Graded control of climbing-fiber-mediated plasticity and learning by inhibition in the cerebellum
Purkinje cell dendrites convert excitatory climbing fiber input into signals that instruct plasticity and motor learning. Modulation of instructive signaling may increase the range in which learning is encoded, yet the mechanisms that allow for this are poorly understood. We found that optogenetic a...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Sprog: | English |
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2020
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| Online adgang: | https://hdl.handle.net/10356/138808 |
| _version_ | 1826117331378503680 |
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| author | Rowan, Matthew J. M. Bonnan, Audrey Zhang, Ke Amat, Samantha B. Kikuchi, Chikako Taniguchi, Hiroki Augustine, George James Christie, Jason M. |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Rowan, Matthew J. M. Bonnan, Audrey Zhang, Ke Amat, Samantha B. Kikuchi, Chikako Taniguchi, Hiroki Augustine, George James Christie, Jason M. |
| author_sort | Rowan, Matthew J. M. |
| collection | NTU |
| description | Purkinje cell dendrites convert excitatory climbing fiber input into signals that instruct plasticity and motor learning. Modulation of instructive signaling may increase the range in which learning is encoded, yet the mechanisms that allow for this are poorly understood. We found that optogenetic activation of molecular layer interneurons (MLIs) that inhibit Purkinje cells suppressed climbing-fiber-evoked dendritic Ca2+ spiking. Inhibitory suppression of Ca2+ spiking depended on the level of MLI activation and influenced the induction of associative synaptic plasticity, converting climbing-fiber-mediated potentiation of parallel fiber-evoked responses into depression. In awake mice, optogenetic activation of floccular climbing fibers in association with head rotation produced an adaptive increase in the vestibulo-ocular reflex (VOR). However, when climbing fibers were co-activated with MLIs, adaptation occurred in the opposite direction, decreasing the VOR. Thus, MLIs can direct a continuous spectrum of plasticity and learning through their influence on Purkinje cell dendritic Ca2+ signaling. |
| first_indexed | 2024-10-01T04:25:52Z |
| format | Journal Article |
| id | ntu-10356/138808 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:25:52Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1388082020-05-13T02:09:07Z Graded control of climbing-fiber-mediated plasticity and learning by inhibition in the cerebellum Rowan, Matthew J. M. Bonnan, Audrey Zhang, Ke Amat, Samantha B. Kikuchi, Chikako Taniguchi, Hiroki Augustine, George James Christie, Jason M. Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Cerebellum Climbing Fibers Purkinje cell dendrites convert excitatory climbing fiber input into signals that instruct plasticity and motor learning. Modulation of instructive signaling may increase the range in which learning is encoded, yet the mechanisms that allow for this are poorly understood. We found that optogenetic activation of molecular layer interneurons (MLIs) that inhibit Purkinje cells suppressed climbing-fiber-evoked dendritic Ca2+ spiking. Inhibitory suppression of Ca2+ spiking depended on the level of MLI activation and influenced the induction of associative synaptic plasticity, converting climbing-fiber-mediated potentiation of parallel fiber-evoked responses into depression. In awake mice, optogenetic activation of floccular climbing fibers in association with head rotation produced an adaptive increase in the vestibulo-ocular reflex (VOR). However, when climbing fibers were co-activated with MLIs, adaptation occurred in the opposite direction, decreasing the VOR. Thus, MLIs can direct a continuous spectrum of plasticity and learning through their influence on Purkinje cell dendritic Ca2+ signaling. MOE (Min. of Education, S’pore) 2020-05-13T02:09:07Z 2020-05-13T02:09:07Z 2018 Journal Article Rowan, M. J. M., Bonnan, A., Zhang, K., Amat, S. B., Kikuchi, C., Taniguchi, H., . . . Christie, J. M. (2018). Graded control of climbing-fiber-mediated plasticity and learning by inhibition in the cerebellum. Neuron, 99(5), 999-1015. doi:10.1016/j.neuron.2018.07.024 0896-6273 https://hdl.handle.net/10356/138808 10.1016/j.neuron.2018.07.024 30122378 2-s2.0-85055080407 5 99 999 1015 en Neuron © 2018 Elsevier Inc. All rights reserved. |
| spellingShingle | Science::Medicine Cerebellum Climbing Fibers Rowan, Matthew J. M. Bonnan, Audrey Zhang, Ke Amat, Samantha B. Kikuchi, Chikako Taniguchi, Hiroki Augustine, George James Christie, Jason M. Graded control of climbing-fiber-mediated plasticity and learning by inhibition in the cerebellum |
| title | Graded control of climbing-fiber-mediated plasticity and learning by inhibition in the cerebellum |
| title_full | Graded control of climbing-fiber-mediated plasticity and learning by inhibition in the cerebellum |
| title_fullStr | Graded control of climbing-fiber-mediated plasticity and learning by inhibition in the cerebellum |
| title_full_unstemmed | Graded control of climbing-fiber-mediated plasticity and learning by inhibition in the cerebellum |
| title_short | Graded control of climbing-fiber-mediated plasticity and learning by inhibition in the cerebellum |
| title_sort | graded control of climbing fiber mediated plasticity and learning by inhibition in the cerebellum |
| topic | Science::Medicine Cerebellum Climbing Fibers |
| url | https://hdl.handle.net/10356/138808 |
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