Sridhar, Radhakrishnan
Tay, Samuel Sam Wah
Ramakrishna, Seeram
Kumar, Srinivasan Dinesh
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Gandhimathi, Chinnasamy
Venugopal, Jayarama Reddy
Sundarrajan, Subramanian
Sridhar, Radhakrishnan
Tay, Samuel Sam Wah
Ramakrishna, Seeram
Kumar, Srinivasan Dinesh
author_sort Gandhimathi, Chinnasamy
collection NTU
description Pharmaceutically active compounds require different modes of drug delivery systems to accomplish therapeutic activity without loss of its activity and lead to exhibit no adverse effects. Originating from ancient days, pulmonary mode of drug delivery is gaining much importance compared to other modes of drug delivery systems with respect to specific diseases. Pulmonary drug delivery is a non-invasive route for local and systemic therapies together with more patient convenience, compliance and is a needleless system. In this review, we addressed the vaccine delivery via nonor minimally invasive routes. Polymeric nanoparticles are preferred for use in the pulmonary delivery devices owing to a prolonged retention in lungs. Small site for absorption, mucociliary clearance, short residence time and low bioavailability are some of the limitations in pulmonary drug delivery have been resolved by generating micro- and nano-sized aerosol particles. We have classified the breathable medicine on the basis of available devices for inhalation and also prominent diseases treated through pulmonary mode of drug delivery. Owing to increasing toxicity of pharmacological drugs, the use of natural medicines has been rapidly gaining importance recently. The review article describes breathability of medicines or the pulmonary mode of drug delivery system and their drug release profile, absorption, distribution and efficacy to cure asthma and diabetes.
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spelling ntu-10356/1066192019-12-06T22:15:00Z Breathable medicine : pulmonary mode of drug delivery Gandhimathi, Chinnasamy Venugopal, Jayarama Reddy Sundarrajan, Subramanian Sridhar, Radhakrishnan Tay, Samuel Sam Wah Ramakrishna, Seeram Kumar, Srinivasan Dinesh Lee Kong Chian School of Medicine (LKCMedicine) DRNTU::Engineering::Nanotechnology Pharmaceutically active compounds require different modes of drug delivery systems to accomplish therapeutic activity without loss of its activity and lead to exhibit no adverse effects. Originating from ancient days, pulmonary mode of drug delivery is gaining much importance compared to other modes of drug delivery systems with respect to specific diseases. Pulmonary drug delivery is a non-invasive route for local and systemic therapies together with more patient convenience, compliance and is a needleless system. In this review, we addressed the vaccine delivery via nonor minimally invasive routes. Polymeric nanoparticles are preferred for use in the pulmonary delivery devices owing to a prolonged retention in lungs. Small site for absorption, mucociliary clearance, short residence time and low bioavailability are some of the limitations in pulmonary drug delivery have been resolved by generating micro- and nano-sized aerosol particles. We have classified the breathable medicine on the basis of available devices for inhalation and also prominent diseases treated through pulmonary mode of drug delivery. Owing to increasing toxicity of pharmacological drugs, the use of natural medicines has been rapidly gaining importance recently. The review article describes breathability of medicines or the pulmonary mode of drug delivery system and their drug release profile, absorption, distribution and efficacy to cure asthma and diabetes. 2015-02-02T06:28:17Z 2019-12-06T22:15:00Z 2015-02-02T06:28:17Z 2019-12-06T22:15:00Z 2015 2015 Journal Article Gandhimathi, C., Venugopal, J. R., Sundarrajan, S., Sridhar, R., Tay, S. S. W., Ramakrishna, S., et al. (2015). Breathable medicine : pulmonary mode of drug delivery. Journal of nanoscience and nanotechnology, 15(4), 2591-2604. 1533-4880 https://hdl.handle.net/10356/106619 http://hdl.handle.net/10220/25006 http://dx.doi.org/10.1166/jnn.2015.10341 en Journal of nanoscience and nanotechnology © 2015 American Scientific Publishers
spellingShingle DRNTU::Engineering::Nanotechnology
Gandhimathi, Chinnasamy
Venugopal, Jayarama Reddy
Sundarrajan, Subramanian
Sridhar, Radhakrishnan
Tay, Samuel Sam Wah
Ramakrishna, Seeram
Kumar, Srinivasan Dinesh
Breathable medicine : pulmonary mode of drug delivery
title Breathable medicine : pulmonary mode of drug delivery
title_full Breathable medicine : pulmonary mode of drug delivery
title_fullStr Breathable medicine : pulmonary mode of drug delivery
title_full_unstemmed Breathable medicine : pulmonary mode of drug delivery
title_short Breathable medicine : pulmonary mode of drug delivery
title_sort breathable medicine pulmonary mode of drug delivery
topic DRNTU::Engineering::Nanotechnology
url https://hdl.handle.net/10356/106619
http://hdl.handle.net/10220/25006
http://dx.doi.org/10.1166/jnn.2015.10341
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