How convergent and divergent signaling pathways are mediated by card-card interactions
PRRs play an essential role in detecting pathogenic infections and propagating such immune signals to downstream effectors. NLRs act as a classic subfamily of PRRs, including NOD1/NOD2 and NLRC4. NOD1 and NOD2 share a same adaptor protein – RIP2 – that is critical for downstream signaling. The CARD...
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| Format: | Thesis-Doctor of Philosophy |
| Langue: | English |
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Nanyang Technological University
2020
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| Accès en ligne: | https://hdl.handle.net/10356/137877 |