A mesoporous nanoenzyme derived from metal–organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced photodynamic therapy
Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as the local oxygen concentration plays an important role in the generation of cytotoxic singlet oxygen (1O2). Herein, a versatile mesoporous nanoenzyme (NE) derived from metal–organic frameworks (MOFs) is presented f...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/137688 |
| _version_ | 1811693105972248576 |
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| author | Wang, Dongdong Wu, Huihui Lim, Wei Qi Phua, Fiona Soo Zeng Xu, Pengping Chen, Qianwang Guo, Zhen Zhao, Yanli |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Wang, Dongdong Wu, Huihui Lim, Wei Qi Phua, Fiona Soo Zeng Xu, Pengping Chen, Qianwang Guo, Zhen Zhao, Yanli |
| author_sort | Wang, Dongdong |
| collection | NTU |
| description | Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as the local oxygen concentration plays an important role in the generation of cytotoxic singlet oxygen (1O2). Herein, a versatile mesoporous nanoenzyme (NE) derived from metal–organic frameworks (MOFs) is presented for in situ generation of endogenous O2 to enhance the PDT efficacy under bioimaging guidance. The mesoporous NE is constructed by first coating a manganese-based MOFs with mesoporous silica, followed by a facile annealing process under the ambient atmosphere. After removing the mesoporous silica shell and post-modifying with polydopamine and poly(ethylene glycol) for improving the biocompatibility, the obtained mesoporous NE is loaded with chlorin e6 (Ce6), a commonly used photosensitizer in PDT, with a high loading capacity. Upon the O2 generation through the catalytic reaction between the catalytic amount NE and the endogenous H2O2, the hypoxic tumor microenvironment is relieved. Thus, Ce6-loaded NE serves as a H2O2-activated oxygen supplier to increase the local O2 concentration for significantly enhanced antitumor PDT efficacy in vitro and in vivo. In addition, the NE also shows T2-weighted magnetic resonance imaging ability for its in vivo tracking. This work presents an interesting biomedical use of MOF-derived mesoporous NE as a multifunctional theranostic agent in cancer therapy. |
| first_indexed | 2024-10-01T06:46:24Z |
| format | Journal Article |
| id | ntu-10356/137688 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:46:24Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1376882023-02-28T19:46:47Z A mesoporous nanoenzyme derived from metal–organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced photodynamic therapy Wang, Dongdong Wu, Huihui Lim, Wei Qi Phua, Fiona Soo Zeng Xu, Pengping Chen, Qianwang Guo, Zhen Zhao, Yanli School of Physical and Mathematical Sciences Science::Chemistry Endogenous Oxygenation Nanomedicine Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as the local oxygen concentration plays an important role in the generation of cytotoxic singlet oxygen (1O2). Herein, a versatile mesoporous nanoenzyme (NE) derived from metal–organic frameworks (MOFs) is presented for in situ generation of endogenous O2 to enhance the PDT efficacy under bioimaging guidance. The mesoporous NE is constructed by first coating a manganese-based MOFs with mesoporous silica, followed by a facile annealing process under the ambient atmosphere. After removing the mesoporous silica shell and post-modifying with polydopamine and poly(ethylene glycol) for improving the biocompatibility, the obtained mesoporous NE is loaded with chlorin e6 (Ce6), a commonly used photosensitizer in PDT, with a high loading capacity. Upon the O2 generation through the catalytic reaction between the catalytic amount NE and the endogenous H2O2, the hypoxic tumor microenvironment is relieved. Thus, Ce6-loaded NE serves as a H2O2-activated oxygen supplier to increase the local O2 concentration for significantly enhanced antitumor PDT efficacy in vitro and in vivo. In addition, the NE also shows T2-weighted magnetic resonance imaging ability for its in vivo tracking. This work presents an interesting biomedical use of MOF-derived mesoporous NE as a multifunctional theranostic agent in cancer therapy. NRF (Natl Research Foundation, S’pore) Accepted version 2020-04-08T08:11:47Z 2020-04-08T08:11:47Z 2019 Journal Article Wang, D., Wu, H., Lim, W. Q., Phua, F. S. Z., Xu, P., Chen, Q., ... Zhao, Y. (2019). A mesoporous nanoenzyme derived from metal–organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced photodynamic therapy. Advanced Materials, 31(27), 1901893-. doi:10.1002/adma.201901893 0935-9648 https://hdl.handle.net/10356/137688 10.1002/adma.201901893 27 31 1901893 en Advanced Materials This is the peer reviewed version of the following article:Wang, D., Wu, H., Lim, W. Q., Phua, F. S. Z., Xu, P., Chen, Q., ... Zhao, Y. (2019). A mesoporous nanoenzyme derived from metal–organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced photodynamic therapy. Advanced Materials, 31(27), 1901893-. doi:10.1002/adma.201901893, which has been published in final form at 10.1002/adma.201901893. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf |
| spellingShingle | Science::Chemistry Endogenous Oxygenation Nanomedicine Wang, Dongdong Wu, Huihui Lim, Wei Qi Phua, Fiona Soo Zeng Xu, Pengping Chen, Qianwang Guo, Zhen Zhao, Yanli A mesoporous nanoenzyme derived from metal–organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced photodynamic therapy |
| title | A mesoporous nanoenzyme derived from metal–organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced photodynamic therapy |
| title_full | A mesoporous nanoenzyme derived from metal–organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced photodynamic therapy |
| title_fullStr | A mesoporous nanoenzyme derived from metal–organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced photodynamic therapy |
| title_full_unstemmed | A mesoporous nanoenzyme derived from metal–organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced photodynamic therapy |
| title_short | A mesoporous nanoenzyme derived from metal–organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced photodynamic therapy |
| title_sort | mesoporous nanoenzyme derived from metal organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced photodynamic therapy |
| topic | Science::Chemistry Endogenous Oxygenation Nanomedicine |
| url | https://hdl.handle.net/10356/137688 |
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