Independent of EPR effect : a smart delivery nanosystem for tracking and treatment of nonvascularized intra-abdominal metastases
Nanoparticle-based delivery systems (NDS) have impacted the field of cancer therapy on account of the enhanced permeability and retention (EPR) effect that promotes passive accumulation in tumors through the tumor vasculature after intravenous (IV) administration. However, transplanted tumor xenogra...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/137602 |
| _version_ | 1811692308740964352 |
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| author | Zhao, Lingzhi Yuan, Wei Li, Junyao Yang, Liqiang Su, Yaoquan Peng, Juanjuan Chen, Rui Tham, Phoebe Huijun Chen, Hongzhong Lim, Wei Qi Xiang, Huijing Xing, Pengyao Li, Fuyou Zhao, Yanli |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Zhao, Lingzhi Yuan, Wei Li, Junyao Yang, Liqiang Su, Yaoquan Peng, Juanjuan Chen, Rui Tham, Phoebe Huijun Chen, Hongzhong Lim, Wei Qi Xiang, Huijing Xing, Pengyao Li, Fuyou Zhao, Yanli |
| author_sort | Zhao, Lingzhi |
| collection | NTU |
| description | Nanoparticle-based delivery systems (NDS) have impacted the field of cancer therapy on account of the enhanced permeability and retention (EPR) effect that promotes passive accumulation in tumors through the tumor vasculature after intravenous (IV) administration. However, transplanted tumor xenografts on animal models used to justify the feasibility of EPR effect are quite different from clinical tumors in many aspects, a fact that becomes an impediment for NDS to succeed clinical trials. Particularly, early-stage tumor metastases are usually nonvascularized and incapable of conforming the EPR effect after IV injection. Therefore, it is necessary to develop smart NDS to deliver drugs in an EPR-independent route. Herein, an NDS-based treatment approach for intra-abdominal metastases from ovarian carcinoma is reported. Instead of IV injection, intraperitoneal (IP) injection was
employed to directly apply the NDS to the metastatic lesions. The NDS was tailor-made with targeting groups to actively target the tumor nidus and redox-responsive drug release to reduce systematic toxicity. Comparing with IV administration, the IP injected NDS could be enriched in metastatic tumor more efficiently, leading to superior therapeutic outcome in vivo. This study provides a successful protocol of EPR independent NDS-based cancer treatment, which may facilitate the clinical translation of nanoparticle-based cancer therapeutics. |
| first_indexed | 2024-10-01T06:33:44Z |
| format | Journal Article |
| id | ntu-10356/137602 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:33:44Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1376022023-02-28T19:46:49Z Independent of EPR effect : a smart delivery nanosystem for tracking and treatment of nonvascularized intra-abdominal metastases Zhao, Lingzhi Yuan, Wei Li, Junyao Yang, Liqiang Su, Yaoquan Peng, Juanjuan Chen, Rui Tham, Phoebe Huijun Chen, Hongzhong Lim, Wei Qi Xiang, Huijing Xing, Pengyao Li, Fuyou Zhao, Yanli School of Physical and Mathematical Sciences Science::Chemistry Nanomedicine Nanocarrier Nanoparticle-based delivery systems (NDS) have impacted the field of cancer therapy on account of the enhanced permeability and retention (EPR) effect that promotes passive accumulation in tumors through the tumor vasculature after intravenous (IV) administration. However, transplanted tumor xenografts on animal models used to justify the feasibility of EPR effect are quite different from clinical tumors in many aspects, a fact that becomes an impediment for NDS to succeed clinical trials. Particularly, early-stage tumor metastases are usually nonvascularized and incapable of conforming the EPR effect after IV injection. Therefore, it is necessary to develop smart NDS to deliver drugs in an EPR-independent route. Herein, an NDS-based treatment approach for intra-abdominal metastases from ovarian carcinoma is reported. Instead of IV injection, intraperitoneal (IP) injection was employed to directly apply the NDS to the metastatic lesions. The NDS was tailor-made with targeting groups to actively target the tumor nidus and redox-responsive drug release to reduce systematic toxicity. Comparing with IV administration, the IP injected NDS could be enriched in metastatic tumor more efficiently, leading to superior therapeutic outcome in vivo. This study provides a successful protocol of EPR independent NDS-based cancer treatment, which may facilitate the clinical translation of nanoparticle-based cancer therapeutics. NRF (Natl Research Foundation, S’pore) Accepted version 2020-04-06T04:11:23Z 2020-04-06T04:11:23Z 2018 Journal Article Zhao, L., Yuan, W., Li, J., Yang, L., Su, Y., Peng, J., ... Zhao, Y. (2018). Independent of EPR effect : a smart delivery nanosystem for tracking and treatment of nonvascularized intra-abdominal metastases. Advanced Functional Materials, 28(50), 1806162. doi:10.1002/adfm.201806162 1616-301X https://hdl.handle.net/10356/137602 10.1002/adfm.201806162 50 28 1806162 en Advanced Functional Materials This is the peer reviewed version of the following article: Zhao, L., Yuan, W., Li, J., Yang, L., Su, Y., Peng, J., ... Zhao, Y. (2018). Independent of EPR effect : a smart delivery nanosystem for tracking and treatment of nonvascularized intra-abdominal metastases. Advanced Functional Materials, 28(50), 1806162. doi:10.1002/adfm.201806162, which has been published in final form at 10.1002/adfm.201806162. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf |
| spellingShingle | Science::Chemistry Nanomedicine Nanocarrier Zhao, Lingzhi Yuan, Wei Li, Junyao Yang, Liqiang Su, Yaoquan Peng, Juanjuan Chen, Rui Tham, Phoebe Huijun Chen, Hongzhong Lim, Wei Qi Xiang, Huijing Xing, Pengyao Li, Fuyou Zhao, Yanli Independent of EPR effect : a smart delivery nanosystem for tracking and treatment of nonvascularized intra-abdominal metastases |
| title | Independent of EPR effect : a smart delivery nanosystem for tracking and treatment of nonvascularized intra-abdominal metastases |
| title_full | Independent of EPR effect : a smart delivery nanosystem for tracking and treatment of nonvascularized intra-abdominal metastases |
| title_fullStr | Independent of EPR effect : a smart delivery nanosystem for tracking and treatment of nonvascularized intra-abdominal metastases |
| title_full_unstemmed | Independent of EPR effect : a smart delivery nanosystem for tracking and treatment of nonvascularized intra-abdominal metastases |
| title_short | Independent of EPR effect : a smart delivery nanosystem for tracking and treatment of nonvascularized intra-abdominal metastases |
| title_sort | independent of epr effect a smart delivery nanosystem for tracking and treatment of nonvascularized intra abdominal metastases |
| topic | Science::Chemistry Nanomedicine Nanocarrier |
| url | https://hdl.handle.net/10356/137602 |
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