Carbene-catalyzed enantioselective addition of thioamides to bromoenals for access to thiazinone heterocycles
A carbene-catalyzed reaction between α-bromoenals and thioamides was developed. Key steps include enantioselective 1,4-addition of thioamide sulfur atoms to α,β-unsaturated acyl azolium intermediate. Subsequent intramolecular annulation eventually affords thiazinone heterocycles with high optical pu...
| Những tác giả chính: | , , , , , |
|---|---|
| Tác giả khác: | |
| Định dạng: | Journal Article |
| Ngôn ngữ: | English |
| Được phát hành: |
2020
|
| Những chủ đề: | |
| Truy cập trực tuyến: | https://hdl.handle.net/10356/137760 |