Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria
Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic letha...
Main Authors: | Guan, Xue Li, Subramaniam, Suvitha, Schmid, Christoph D., Mäser, Pascal |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Journal Article |
Language: | English |
Published: |
2018
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/107554 http://hdl.handle.net/10220/44801 |
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