Carbene-catalyzed enantioselective addition of thioamides to bromoenals for access to thiazinone heterocycles
A carbene-catalyzed reaction between α-bromoenals and thioamides was developed. Key steps include enantioselective 1,4-addition of thioamide sulfur atoms to α,β-unsaturated acyl azolium intermediate. Subsequent intramolecular annulation eventually affords thiazinone heterocycles with high optical pu...
| Главные авторы: | , , , , , |
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| Другие авторы: | |
| Формат: | Journal Article |
| Язык: | English |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://hdl.handle.net/10356/137760 |