Effect of single instillation of two hyaluronic acid-based topical lubricants on tear film thickness in patients with dry eye syndrome
Purpose: This study investigated the effect of single administration of 2 different hyaluronic acid-based topical lubricants on tear film thickness (TFT) in patients with moderate-to-severe dry eye disease (DED). Methods: Sixty patients were randomized to receive eye drops containing unpreserved sod...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | https://hdl.handle.net/10356/137360 |
| _version_ | 1811694849403912192 |
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| author | Szegedi, Stephan Scheschy, Ulrike Schmidl, Doreen Aranha dos Santos, Valentin Stegmann, Hannes Adzhemian, Narine Fondi, Klemens Bata, Ahmed M. Werkmeister, René M. Couderc, Chantal Schmetterer, Leopold Garhofer, Gerhard |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Szegedi, Stephan Scheschy, Ulrike Schmidl, Doreen Aranha dos Santos, Valentin Stegmann, Hannes Adzhemian, Narine Fondi, Klemens Bata, Ahmed M. Werkmeister, René M. Couderc, Chantal Schmetterer, Leopold Garhofer, Gerhard |
| author_sort | Szegedi, Stephan |
| collection | NTU |
| description | Purpose: This study investigated the effect of single administration of 2 different hyaluronic acid-based topical lubricants on tear film thickness (TFT) in patients with moderate-to-severe dry eye disease (DED). Methods: Sixty patients were randomized to receive eye drops containing unpreserved sodium hyaluronate, triglycerides, and phospholipids (HTP), unpreserved sodium hyaluronate (HA), or unpreserved sodium chloride (NaCl). TFT and lipid layer thickness (LLT) were assessed before and at defined time points after single instillation with a custom-built ultrahigh-resolution optical coherence tomography system and a white light interferometer. Standard tests for DED such as a visual analogue scale (VAS), corneal fluorescein staining (CFS), Schirmer I test, and tear break-up time (BUT) were performed. Results: The time course in TFT was significantly different between the 3 administered agents (P < 0.001). Single administration of HTP significantly increased TFT over a period of 40 min, an increase in TFT over 20 min was observed after instillation of HA, whereas NaCl had no effect. No significant difference in the change in BUT, CFS, or LLT was observed between the 3 groups (P = 0.57, 0.97, and 0.86, respectively). A significant improvement in subjective symptoms (VAS) was found after single instillation of HTP (P = 0.03 vs. baseline) and HA, but not after administration of NaCl (P = 0.03, P < 0.01, and P = 0.08 vs. baseline, respectively, P = 0.57 between groups). Conclusions: Single administration of HTP and HA significantly increased TFT showing a longer residence time and improved subjective symptoms, whereas instillation of NaCl had no effect. Long-term studies with multiple instillations will be necessary to further investigate the effect of the tested products on the clinical outcome. ClinicalTrials.gov ID: NCT03161080. |
| first_indexed | 2024-10-01T07:14:07Z |
| format | Journal Article |
| id | ntu-10356/137360 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:14:07Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1373602020-11-01T05:27:30Z Effect of single instillation of two hyaluronic acid-based topical lubricants on tear film thickness in patients with dry eye syndrome Szegedi, Stephan Scheschy, Ulrike Schmidl, Doreen Aranha dos Santos, Valentin Stegmann, Hannes Adzhemian, Narine Fondi, Klemens Bata, Ahmed M. Werkmeister, René M. Couderc, Chantal Schmetterer, Leopold Garhofer, Gerhard Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Dry Eye Disease Hyaluronic Acid Purpose: This study investigated the effect of single administration of 2 different hyaluronic acid-based topical lubricants on tear film thickness (TFT) in patients with moderate-to-severe dry eye disease (DED). Methods: Sixty patients were randomized to receive eye drops containing unpreserved sodium hyaluronate, triglycerides, and phospholipids (HTP), unpreserved sodium hyaluronate (HA), or unpreserved sodium chloride (NaCl). TFT and lipid layer thickness (LLT) were assessed before and at defined time points after single instillation with a custom-built ultrahigh-resolution optical coherence tomography system and a white light interferometer. Standard tests for DED such as a visual analogue scale (VAS), corneal fluorescein staining (CFS), Schirmer I test, and tear break-up time (BUT) were performed. Results: The time course in TFT was significantly different between the 3 administered agents (P < 0.001). Single administration of HTP significantly increased TFT over a period of 40 min, an increase in TFT over 20 min was observed after instillation of HA, whereas NaCl had no effect. No significant difference in the change in BUT, CFS, or LLT was observed between the 3 groups (P = 0.57, 0.97, and 0.86, respectively). A significant improvement in subjective symptoms (VAS) was found after single instillation of HTP (P = 0.03 vs. baseline) and HA, but not after administration of NaCl (P = 0.03, P < 0.01, and P = 0.08 vs. baseline, respectively, P = 0.57 between groups). Conclusions: Single administration of HTP and HA significantly increased TFT showing a longer residence time and improved subjective symptoms, whereas instillation of NaCl had no effect. Long-term studies with multiple instillations will be necessary to further investigate the effect of the tested products on the clinical outcome. ClinicalTrials.gov ID: NCT03161080. Accepted version 2020-03-18T06:55:32Z 2020-03-18T06:55:32Z 2018 Journal Article Szegedi, S., Scheschy, U., Schmidl, D., Aranha dos Santos, V., Stegmann, H., Adzhemian, N., . . . Garhofer, G. (2018). Effect of single instillation of two hyaluronic acid-based topical lubricants on tear film thickness in patients with dry eye syndrome. Journal of Ocular Pharmacology and Therapeutics, 34(9), 605-611. doi:10.1089/jop.2018.0069 1080-7683 https://hdl.handle.net/10356/137360 10.1089/jop.2018.0069 30325687 2-s2.0-85056656185 9 34 605 611 en Journal of Ocular Pharmacology and Therapeutics © 2018 Mary Ann Liebert. All rights reserved. This paper was published in Journal of Ocular Pharmacology and Therapeutics and is made available with permission of Mary Ann Liebert. Final publication is available from Mary Ann Liebert, Inc., publishers https://doi.org/10.1089/jop.2018.0069 application/pdf |
| spellingShingle | Science::Medicine Dry Eye Disease Hyaluronic Acid Szegedi, Stephan Scheschy, Ulrike Schmidl, Doreen Aranha dos Santos, Valentin Stegmann, Hannes Adzhemian, Narine Fondi, Klemens Bata, Ahmed M. Werkmeister, René M. Couderc, Chantal Schmetterer, Leopold Garhofer, Gerhard Effect of single instillation of two hyaluronic acid-based topical lubricants on tear film thickness in patients with dry eye syndrome |
| title | Effect of single instillation of two hyaluronic acid-based topical lubricants on tear film thickness in patients with dry eye syndrome |
| title_full | Effect of single instillation of two hyaluronic acid-based topical lubricants on tear film thickness in patients with dry eye syndrome |
| title_fullStr | Effect of single instillation of two hyaluronic acid-based topical lubricants on tear film thickness in patients with dry eye syndrome |
| title_full_unstemmed | Effect of single instillation of two hyaluronic acid-based topical lubricants on tear film thickness in patients with dry eye syndrome |
| title_short | Effect of single instillation of two hyaluronic acid-based topical lubricants on tear film thickness in patients with dry eye syndrome |
| title_sort | effect of single instillation of two hyaluronic acid based topical lubricants on tear film thickness in patients with dry eye syndrome |
| topic | Science::Medicine Dry Eye Disease Hyaluronic Acid |
| url | https://hdl.handle.net/10356/137360 |
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