Biomolecular interaction and kinematics differences between P25 and E171 TiO2 nanoparticles
Titanium dioxide (TiO2) nanoparticles (NPs) are used abundantly as food additives (E171). For the purpose of risk assessment, it is imperative to understand the behavior of these nanoparticles in a food relevant environment, and their consequent toxicology impacts. However, most of such studies use...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | https://hdl.handle.net/10356/136963 |
| _version_ | 1826117888310771712 |
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| author | Ridhwan Yusoff Kathawala, Mustafa Hussain Nguyen, Luong Thi Hien Setyawati, Magdiel Inggrid Chiew, Paul Wu, Yuansheng Ch'ng, Ai Lee Wang, Zheng Ming Ng, Kee Woei |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Ridhwan Yusoff Kathawala, Mustafa Hussain Nguyen, Luong Thi Hien Setyawati, Magdiel Inggrid Chiew, Paul Wu, Yuansheng Ch'ng, Ai Lee Wang, Zheng Ming Ng, Kee Woei |
| author_sort | Ridhwan Yusoff |
| collection | NTU |
| description | Titanium dioxide (TiO2) nanoparticles (NPs) are used abundantly as food additives (E171). For the purpose of risk assessment, it is imperative to understand the behavior of these nanoparticles in a food relevant environment, and their consequent toxicology impacts. However, most of such studies use model TiO2 NPs (P25) as substitutes for E171. To understand the suitability of this approach, we investigated the functional behavior of E171 and P25 in solutions of bovine serum albumin (BSA) and sucrose as model food ingredients. Our data showed that E171 were better dispersed in BSA than P25. In sucrose, E171 displayed a reduction in agglomerated size while P25 agglomerated extensively. Adsorption studies showed that P25 attracted more pronounced corona formation per unit mass of material compared to E171. In vitro sedimentation, diffusion and dosimetry (ISDD) results demonstrated that the time-weighted dosage of E171 was more than two-folds higher than P25, implying that any test performed using P25 to model E171 would underestimate actual dosage and potential toxicity. Taken collectively, this study demonstrated the specificity of TiO2 nanoparticle interaction with food ingredients, and the importance of using food-grade E171 TiO2 for food-relevant toxicological assessments. |
| first_indexed | 2024-10-01T04:34:44Z |
| format | Journal Article |
| id | ntu-10356/136963 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:34:44Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1369632023-07-14T15:56:53Z Biomolecular interaction and kinematics differences between P25 and E171 TiO2 nanoparticles Ridhwan Yusoff Kathawala, Mustafa Hussain Nguyen, Luong Thi Hien Setyawati, Magdiel Inggrid Chiew, Paul Wu, Yuansheng Ch'ng, Ai Lee Wang, Zheng Ming Ng, Kee Woei School of Materials Science & Engineering Engineering::Materials Nanoparticles Titanium Dioxide Titanium dioxide (TiO2) nanoparticles (NPs) are used abundantly as food additives (E171). For the purpose of risk assessment, it is imperative to understand the behavior of these nanoparticles in a food relevant environment, and their consequent toxicology impacts. However, most of such studies use model TiO2 NPs (P25) as substitutes for E171. To understand the suitability of this approach, we investigated the functional behavior of E171 and P25 in solutions of bovine serum albumin (BSA) and sucrose as model food ingredients. Our data showed that E171 were better dispersed in BSA than P25. In sucrose, E171 displayed a reduction in agglomerated size while P25 agglomerated extensively. Adsorption studies showed that P25 attracted more pronounced corona formation per unit mass of material compared to E171. In vitro sedimentation, diffusion and dosimetry (ISDD) results demonstrated that the time-weighted dosage of E171 was more than two-folds higher than P25, implying that any test performed using P25 to model E171 would underestimate actual dosage and potential toxicity. Taken collectively, this study demonstrated the specificity of TiO2 nanoparticle interaction with food ingredients, and the importance of using food-grade E171 TiO2 for food-relevant toxicological assessments. Accepted version 2020-02-07T05:10:57Z 2020-02-07T05:10:57Z 2018 Journal Article Ridhwan Yusoff., Kathawala, M. H., Nguyen, L. T. H., Setyawati, M. I., Chiew, P., Wu, Y. et al. (2018). Biomolecular interaction and kinematics differences between P25 and E171 TiO2 nanoparticles. Nanoimpact, 12, 51-57. doi:10.1016/j.impact.2018.10.001 2452-0748 https://hdl.handle.net/10356/136963 10.1016/j.impact.2018.10.001 2-s2.0-85055441764 12 51 57 en NanoImpact © 2018 Elsevier B.V. All rights reserved. This paper was published in Nanoimpact and is made available with permission of Elsevier B.V. application/pdf |
| spellingShingle | Engineering::Materials Nanoparticles Titanium Dioxide Ridhwan Yusoff Kathawala, Mustafa Hussain Nguyen, Luong Thi Hien Setyawati, Magdiel Inggrid Chiew, Paul Wu, Yuansheng Ch'ng, Ai Lee Wang, Zheng Ming Ng, Kee Woei Biomolecular interaction and kinematics differences between P25 and E171 TiO2 nanoparticles |
| title | Biomolecular interaction and kinematics differences between P25 and E171 TiO2 nanoparticles |
| title_full | Biomolecular interaction and kinematics differences between P25 and E171 TiO2 nanoparticles |
| title_fullStr | Biomolecular interaction and kinematics differences between P25 and E171 TiO2 nanoparticles |
| title_full_unstemmed | Biomolecular interaction and kinematics differences between P25 and E171 TiO2 nanoparticles |
| title_short | Biomolecular interaction and kinematics differences between P25 and E171 TiO2 nanoparticles |
| title_sort | biomolecular interaction and kinematics differences between p25 and e171 tio2 nanoparticles |
| topic | Engineering::Materials Nanoparticles Titanium Dioxide |
| url | https://hdl.handle.net/10356/136963 |
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