Recent advances in cell membrane-camouflaged nanoparticles for cancer phototherapy
Phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) employs phototherapeutic agents to generate heat or cytotoxic reactive oxygen species (ROS), and has therefore garnered particular interest for cancer therapy. However, the main challenges faced by conventional photothe...
| Main Authors: | , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/137154 |
| _version_ | 1826117888506855424 |
|---|---|
| author | Zhen, Xu Cheng, Penghui Pu, Kanyi |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Zhen, Xu Cheng, Penghui Pu, Kanyi |
| author_sort | Zhen, Xu |
| collection | NTU |
| description | Phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) employs phototherapeutic agents to generate heat or cytotoxic reactive oxygen species (ROS), and has therefore garnered particular interest for cancer therapy. However, the main challenges faced by conventional phototherapeutic agents include easy recognition by the immune system, rapid clearance from blood circulation, and low accumulation in target sites. Cell-membrane coating has emerged as a potential way to overcome these limitations, owing to the abundant proteins on the surface of cell membranes that can be inherited to the cell membrane-camouflaged nanoparticles. This review summarizes the recent advances in the development of biomimetic cell membrane-camouflaged nanoparticles for cancer phototherapy. Different sources of cell membranes can be used to coat nanoparticles uisng different coating approaches. After cell-membrane coating, the photophysical properties of the original phototherapeutic nanoparticles remain nearly unchanged; however, the coated nanoparticles are equipped with additional physiological features including immune escape, in vivo prolonged circulation time, or homologous targeting, depending on the cell sources. Moreover, the coated cell membrane can be ablated from phototherapeutic nanoparticles under laser irradiation, leading to drug release and thus synergetic therapy. By combining other supplementary agents to normalize tumor microenvironment, cell-membrane coating can further enhance the therapeutic efficacy against cancer. |
| first_indexed | 2024-10-01T04:34:44Z |
| format | Journal Article |
| id | ntu-10356/137154 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:34:44Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1371542023-12-29T06:47:58Z Recent advances in cell membrane-camouflaged nanoparticles for cancer phototherapy Zhen, Xu Cheng, Penghui Pu, Kanyi School of Chemical and Biomedical Engineering Engineering::Chemical engineering Biomimetic Nanoparticles Cell Membrane Phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) employs phototherapeutic agents to generate heat or cytotoxic reactive oxygen species (ROS), and has therefore garnered particular interest for cancer therapy. However, the main challenges faced by conventional phototherapeutic agents include easy recognition by the immune system, rapid clearance from blood circulation, and low accumulation in target sites. Cell-membrane coating has emerged as a potential way to overcome these limitations, owing to the abundant proteins on the surface of cell membranes that can be inherited to the cell membrane-camouflaged nanoparticles. This review summarizes the recent advances in the development of biomimetic cell membrane-camouflaged nanoparticles for cancer phototherapy. Different sources of cell membranes can be used to coat nanoparticles uisng different coating approaches. After cell-membrane coating, the photophysical properties of the original phototherapeutic nanoparticles remain nearly unchanged; however, the coated nanoparticles are equipped with additional physiological features including immune escape, in vivo prolonged circulation time, or homologous targeting, depending on the cell sources. Moreover, the coated cell membrane can be ablated from phototherapeutic nanoparticles under laser irradiation, leading to drug release and thus synergetic therapy. By combining other supplementary agents to normalize tumor microenvironment, cell-membrane coating can further enhance the therapeutic efficacy against cancer. MOE (Min. of Education, S’pore) Accepted version 2020-03-04T01:09:59Z 2020-03-04T01:09:59Z 2018 Journal Article Zhen, X., Cheng, P., & Pu, K. (2018). Recent advances in cell membrane-camouflaged nanoparticles for cancer phototherapy. Small, 15(1), 1804105-. doi:10.1002/smll.201804105 1613-6810 https://hdl.handle.net/10356/137154 10.1002/smll.201804105 30457701 2-s2.0-85056774851 1 15 en Small This is the peer reviewed version of the following article: Zhen, X., Cheng, P., & Pu, K. (2018). Recent advances in cell membrane-camouflaged nanoparticles for cancer phototherapy. Small, 15(1), 1804105-., which has been published in final form at [10.1002/smll.201804105]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf |
| spellingShingle | Engineering::Chemical engineering Biomimetic Nanoparticles Cell Membrane Zhen, Xu Cheng, Penghui Pu, Kanyi Recent advances in cell membrane-camouflaged nanoparticles for cancer phototherapy |
| title | Recent advances in cell membrane-camouflaged nanoparticles for cancer phototherapy |
| title_full | Recent advances in cell membrane-camouflaged nanoparticles for cancer phototherapy |
| title_fullStr | Recent advances in cell membrane-camouflaged nanoparticles for cancer phototherapy |
| title_full_unstemmed | Recent advances in cell membrane-camouflaged nanoparticles for cancer phototherapy |
| title_short | Recent advances in cell membrane-camouflaged nanoparticles for cancer phototherapy |
| title_sort | recent advances in cell membrane camouflaged nanoparticles for cancer phototherapy |
| topic | Engineering::Chemical engineering Biomimetic Nanoparticles Cell Membrane |
| url | https://hdl.handle.net/10356/137154 |
| work_keys_str_mv | AT zhenxu recentadvancesincellmembranecamouflagednanoparticlesforcancerphototherapy AT chengpenghui recentadvancesincellmembranecamouflagednanoparticlesforcancerphototherapy AT pukanyi recentadvancesincellmembranecamouflagednanoparticlesforcancerphototherapy |