Direct substitution of secondary and tertiary alcohols to generate sulfones under catalyst- and additive-free conditions

Direct substitution of secondary and tertiary alcohols to generate sulfones under catalyst- and additive-free conditions

An environmentally benign protocol that affords propargylic sulfones containing highly congested carbon centers from easily accessible alcohols and sulfinic acids with water as the only byproduct is reported. The reaction proceeded via an in situ dehydrative cross-coupling process by taking advantag...

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Bibliographic Details
Main Authors: Liu, Yanan, Xie, Peizhong, Sun, Zuolian, Wo, Xiangyang, Gao, Cuiqing, Fu, Weishan, Loh, Teck-Peng
Other Authors: School of Physical and Mathematical Sciences
Format: Journal Article
Language:English
Published: 2020
Subjects:
Science::Chemistry
Sulfones
Alcohols
Online Access:https://hdl.handle.net/10356/138673
Description
Summary:An environmentally benign protocol that affords propargylic sulfones containing highly congested carbon centers from easily accessible alcohols and sulfinic acids with water as the only byproduct is reported. The reaction proceeded via an in situ dehydrative cross-coupling process by taking advantage of the synergetic actions of multiple hydrogen bonds rather than relying on an external catalyst and/or additives to achieve high product distribution.

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