A dual-function antibiotic-transporter conjugate exhibits superior activity in sterilizing MRSA biofilms and killing persister cells
New strategies are urgently needed to target MRSA, a major global health problem and the leading cause of mortality from antibiotic-resistant infections in many countries. Here, we report a general approach to this problem exemplified by the design and synthesis of a vancomycin-d-octaarginine conjug...
Main Authors: | Antonoplis, Alexandra, Zang, Xiaoyu, Huttner, Melanie A., Chong, Kelvin Kian Long, Lee, Yu B., Co, Julia Y., Amieva, Manuel R., Kline, Kimberly A., Wender, Paul A., Cegelski, Lynette |
---|---|
Other Authors: | School of Biological Sciences |
Format: | Journal Article |
Language: | English |
Published: |
2020
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/137198 |
Similar Items
-
BiOClBr-coated fabrics with enhanced antimicrobial properties under ambient light
by: Khin, Mya Mya, et al.
Published: (2022) -
Molecular evidence of a toxic effect on a biofilm and its matrix
by: Ding, Yuanzhao, et al.
Published: (2020) -
Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms
by: Andersen, Jens Bo, et al.
Published: (2021) -
Streptococcus pyogenes capsule promotes microcolony-independent biofilm formation
by: Matysik, Artur, et al.
Published: (2019) -
Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase
by: Rice, Scott A., et al.
Published: (2013)