Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates
By facilitating formation of the acyl–enzyme intermediate, peptide thioesters can largely promote subtiligase-catalyzed ligation reactions over their ester counterparts. This offers a significant addition to the repertoire of enzymatic methods for protein chemical synthesis and modification.
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/138242 |
| _version_ | 1811689066699161600 |
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| author | Tan, Xiaohong Yang, Renliang Liu, Chuan-Fa |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Tan, Xiaohong Yang, Renliang Liu, Chuan-Fa |
| author_sort | Tan, Xiaohong |
| collection | NTU |
| description | By facilitating formation of the acyl–enzyme intermediate, peptide thioesters can largely promote subtiligase-catalyzed ligation reactions over their ester counterparts. This offers a significant addition to the repertoire of enzymatic methods for protein chemical synthesis and modification. |
| first_indexed | 2024-10-01T05:42:12Z |
| format | Journal Article |
| id | ntu-10356/138242 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:42:12Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1382422020-04-29T08:18:57Z Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates Tan, Xiaohong Yang, Renliang Liu, Chuan-Fa School of Biological Sciences Science::Biological sciences Peptide Thioester Ligation By facilitating formation of the acyl–enzyme intermediate, peptide thioesters can largely promote subtiligase-catalyzed ligation reactions over their ester counterparts. This offers a significant addition to the repertoire of enzymatic methods for protein chemical synthesis and modification. MOE (Min. of Education, S’pore) 2020-04-29T08:18:57Z 2020-04-29T08:18:57Z 2018 Journal Article Tan, X., Yang, R., & Liu, C.-F. (2018). Facilitating subtiligase-catalyzed peptide ligation reactions by using peptide thioester substrates. Organic Letters, 20(21), 6691-6694. doi:10.1021/acs.orglett.8b02747 1523-7060 https://hdl.handle.net/10356/138242 10.1021/acs.orglett.8b02747 30350676 2-s2.0-85055124833 21 20 6691 6694 en Organic Letters © 2018 American Chemical Society. All rights reserved. |
| spellingShingle | Science::Biological sciences Peptide Thioester Ligation Tan, Xiaohong Yang, Renliang Liu, Chuan-Fa Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates |
| title | Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates |
| title_full | Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates |
| title_fullStr | Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates |
| title_full_unstemmed | Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates |
| title_short | Facilitating subtiligase-catalyzed peptide pigation reactions by using peptide thioester substrates |
| title_sort | facilitating subtiligase catalyzed peptide pigation reactions by using peptide thioester substrates |
| topic | Science::Biological sciences Peptide Thioester Ligation |
| url | https://hdl.handle.net/10356/138242 |
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