Molecular fluorescence and photoacoustic imaging in the second near-infrared optical window using organic contrast agents
Noninvasive near-infrared (NIR) light ranging from 650 to 1000 nm (NIR-I) is widely employed in fundamental research and clinical applications; however, a recently discovered second NIR (NIR-II) window from 1000 to 1700 nm exhibits even better deep-tissue imaging capability due to reduced photon sca...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/137172 |
| _version_ | 1826121400466800640 |
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| author | Jiang, Yuyan Pu, Kanyi |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Jiang, Yuyan Pu, Kanyi |
| author_sort | Jiang, Yuyan |
| collection | NTU |
| description | Noninvasive near-infrared (NIR) light ranging from 650 to 1000 nm (NIR-I) is widely employed in fundamental research and clinical applications; however, a recently discovered second NIR (NIR-II) window from 1000 to 1700 nm exhibits even better deep-tissue imaging capability due to reduced photon scattering, minimized tissue autofluorescence, and increased applicable power at longer wavelengths. This review focuses on recent advances of organic contrast agents developed for in vivo fluorescence and photoacoustic imaging in the NIR-II optical window. The superiority of the NIR-II over the NIR-I window for molecular imaging is first discussed in detail, followed by discussion of fluorescence and photoacoustic imaging of cancer, vasculature, and the brain using organic contrast agents in the NIR-II window. At last, challenges and perspectives of organic contrast agents for NIR-II in vivo imaging are suggested. |
| first_indexed | 2024-10-01T05:32:02Z |
| format | Journal Article |
| id | ntu-10356/137172 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:32:02Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1371722023-12-29T06:49:20Z Molecular fluorescence and photoacoustic imaging in the second near-infrared optical window using organic contrast agents Jiang, Yuyan Pu, Kanyi School of Chemical and Biomedical Engineering Engineering::Chemical engineering Fluorescence Imaging Organic Nanoparticles Noninvasive near-infrared (NIR) light ranging from 650 to 1000 nm (NIR-I) is widely employed in fundamental research and clinical applications; however, a recently discovered second NIR (NIR-II) window from 1000 to 1700 nm exhibits even better deep-tissue imaging capability due to reduced photon scattering, minimized tissue autofluorescence, and increased applicable power at longer wavelengths. This review focuses on recent advances of organic contrast agents developed for in vivo fluorescence and photoacoustic imaging in the NIR-II optical window. The superiority of the NIR-II over the NIR-I window for molecular imaging is first discussed in detail, followed by discussion of fluorescence and photoacoustic imaging of cancer, vasculature, and the brain using organic contrast agents in the NIR-II window. At last, challenges and perspectives of organic contrast agents for NIR-II in vivo imaging are suggested. Accepted version 2020-03-04T07:33:21Z 2020-03-04T07:33:21Z 2018 Journal Article Jiang, Y., & Pu, K. (2018). Molecular fluorescence and photoacoustic imaging in the second near-infrared optical window using organic contrast agents. Advanced Biosystems, 2(5), 1700262-. doi:10.1002/adbi.201700262 2366-7478 https://hdl.handle.net/10356/137172 10.1002/adbi.201700262 2-s2.0-85051941137 5 2 en Advanced Biosystems This is the peer reviewed version of the following article: Jiang, Y., & Pu, K. (2018). Molecular fluorescence and photoacoustic imaging in the second near-infrared optical window using organic contrast agents. Advanced Biosystems, 2(5), 1700262-., which has been published in final form at https://doi.org/10.1002/adbi.201700262. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf |
| spellingShingle | Engineering::Chemical engineering Fluorescence Imaging Organic Nanoparticles Jiang, Yuyan Pu, Kanyi Molecular fluorescence and photoacoustic imaging in the second near-infrared optical window using organic contrast agents |
| title | Molecular fluorescence and photoacoustic imaging in the second near-infrared optical window using organic contrast agents |
| title_full | Molecular fluorescence and photoacoustic imaging in the second near-infrared optical window using organic contrast agents |
| title_fullStr | Molecular fluorescence and photoacoustic imaging in the second near-infrared optical window using organic contrast agents |
| title_full_unstemmed | Molecular fluorescence and photoacoustic imaging in the second near-infrared optical window using organic contrast agents |
| title_short | Molecular fluorescence and photoacoustic imaging in the second near-infrared optical window using organic contrast agents |
| title_sort | molecular fluorescence and photoacoustic imaging in the second near infrared optical window using organic contrast agents |
| topic | Engineering::Chemical engineering Fluorescence Imaging Organic Nanoparticles |
| url | https://hdl.handle.net/10356/137172 |
| work_keys_str_mv | AT jiangyuyan molecularfluorescenceandphotoacousticimaginginthesecondnearinfraredopticalwindowusingorganiccontrastagents AT pukanyi molecularfluorescenceandphotoacousticimaginginthesecondnearinfraredopticalwindowusingorganiccontrastagents |