NIR-light-activated combination therapy with a precise ratio of photosensitizer and prodrug using a host-guest strategy
The co-delivery of photosensitizers with prodrugs sensitive to reactive oxygen species (ROS) for light-triggered ROS generation and cascaded prodrug activation has drawn tremendous attention. However, the absence of a feasible method to deliver the two components at a precise ratio has impaired the...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | https://hdl.handle.net/10356/137650 |
| _version_ | 1811693168908828672 |
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| author | Chen, Hongzhong Zeng, Xiaowei Tham, Phoebe Huijun Phua, Fiona Soo Zeng Cheng, Wei Zeng, Wenfeng Shi, Haoran Mei, Lin Zhao, Yanli |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Chen, Hongzhong Zeng, Xiaowei Tham, Phoebe Huijun Phua, Fiona Soo Zeng Cheng, Wei Zeng, Wenfeng Shi, Haoran Mei, Lin Zhao, Yanli |
| author_sort | Chen, Hongzhong |
| collection | NTU |
| description | The co-delivery of photosensitizers with prodrugs sensitive to reactive oxygen species (ROS) for light-triggered ROS generation and cascaded prodrug activation has drawn tremendous attention. However, the absence of a feasible method to deliver the two components at a precise ratio has impaired the application potential. Herein, we report an efficient method to produce a nanosized platform for the delivery of an optimized ratio of the two components by the means of host–guest strategy for maximizing the combination therapy efficacy of cancer treatment. The key features of this host–guest strategy for the combination therapy are that the ratio between photosensitizer and ROS-sensitive prodrug can be easily tuned, near-infrared (NIR) irradiation can sensitize the photosensitizer and activate the paclitaxel prodrug for its release, and the accumulation process can be tracked by NIR imaging to maximize the efficacy of photodynamic and chemotherapy. |
| first_indexed | 2024-10-01T06:47:24Z |
| format | Journal Article |
| id | ntu-10356/137650 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:47:24Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1376502023-02-28T19:46:40Z NIR-light-activated combination therapy with a precise ratio of photosensitizer and prodrug using a host-guest strategy Chen, Hongzhong Zeng, Xiaowei Tham, Phoebe Huijun Phua, Fiona Soo Zeng Cheng, Wei Zeng, Wenfeng Shi, Haoran Mei, Lin Zhao, Yanli School of Physical and Mathematical Sciences Science::Chemistry Nanomedicine Cancer Therapy The co-delivery of photosensitizers with prodrugs sensitive to reactive oxygen species (ROS) for light-triggered ROS generation and cascaded prodrug activation has drawn tremendous attention. However, the absence of a feasible method to deliver the two components at a precise ratio has impaired the application potential. Herein, we report an efficient method to produce a nanosized platform for the delivery of an optimized ratio of the two components by the means of host–guest strategy for maximizing the combination therapy efficacy of cancer treatment. The key features of this host–guest strategy for the combination therapy are that the ratio between photosensitizer and ROS-sensitive prodrug can be easily tuned, near-infrared (NIR) irradiation can sensitize the photosensitizer and activate the paclitaxel prodrug for its release, and the accumulation process can be tracked by NIR imaging to maximize the efficacy of photodynamic and chemotherapy. NRF (Natl Research Foundation, S’pore) ASTAR (Agency for Sci., Tech. and Research, S’pore) MOE (Min. of Education, S’pore) Accepted version 2020-04-07T08:58:20Z 2020-04-07T08:58:20Z 2019 Journal Article Chen, H., Zeng, X., Tham, P. H., Phua, F. S. Z., Cheng, W., Zeng, W., ... Zhao, Y. (2019). NIR-light-activated combination therapy with a precise ratio of photosensitizer and prodrug using a host-guest strategy. Angewandte Chemie International Edition, 7641-7646. doi:10.1002/anie.201900886 1433-7851 https://hdl.handle.net/10356/137650 10.1002/anie.201900886 23 58 7641 7646 en Angewandte Chemie International Edition This is the peer reviewed version of the following article: Chen, H., Zeng, X., Tham, P. H., Phua, F. S. Z., Cheng, W., Zeng, W., ... Zhao, Y. (2019). NIR-light-activated combination therapy with a precise ratio of photosensitizer and prodrug using a host-guest strategy. Angewandte Chemie International Edition, 7641-7646. doi:10.1002/anie.201900886, which has been published in final form at 10.1002/anie.201900886. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf |
| spellingShingle | Science::Chemistry Nanomedicine Cancer Therapy Chen, Hongzhong Zeng, Xiaowei Tham, Phoebe Huijun Phua, Fiona Soo Zeng Cheng, Wei Zeng, Wenfeng Shi, Haoran Mei, Lin Zhao, Yanli NIR-light-activated combination therapy with a precise ratio of photosensitizer and prodrug using a host-guest strategy |
| title | NIR-light-activated combination therapy with a precise ratio of photosensitizer and prodrug using a host-guest strategy |
| title_full | NIR-light-activated combination therapy with a precise ratio of photosensitizer and prodrug using a host-guest strategy |
| title_fullStr | NIR-light-activated combination therapy with a precise ratio of photosensitizer and prodrug using a host-guest strategy |
| title_full_unstemmed | NIR-light-activated combination therapy with a precise ratio of photosensitizer and prodrug using a host-guest strategy |
| title_short | NIR-light-activated combination therapy with a precise ratio of photosensitizer and prodrug using a host-guest strategy |
| title_sort | nir light activated combination therapy with a precise ratio of photosensitizer and prodrug using a host guest strategy |
| topic | Science::Chemistry Nanomedicine Cancer Therapy |
| url | https://hdl.handle.net/10356/137650 |
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