Scaffold-mediated sequential drug/gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries
Neural tissue regeneration following traumatic injuries is often subpar. As a result, the field of neural tissue engineering has evolved to find therapeutic interventions and has seen promising outcomes. However, robust nerve and myelin regeneration remain elusive. One possible reason may be the fac...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | https://hdl.handle.net/10356/136653 |
| _version_ | 1826114006821109760 |
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| author | Ong, William Pinese, Coline Chew, Sing Yian |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Ong, William Pinese, Coline Chew, Sing Yian |
| author_sort | Ong, William |
| collection | NTU |
| description | Neural tissue regeneration following traumatic injuries is often subpar. As a result, the field of neural tissue engineering has evolved to find therapeutic interventions and has seen promising outcomes. However, robust nerve and myelin regeneration remain elusive. One possible reason may be the fact that tissue regeneration often follows a complex sequence of events in a temporally-controlled manner. Although several other fields of tissue engineering have begun to recognise the importance of delivering two or more biomolecules sequentially for more complete tissue regeneration, such serial delivery of biomolecules in neural tissue engineering remains limited. This review aims to highlight the need for sequential delivery to enhance nerve regeneration and remyelination after traumatic injuries in the central nervous system, using spinal cord injuries as an example. In addition, possible methods to attain temporally-controlled drug/gene delivery are also discussed for effective neural tissue regeneration. |
| first_indexed | 2024-10-01T03:32:09Z |
| format | Journal Article |
| id | ntu-10356/136653 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:32:09Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1366532023-12-29T06:46:40Z Scaffold-mediated sequential drug/gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries Ong, William Pinese, Coline Chew, Sing Yian School of Chemical and Biomedical Engineering Interdisciplinary Graduate School (IGS) Lee Kong Chian School of Medicine (LKCMedicine) Engineering::Chemical engineering Neural Tissue Engineering Sequential Delivery Neural tissue regeneration following traumatic injuries is often subpar. As a result, the field of neural tissue engineering has evolved to find therapeutic interventions and has seen promising outcomes. However, robust nerve and myelin regeneration remain elusive. One possible reason may be the fact that tissue regeneration often follows a complex sequence of events in a temporally-controlled manner. Although several other fields of tissue engineering have begun to recognise the importance of delivering two or more biomolecules sequentially for more complete tissue regeneration, such serial delivery of biomolecules in neural tissue engineering remains limited. This review aims to highlight the need for sequential delivery to enhance nerve regeneration and remyelination after traumatic injuries in the central nervous system, using spinal cord injuries as an example. In addition, possible methods to attain temporally-controlled drug/gene delivery are also discussed for effective neural tissue regeneration. NRF (Natl Research Foundation, S’pore) NMRC (Natl Medical Research Council, S’pore) MOH (Min. of Health, S’pore) Accepted version 2020-01-09T02:44:03Z 2020-01-09T02:44:03Z 2019 Journal Article Ong, W., Pinese, C., & Chew, S. Y. (2019). Scaffold-mediated sequential drug/gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries. Advanced Drug Delivery Reviews, 149-15019-48. doi:10.1016/j.addr.2019.03.004 0169-409X https://hdl.handle.net/10356/136653 10.1016/j.addr.2019.03.004 149-150 19 48 en Advanced Drug Delivery Reviews © 2019 Elsevier. All rights reserved. This paper was published in Advanced Drug Delivery Reviews and is made available with permission of Elsevier. application/pdf |
| spellingShingle | Engineering::Chemical engineering Neural Tissue Engineering Sequential Delivery Ong, William Pinese, Coline Chew, Sing Yian Scaffold-mediated sequential drug/gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries |
| title | Scaffold-mediated sequential drug/gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries |
| title_full | Scaffold-mediated sequential drug/gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries |
| title_fullStr | Scaffold-mediated sequential drug/gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries |
| title_full_unstemmed | Scaffold-mediated sequential drug/gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries |
| title_short | Scaffold-mediated sequential drug/gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries |
| title_sort | scaffold mediated sequential drug gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries |
| topic | Engineering::Chemical engineering Neural Tissue Engineering Sequential Delivery |
| url | https://hdl.handle.net/10356/136653 |
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