RIG-I activation by a designer short RNA ligand protects human immune cells against dengue virus infection without causing cytotoxicity

RIG-I activation by a designer short RNA ligand protects human immune cells against dengue virus infection without causing cytotoxicity

Virus-derived double-stranded RNA (dsRNA) molecules containing a triphosphate group at the 5′ end are natural ligands of retinoic acid-inducible gene I (RIG-I). The cellular pathways and proteins induced by RIG-I are an essential part of the innate immune response against viral infections. Starting...

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Bibliographic Details
Main Authors: Fink, Katja, Ho, Victor, Yong, Hui Yee, Chevrier, Marion, Narang, Vipin, Lum, Josephine, Toh, Ying-Xiu, Lee, Bernett, Chen, Jinmiao, Tan, Ern Yu, Luo, Dahai
Other Authors: Williams, Bryan RG.
Format: Journal Article
Language:English
Published: 2019
Subjects:
Dengue
RIG-I
Science::Biological sciences
Online Access:https://hdl.handle.net/10356/106854
http://hdl.handle.net/10220/49675

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