Tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release
Modulating the drug release from polyester matrices independently of material properties would be beneficial to those designing biodegradable medical implants, such as drug delivery devices, stents and screws. However, the most common approaches use additives that often drastically alter the desired...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/107001 http://hdl.handle.net/10220/17865 |
| _version_ | 1811695947330093056 |
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| author | Steele, Terry W. J. Huang, Charlotte Liwen Kumar, Saranya Iskandar, Aneesa Baoxin, Aw Boey, Freddy Yin Chiang Loo, Say Chye Joachim Venkatraman, Subbu S. |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Steele, Terry W. J. Huang, Charlotte Liwen Kumar, Saranya Iskandar, Aneesa Baoxin, Aw Boey, Freddy Yin Chiang Loo, Say Chye Joachim Venkatraman, Subbu S. |
| author_sort | Steele, Terry W. J. |
| collection | NTU |
| description | Modulating the drug release from polyester matrices independently of material properties would be beneficial to those designing biodegradable medical implants, such as drug delivery devices, stents and screws. However, the most common approaches use additives that often drastically alter the desired material properties. Recently, we have developed tools that allow gradient film formulations and high-throughput drug quantitation for the determination of parameter-specific correlations. We propose that modulated drug release can be obtained via additive-free mechanisms in polyesters by simply controlling polymer erosion through acidic terminal functional groups. Our results showed that drug release in poly(lactic-co-glycolic acid) (PLGA) formulations could be tuned to produce large ranges in drug release with relatively small changes in terminal acidic functional groups. For example, PLGA 53/47 thin films could be tuned to have 10–60% drug release at 14 days or 10–90% drug release at 20 days, depending on the PLGA/PLGA blend formulation and concentration of acidic terminal functional groups. A linear R-square correlation of up to 0.9 was observed for the acidic groups and percent drug release. Below a threshold of 1 part per thousand acidic groups, there was no increase in drug release, which has implications for polymer processing and film integrity. |
| first_indexed | 2024-10-01T07:31:34Z |
| format | Journal Article |
| id | ntu-10356/107001 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:31:34Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/1070012023-07-14T15:54:23Z Tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release Steele, Terry W. J. Huang, Charlotte Liwen Kumar, Saranya Iskandar, Aneesa Baoxin, Aw Boey, Freddy Yin Chiang Loo, Say Chye Joachim Venkatraman, Subbu S. School of Materials Science & Engineering Modulating the drug release from polyester matrices independently of material properties would be beneficial to those designing biodegradable medical implants, such as drug delivery devices, stents and screws. However, the most common approaches use additives that often drastically alter the desired material properties. Recently, we have developed tools that allow gradient film formulations and high-throughput drug quantitation for the determination of parameter-specific correlations. We propose that modulated drug release can be obtained via additive-free mechanisms in polyesters by simply controlling polymer erosion through acidic terminal functional groups. Our results showed that drug release in poly(lactic-co-glycolic acid) (PLGA) formulations could be tuned to produce large ranges in drug release with relatively small changes in terminal acidic functional groups. For example, PLGA 53/47 thin films could be tuned to have 10–60% drug release at 14 days or 10–90% drug release at 20 days, depending on the PLGA/PLGA blend formulation and concentration of acidic terminal functional groups. A linear R-square correlation of up to 0.9 was observed for the acidic groups and percent drug release. Below a threshold of 1 part per thousand acidic groups, there was no increase in drug release, which has implications for polymer processing and film integrity. Published Version 2013-11-27T05:11:11Z 2019-12-06T22:22:50Z 2013-11-27T05:11:11Z 2019-12-06T22:22:50Z 2013 2013 Journal Article Steele, T. W. J., Huang, C. L., Kumar, S., Iskandar, A., Baoxin, A., Boey, F. Y. C., Loo, S. C. J., & Venkatraman, S. S. (2013). Tuning drug release in polyester thin films: terminal end-groups determine specific rates of additive-free controlled drug release. NPG Asia materials, 5(4), e46-. 1884-4057 https://hdl.handle.net/10356/107001 http://hdl.handle.net/10220/17865 10.1038/am.2013.9 en NPG Asia materials © 2013 Nature Japan K.K. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/. application/pdf |
| spellingShingle | Steele, Terry W. J. Huang, Charlotte Liwen Kumar, Saranya Iskandar, Aneesa Baoxin, Aw Boey, Freddy Yin Chiang Loo, Say Chye Joachim Venkatraman, Subbu S. Tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release |
| title | Tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release |
| title_full | Tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release |
| title_fullStr | Tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release |
| title_full_unstemmed | Tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release |
| title_short | Tuning drug release in polyester thin films : terminal end-groups determine specific rates of additive-free controlled drug release |
| title_sort | tuning drug release in polyester thin films terminal end groups determine specific rates of additive free controlled drug release |
| url | https://hdl.handle.net/10356/107001 http://hdl.handle.net/10220/17865 |
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