Nickel-catalyzed asymmetric transfer hydrogenation of hydrazones and other ketimines

Nickel-catalyzed asymmetric transfer hydrogenation of hydrazones and other ketimines

We report the use of nickel catalysts for the catalytic transfer hydrogenation of hydrazones and other ketimines with formic acid. Strongly donating bisphosphines must be used to support the catalysts. As in enzymatic catalysis, attractive weak interactions may be important for stereochemical contro...

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Bibliographic Details
Main Authors: Xu, Haiyan, Yang, Peng, Chuanprasit, Pratanphorn, Hirao, Hajime, Zhou, Steve Jianrong
Other Authors: School of Physical and Mathematical Sciences
Format: Journal Article
Language:English
Published: 2015
Subjects:
DRNTU::Science::Chemistry::Physical chemistry::Catalysis
Online Access:https://hdl.handle.net/10356/107036
http://hdl.handle.net/10220/25269
http://dx.doi.org/10.1002/anie.201501018
Description
Summary:We report the use of nickel catalysts for the catalytic transfer hydrogenation of hydrazones and other ketimines with formic acid. Strongly donating bisphosphines must be used to support the catalysts. As in enzymatic catalysis, attractive weak interactions may be important for stereochemical control by the nickel/binapine catalyst.

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