Temperature-directed micellar morphological transformation using CABC-block copolymers and its applications in encapsulation and hidden segment
A temperature-directed micellar morphological transformation was developed using CABC multi-block copolymers with a hydrophobic block A, a hydrophilic block B, and a thermally responsive block C with a lower critical solution temperature (LCST). The micellar structure was switched from a star (below...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/137713 |
| _version_ | 1811676950423404544 |
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| author | Zheng, Jie Chen, Chen Goto, Atsushi |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Zheng, Jie Chen, Chen Goto, Atsushi |
| author_sort | Zheng, Jie |
| collection | NTU |
| description | A temperature-directed micellar morphological transformation was developed using CABC multi-block copolymers with a hydrophobic block A, a hydrophilic block B, and a thermally responsive block C with a lower critical solution temperature (LCST). The micellar structure was switched from a star (below LCST) to a flower (above LCST). The transition temperature was tunable in a wide range (11-90 °C) by varying the C monomer composition. The large difference in the loading capacity between the star and flower enabled efficient encapsulation and controlled release of external molecules. Unlike conventional systems, the present star-to-flower transformation keeps micellar structures and hence does not liberate polymers but only external molecules selectively. Another application is a hidden functional segment. A functional segment is hidden (shielded) below the LCST and exposed to interact with external molecules or surfaces above the LCST. |
| first_indexed | 2024-10-01T02:29:37Z |
| format | Journal Article |
| id | ntu-10356/137713 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:29:37Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1377132023-02-28T19:21:05Z Temperature-directed micellar morphological transformation using CABC-block copolymers and its applications in encapsulation and hidden segment Zheng, Jie Chen, Chen Goto, Atsushi School of Physical and Mathematical Sciences Science::Chemistry Block Copolymers Encapsulation A temperature-directed micellar morphological transformation was developed using CABC multi-block copolymers with a hydrophobic block A, a hydrophilic block B, and a thermally responsive block C with a lower critical solution temperature (LCST). The micellar structure was switched from a star (below LCST) to a flower (above LCST). The transition temperature was tunable in a wide range (11-90 °C) by varying the C monomer composition. The large difference in the loading capacity between the star and flower enabled efficient encapsulation and controlled release of external molecules. Unlike conventional systems, the present star-to-flower transformation keeps micellar structures and hence does not liberate polymers but only external molecules selectively. Another application is a hidden functional segment. A functional segment is hidden (shielded) below the LCST and exposed to interact with external molecules or surfaces above the LCST. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) Accepted version 2020-04-09T06:23:30Z 2020-04-09T06:23:30Z 2020 Journal Article Zheng, J., Chen, C., & Goto, A. (2019). Temperature-directed micellar morphological transformation using CABC-block copolymers and its applications in encapsulation and hidden segment. Angewandte Chemie (International edition), 59(5), 1941-1949. doi:10.1002/anie.201913988 1433-7851 https://hdl.handle.net/10356/137713 10.1002/anie.201913988 31733019 2-s2.0-85076862271 5 59 1941 1949 en Angewandte Chemie (International edition) © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved. This paper was published in Angewandte Chemie (International edition) and is made available with permission of Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. application/pdf |
| spellingShingle | Science::Chemistry Block Copolymers Encapsulation Zheng, Jie Chen, Chen Goto, Atsushi Temperature-directed micellar morphological transformation using CABC-block copolymers and its applications in encapsulation and hidden segment |
| title | Temperature-directed micellar morphological transformation using CABC-block copolymers and its applications in encapsulation and hidden segment |
| title_full | Temperature-directed micellar morphological transformation using CABC-block copolymers and its applications in encapsulation and hidden segment |
| title_fullStr | Temperature-directed micellar morphological transformation using CABC-block copolymers and its applications in encapsulation and hidden segment |
| title_full_unstemmed | Temperature-directed micellar morphological transformation using CABC-block copolymers and its applications in encapsulation and hidden segment |
| title_short | Temperature-directed micellar morphological transformation using CABC-block copolymers and its applications in encapsulation and hidden segment |
| title_sort | temperature directed micellar morphological transformation using cabc block copolymers and its applications in encapsulation and hidden segment |
| topic | Science::Chemistry Block Copolymers Encapsulation |
| url | https://hdl.handle.net/10356/137713 |
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