Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria
Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic letha...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/107554 http://hdl.handle.net/10220/44801 |
| _version_ | 1811685848143364096 |
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| author | Guan, Xue Li Subramaniam, Suvitha Schmid, Christoph D. Mäser, Pascal |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Guan, Xue Li Subramaniam, Suvitha Schmid, Christoph D. Mäser, Pascal |
| author_sort | Guan, Xue Li |
| collection | NTU |
| description | Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic lethal interaction but are absent in humans. This suggests new options for drug combinations, particularly for inhibitors of targets such as P. falciparum calcineurin, cation ATPase 4, or phosphatidylinositol 4-kinase. |
| first_indexed | 2024-10-01T04:51:02Z |
| format | Journal Article |
| id | ntu-10356/107554 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:51:02Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/1075542020-11-01T05:19:06Z Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria Guan, Xue Li Subramaniam, Suvitha Schmid, Christoph D. Mäser, Pascal Lee Kong Chian School of Medicine (LKCMedicine) Antimalarials Combinatorial Chemotherapy Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic lethal interaction but are absent in humans. This suggests new options for drug combinations, particularly for inhibitors of targets such as P. falciparum calcineurin, cation ATPase 4, or phosphatidylinositol 4-kinase. Published version 2018-05-16T04:19:11Z 2019-12-06T22:33:55Z 2018-05-16T04:19:11Z 2019-12-06T22:33:55Z 2018 Journal Article Subramaniam, S., Schmid, C. D., Guan, X. L., & Mäser, P. (2018). Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria. Antimicrobial Agents and Chemotherapy, 62(4), e01533-17-. 0066-4804 https://hdl.handle.net/10356/107554 http://hdl.handle.net/10220/44801 10.1128/AAC.01533-17 en Antimicrobial Agents and Chemotherapy © 2018 Subramaniam et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. 5 p. application/pdf |
| spellingShingle | Antimalarials Combinatorial Chemotherapy Guan, Xue Li Subramaniam, Suvitha Schmid, Christoph D. Mäser, Pascal Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria |
| title | Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria |
| title_full | Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria |
| title_fullStr | Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria |
| title_full_unstemmed | Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria |
| title_short | Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria |
| title_sort | using yeast synthetic lethality to inform drug combination for malaria |
| topic | Antimalarials Combinatorial Chemotherapy |
| url | https://hdl.handle.net/10356/107554 http://hdl.handle.net/10220/44801 |
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