Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design
We report a dual-focus fiber-optic probe designed to extend depth of focus (DOF) in high-resolution endoscopic optical coherence tomography. We exploited the broad spectral bandwidth of a supercontinuum source and, in the fiber probe, the foci of the 750-1000 nm and 1100-1450 nm inputs were axially...
| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/137388 |
| _version_ | 1826113114921238528 |
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| author | Li, Jinhan Luo, Yuemei Wang, Xianghong Wang, Nanshuo Bo, En Chen, Si Chen, Shufen Chen, Shi Tsai, Meng-Tsan Liu, Linbo |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Li, Jinhan Luo, Yuemei Wang, Xianghong Wang, Nanshuo Bo, En Chen, Si Chen, Shufen Chen, Shi Tsai, Meng-Tsan Liu, Linbo |
| author_sort | Li, Jinhan |
| collection | NTU |
| description | We report a dual-focus fiber-optic probe designed to extend depth of focus (DOF) in high-resolution endoscopic optical coherence tomography. We exploited the broad spectral bandwidth of a supercontinuum source and, in the fiber probe, the foci of the 750-1000 nm and 1100-1450 nm inputs were axially chromatically shifted. The interference signals from the two spectral bands were measured with a Si camera-based spectrometer and an InGaAs camera-based spectrometer, respectively. We verified the feasibility of the design using a phantom composed of microparticles and swine small intestine tissue ex vivo. The results showed that a transverse resolution below 5 μm over 300 μm could be maintained, and that the extended DOF was 2 times larger than that of the single focus probe via the use of dual spectral band inputs and a chromatic focal shift. |
| first_indexed | 2024-10-01T03:18:14Z |
| format | Journal Article |
| id | ntu-10356/137388 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:18:14Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1373882020-03-20T04:40:29Z Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design Li, Jinhan Luo, Yuemei Wang, Xianghong Wang, Nanshuo Bo, En Chen, Si Chen, Shufen Chen, Shi Tsai, Meng-Tsan Liu, Linbo School of Chemical and Biomedical Engineering School of Electrical and Electronic Engineering Engineering::Electrical and electronic engineering Optical Coherence Tomography Interferometry We report a dual-focus fiber-optic probe designed to extend depth of focus (DOF) in high-resolution endoscopic optical coherence tomography. We exploited the broad spectral bandwidth of a supercontinuum source and, in the fiber probe, the foci of the 750-1000 nm and 1100-1450 nm inputs were axially chromatically shifted. The interference signals from the two spectral bands were measured with a Si camera-based spectrometer and an InGaAs camera-based spectrometer, respectively. We verified the feasibility of the design using a phantom composed of microparticles and swine small intestine tissue ex vivo. The results showed that a transverse resolution below 5 μm over 300 μm could be maintained, and that the extended DOF was 2 times larger than that of the single focus probe via the use of dual spectral band inputs and a chromatic focal shift. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) NMRC (Natl Medical Research Council, S’pore) Accepted version 2020-03-20T04:40:29Z 2020-03-20T04:40:29Z 2018 Journal Article Li, J., Luo, Y., Wang, X., Wang, N., Bo, E., Chen, S., . . . Liu, L. (2018). Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design. Applied optics, 57(21), 6040-6046. doi:10.1364/AO.57.006040 0003-6935 https://hdl.handle.net/10356/137388 10.1364/AO.57.006040 30118032 2-s2.0-85050209523 21 57 6040 6046 en Applied Optics © 2018 Optical Society of America. All rights reserved. This paper was published in Applied Optics and is made available with permission of Optical Society of America. application/pdf |
| spellingShingle | Engineering::Electrical and electronic engineering Optical Coherence Tomography Interferometry Li, Jinhan Luo, Yuemei Wang, Xianghong Wang, Nanshuo Bo, En Chen, Si Chen, Shufen Chen, Shi Tsai, Meng-Tsan Liu, Linbo Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design |
| title | Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design |
| title_full | Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design |
| title_fullStr | Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design |
| title_full_unstemmed | Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design |
| title_short | Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design |
| title_sort | extending the depth of focus of fiber optic optical coherence tomography using a chromatic dual focus design |
| topic | Engineering::Electrical and electronic engineering Optical Coherence Tomography Interferometry |
| url | https://hdl.handle.net/10356/137388 |
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