TBAJ-876 retains bedaquiline’s activity against subunits c and ε of mycobacterium tuberculosis F-ATP synthase

TBAJ-876 retains bedaquiline’s activity against subunits c and ε of mycobacterium tuberculosis F-ATP synthase

The antituberculosis drug bedaquiline (BDQ) inhibits Mycobacterium tuberculosis F-ATP synthase by interfering with two subunits. Drug binding to the c subunit stalls the rotation of the c ring, while binding to the ε subunit blocks coupling of c ring rotation to ATP synthesis at the catalytic α3:β3...

Olles dieđut

Bibliográfalaš dieđut
Váldodahkkit: Sarathy, Jickky Palmae, Ragunathan, Priya, Shin, Joon, Cooper, Christopher B., Upton, Anna M., Grüber, Gerhard, Dick, Thomas
Eará dahkkit: School of Biological Sciences
Materiálatiipa: Journal Article
Giella:English
Almmustuhtton: 2020
Fáttát:
Science::Biological sciences::Molecular biology
Science::Biological sciences::Biochemistry
ε Subunit
F-ATP Synthase
Liŋkkat:https://hdl.handle.net/10356/138452

Interneahtta

https://hdl.handle.net/10356/138452

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