Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines
A carbene-catalyzed LUMO activation of a,b-unsaturated alkyne esters is reported. This catalytic process allows for effective reactions of alkyne esters with enamides to synthesize functional pyridines via simple protocols. A previously unexplored unsaturated alkyne acyl azolium intermediate is invo...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/138302 |
| _version_ | 1824453895408058368 |
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| author | Mou, Chengli Wu, Jichang Huang, Zhijian Sun, Jun Jin, Zhichao Chi, Robin Yonggui |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Mou, Chengli Wu, Jichang Huang, Zhijian Sun, Jun Jin, Zhichao Chi, Robin Yonggui |
| author_sort | Mou, Chengli |
| collection | NTU |
| description | A carbene-catalyzed LUMO activation of a,b-unsaturated alkyne esters is reported. This catalytic process allows for effective reactions of alkyne esters with enamides to synthesize functional pyridines via simple protocols. A previously unexplored unsaturated alkyne acyl azolium intermediate is involved in the key step of the reaction. |
| first_indexed | 2025-02-19T03:13:41Z |
| format | Journal Article |
| id | ntu-10356/138302 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:13:41Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1383022023-02-28T19:25:21Z Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines Mou, Chengli Wu, Jichang Huang, Zhijian Sun, Jun Jin, Zhichao Chi, Robin Yonggui School of Physical and Mathematical Sciences Science::Chemistry::Organic chemistry Pyridines NHC Catalyst A carbene-catalyzed LUMO activation of a,b-unsaturated alkyne esters is reported. This catalytic process allows for effective reactions of alkyne esters with enamides to synthesize functional pyridines via simple protocols. A previously unexplored unsaturated alkyne acyl azolium intermediate is involved in the key step of the reaction. NRF (Natl Research Foundation, S’pore) ASTAR (Agency for Sci., Tech. and Research, S’pore) MOE (Min. of Education, S’pore) Accepted version 2020-04-30T06:59:45Z 2020-04-30T06:59:45Z 2017 Journal Article Mou, C., Wu, J., Huang, Z., Sun, J., Jin, Z., & Chi, R. Y. (2017). Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridine. Chemical Communications, 53(100), 13359-13362. doi:10.1039/C7CC08039E 1359-7345 https://hdl.handle.net/10356/138302 10.1039/C7CC08039E 100 53 13359 13362 en Chemical Communications © 2017 The Royal Society of Chemistry. All rights reserved. This paper was published in Chemical Communications and is made available with permission of The Royal Society of Chemistry. application/pdf |
| spellingShingle | Science::Chemistry::Organic chemistry Pyridines NHC Catalyst Mou, Chengli Wu, Jichang Huang, Zhijian Sun, Jun Jin, Zhichao Chi, Robin Yonggui Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines |
| title | Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines |
| title_full | Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines |
| title_fullStr | Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines |
| title_full_unstemmed | Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines |
| title_short | Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines |
| title_sort | carbene catalyzed lumo activation of alkyne esters for access to functional pyridines |
| topic | Science::Chemistry::Organic chemistry Pyridines NHC Catalyst |
| url | https://hdl.handle.net/10356/138302 |
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