Engineering of electrochromic materials as activatable probes for molecular imaging and photodynamic therapy
Electrochromic materials (EMs) are widely used color-switchable materials, but their applications as stimuli-responsive biomaterials to monitor and control biological processes remain unexplored. This study reports the engineering of an organic π-electron structure-based EM (dicationic 1,1,4,4-tetra...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/137696 |
| _version_ | 1811694439264944128 |
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| author | Wu, Luyan Sun, Yidan Sugimoto, Keisuke Luo, Zhiliang Ishigaki, Yusuke Pu, Kanyi Suzuki, Takanori Chen, Hong-Yuan Ye, Deju |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Wu, Luyan Sun, Yidan Sugimoto, Keisuke Luo, Zhiliang Ishigaki, Yusuke Pu, Kanyi Suzuki, Takanori Chen, Hong-Yuan Ye, Deju |
| author_sort | Wu, Luyan |
| collection | NTU |
| description | Electrochromic materials (EMs) are widely used color-switchable materials, but their applications as stimuli-responsive biomaterials to monitor and control biological processes remain unexplored. This study reports the engineering of an organic π-electron structure-based EM (dicationic 1,1,4,4-tetraarylbutadiene, 12+) as a unique hydrogen sulfide (H2S)-responsive chromophore amenable to build H2S-activatable fluorescent probes (12+-semiconducting polymer nanoparticles, 12+-SNPs) for in vivo H2S detection. We demonstrate that EM 12+, with a strong absorption (500–850 nm), efficiently quenches the fluorescence (580, 700, or 830 nm) of different fluorophores within 12+-SNPs, while the selective conversion into colorless diene 2 via H2S-mediated two-electron reduction significantly recovers fluorescence, allowing for non-invasive imaging of hepatic and tumor H2S in mice in real time. Strikingly, EM 12+ is further applied to design a near-infrared photosensitizer with tumor-targeting and H2S-activatable ability for effective photodynamic therapy (PDT) of H2S-related tumors in mice. This study demonstrates promise for applying EMs to build activatable probes for molecular imaging of H2S and selective PDT of tumors, which may lead to the development of new EMs capable of detecting and regulating essential biological processes in vivo. |
| first_indexed | 2024-10-01T07:07:35Z |
| format | Journal Article |
| id | ntu-10356/137696 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:07:35Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1376962020-04-09T02:32:14Z Engineering of electrochromic materials as activatable probes for molecular imaging and photodynamic therapy Wu, Luyan Sun, Yidan Sugimoto, Keisuke Luo, Zhiliang Ishigaki, Yusuke Pu, Kanyi Suzuki, Takanori Chen, Hong-Yuan Ye, Deju School of Chemical and Biomedical Engineering Engineering::Chemical engineering Anatomy Fluorescence Electrochromic materials (EMs) are widely used color-switchable materials, but their applications as stimuli-responsive biomaterials to monitor and control biological processes remain unexplored. This study reports the engineering of an organic π-electron structure-based EM (dicationic 1,1,4,4-tetraarylbutadiene, 12+) as a unique hydrogen sulfide (H2S)-responsive chromophore amenable to build H2S-activatable fluorescent probes (12+-semiconducting polymer nanoparticles, 12+-SNPs) for in vivo H2S detection. We demonstrate that EM 12+, with a strong absorption (500–850 nm), efficiently quenches the fluorescence (580, 700, or 830 nm) of different fluorophores within 12+-SNPs, while the selective conversion into colorless diene 2 via H2S-mediated two-electron reduction significantly recovers fluorescence, allowing for non-invasive imaging of hepatic and tumor H2S in mice in real time. Strikingly, EM 12+ is further applied to design a near-infrared photosensitizer with tumor-targeting and H2S-activatable ability for effective photodynamic therapy (PDT) of H2S-related tumors in mice. This study demonstrates promise for applying EMs to build activatable probes for molecular imaging of H2S and selective PDT of tumors, which may lead to the development of new EMs capable of detecting and regulating essential biological processes in vivo. 2020-04-09T02:32:14Z 2020-04-09T02:32:14Z 2018 Journal Article Wu, L., Sun, Y., Sugimoto, K., Luo, Z., Ishigaki, Y., Pu, K., . . . Ye, D. (2018). Engineering of electrochromic materials as activatable probes for molecular imaging and photodynamic therapy. Journal of the American Chemical Society, 140(47), 16340-16352. doi:10.1021/jacs.8b10176 0002-7863 https://hdl.handle.net/10356/137696 10.1021/jacs.8b10176 30384600 2-s2.0-85056714292 47 140 16340 16352 en Journal of the American Chemical Society © 2018 American Chemical Society. All rights reserved. |
| spellingShingle | Engineering::Chemical engineering Anatomy Fluorescence Wu, Luyan Sun, Yidan Sugimoto, Keisuke Luo, Zhiliang Ishigaki, Yusuke Pu, Kanyi Suzuki, Takanori Chen, Hong-Yuan Ye, Deju Engineering of electrochromic materials as activatable probes for molecular imaging and photodynamic therapy |
| title | Engineering of electrochromic materials as activatable probes for molecular imaging and photodynamic therapy |
| title_full | Engineering of electrochromic materials as activatable probes for molecular imaging and photodynamic therapy |
| title_fullStr | Engineering of electrochromic materials as activatable probes for molecular imaging and photodynamic therapy |
| title_full_unstemmed | Engineering of electrochromic materials as activatable probes for molecular imaging and photodynamic therapy |
| title_short | Engineering of electrochromic materials as activatable probes for molecular imaging and photodynamic therapy |
| title_sort | engineering of electrochromic materials as activatable probes for molecular imaging and photodynamic therapy |
| topic | Engineering::Chemical engineering Anatomy Fluorescence |
| url | https://hdl.handle.net/10356/137696 |
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