Carbene-catalyzed enantioselective addition of thioamides to bromoenals for access to thiazinone heterocycles
A carbene-catalyzed reaction between α-bromoenals and thioamides was developed. Key steps include enantioselective 1,4-addition of thioamide sulfur atoms to α,β-unsaturated acyl azolium intermediate. Subsequent intramolecular annulation eventually affords thiazinone heterocycles with high optical pu...
| Hoofdauteurs: | , , , , , |
|---|---|
| Andere auteurs: | |
| Formaat: | Journal Article |
| Taal: | English |
| Gepubliceerd in: |
2020
|
| Onderwerpen: | |
| Online toegang: | https://hdl.handle.net/10356/137760 |