Hollow agarose microneedle with silver coating for intradermal surface-enhanced Raman measurements : a skin-mimicking phantom study
Human intradermal components contain important clinical information beneficial to the field of immunology and disease diagnosis. Although microneedles have shown great potential to act as probes to break the human skin barrier for the minimally invasive measurement of intradermal components, metal m...
| Egile Nagusiak: | , |
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| Beste egile batzuk: | |
| Formatua: | Journal Article |
| Hizkuntza: | English |
| Argitaratua: |
2015
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| Gaiak: | |
| Sarrera elektronikoa: | https://hdl.handle.net/10356/106904 http://hdl.handle.net/10220/25242 |
| _version_ | 1826112388571594752 |
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| author | Yuen, Clement Liu, Quan |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Yuen, Clement Liu, Quan |
| author_sort | Yuen, Clement |
| collection | NTU |
| description | Human intradermal components contain important clinical information beneficial to the field of immunology and disease diagnosis. Although microneedles have shown great potential to act as probes to break the human skin barrier for the minimally invasive measurement of intradermal components, metal microneedles that include stainless steel could cause the following problems: (1) sharp waste production, and (2) contamination due to reuse of microneedles especially in developing regions. In this study, we fabricate agarose microneedles coated with a layer of silver (Ag) and demonstrate their use as a probe for the realization of intradermal surface-enhanced Raman scattering measurements in a set of skin-mimicking phantoms. The Ag-coated agarose microneedle quantifies a range of glucose concentrations from 5 to 150 mM inside the skin phantoms with a root-mean-square error of 5.1 mM within 10 s. The needle is found enlarged by 53.9% after another 6 min inside the phantom. The shape-changing capability of this agarose microneedle ensures that the reuse of these microneedles is impossible, thus avoiding sharp waste production and preventing needle contamination, which shows the great potential for safe and effective needle-based measurements. |
| first_indexed | 2024-10-01T03:06:11Z |
| format | Journal Article |
| id | ntu-10356/106904 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:06:11Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | ntu-10356/1069042023-12-29T06:46:09Z Hollow agarose microneedle with silver coating for intradermal surface-enhanced Raman measurements : a skin-mimicking phantom study Yuen, Clement Liu, Quan School of Chemical and Biomedical Engineering DRNTU::Science::Medicine::Biomedical engineering Human intradermal components contain important clinical information beneficial to the field of immunology and disease diagnosis. Although microneedles have shown great potential to act as probes to break the human skin barrier for the minimally invasive measurement of intradermal components, metal microneedles that include stainless steel could cause the following problems: (1) sharp waste production, and (2) contamination due to reuse of microneedles especially in developing regions. In this study, we fabricate agarose microneedles coated with a layer of silver (Ag) and demonstrate their use as a probe for the realization of intradermal surface-enhanced Raman scattering measurements in a set of skin-mimicking phantoms. The Ag-coated agarose microneedle quantifies a range of glucose concentrations from 5 to 150 mM inside the skin phantoms with a root-mean-square error of 5.1 mM within 10 s. The needle is found enlarged by 53.9% after another 6 min inside the phantom. The shape-changing capability of this agarose microneedle ensures that the reuse of these microneedles is impossible, thus avoiding sharp waste production and preventing needle contamination, which shows the great potential for safe and effective needle-based measurements. Published version 2015-03-12T03:02:24Z 2019-12-06T22:20:40Z 2015-03-12T03:02:24Z 2019-12-06T22:20:40Z 2015 2015 Journal Article Yuen, C., & Liu, Q. (2015). Hollow agarose microneedle with silver coating for intradermal surface-enhanced Raman measurements : a skin-mimicking phantom study. Journal of biomedical optics, 20(6), 061102-. 1083-3668 https://hdl.handle.net/10356/106904 http://hdl.handle.net/10220/25242 10.1117/1.JBO.20.6.061102 en Journal of biomedical optics © 2015 Society of Photo-Optical Instrumentation Engineers. This paper was published in Journal of Biomedical Optics and is made available as an electronic reprint (preprint) with permission of Society of Photo-Optical Instrumentation Engineers. The paper can be found at the following official DOI: [http://dx.doi.org/10.1117/1.JBO.20.6.061102]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 8 p. application/pdf |
| spellingShingle | DRNTU::Science::Medicine::Biomedical engineering Yuen, Clement Liu, Quan Hollow agarose microneedle with silver coating for intradermal surface-enhanced Raman measurements : a skin-mimicking phantom study |
| title | Hollow agarose microneedle with silver coating for intradermal surface-enhanced Raman measurements : a skin-mimicking phantom study |
| title_full | Hollow agarose microneedle with silver coating for intradermal surface-enhanced Raman measurements : a skin-mimicking phantom study |
| title_fullStr | Hollow agarose microneedle with silver coating for intradermal surface-enhanced Raman measurements : a skin-mimicking phantom study |
| title_full_unstemmed | Hollow agarose microneedle with silver coating for intradermal surface-enhanced Raman measurements : a skin-mimicking phantom study |
| title_short | Hollow agarose microneedle with silver coating for intradermal surface-enhanced Raman measurements : a skin-mimicking phantom study |
| title_sort | hollow agarose microneedle with silver coating for intradermal surface enhanced raman measurements a skin mimicking phantom study |
| topic | DRNTU::Science::Medicine::Biomedical engineering |
| url | https://hdl.handle.net/10356/106904 http://hdl.handle.net/10220/25242 |
| work_keys_str_mv | AT yuenclement hollowagarosemicroneedlewithsilvercoatingforintradermalsurfaceenhancedramanmeasurementsaskinmimickingphantomstudy AT liuquan hollowagarosemicroneedlewithsilvercoatingforintradermalsurfaceenhancedramanmeasurementsaskinmimickingphantomstudy |