Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressu...

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Main Authors:	Evangelou, Evangelos, Warren, Helen R., Mosen-Ansorena, David, Mifsud, Borbala, Pazoki, Raha, Gao, He, Ntritsos, Georgios, Dimou, Niki, Cabrera, Claudia P., Ibrahim Karaman, Ng, Fu Liang, Evangelou, Marina, Witkowska, Katarzyna, Tzanis, Evan, Hellwege, Jacklyn N., Giri, Ayush, Edwards, Digna R. Velez, Sun, Yan V., Cho, Kelly, Gaziano, J. Michael, Wilson, Peter W. F., Tsao, Philip S., Kovesdy, Csaba P., Esko, Tonu, Mägi, Reedik, Milani, Lili, Almgren, Peter, Boutin, Thibaud, Debette, Stéphanie, Ding, Jun, Giulianini, Franco, Holliday, Elizabeth G., Jackson, Anne U., Li-Gao, Ruifang, Lin, Wei-Yu, Luan, Jian'an, Mangino, Massimo, Oldmeadow, Christopher, Prins, Bram Peter, Qian, Yong, Sargurupremraj, Muralidharan, Shah, Nabi, Surendran, Praveen, Thériault, Sébastien, Verweij, Niek, Willems, Sara M., Zhao, Jing-Hua, Amouyel, Philippe, Connell, John, de Mutsert, Renée, Doney, Alex S. F., Farrall, Martin, Menni, Cristina, Morris, Andrew D., Raymond Noordam, Paré, Guillaume, Poulter, Neil R., Shields, Denis C., Stanton, Alice, Thom, Simon, Abecasis, Gonçalo, Najaf Amin, Arking, Dan E., Ayers, Kristin L., Barbieri, Caterina M., Batini, Chiara, Bis, Joshua C. M., Blake, Tineka, Bochud, Murielle, Boehnke, Michael, Boerwinkle, Eric, Boomsma, Dorret I., Bottinger, Erwin P., Braund, Peter S., Brumat, Marco, Campbell, Archie, Campbell, Harry, Chakravarti, Aravinda, Chambers, John Campbell, Chauhan, Ganesh, Ciullo, Marina, Cocca, Massimiliano, Collins, Francis, Cordell, Heather J., Davies, Gail, de Borst, Martin H., de Geus, Eco J., Deary, Ian J., Deelen, Joris, Del Greco M., Fabiola, Demirkale, Cumhur Yusuf, Dörr, Marcus, Ehret, Georg B., Elosua, Roberto, Enroth, Stefan, Erzurumluoglu, A. Mesut, Ferreira, Teresa, Frånberg, Mattias, Franco, Oscar H., Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Goel, Anuj, Gow, Alan J., Gudnason, Vilmundur, Guo, Xiuqing, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B., Harris, Sarah E., Hartman, Catharina A., Havulinna, Aki S., Hicks, Andrew A., Hofer, Edith, Hofman, Albert, Hottenga, Jouke-Jan, Huffman, Jennifer E., Hwang, Shih-Jen, Ingelsson, Erik, James, Alan, Jansen, Rick, Jarvelin, Marjo-Riitta, Joehanes, Roby, Johansson, Åsa, Johnson, Andrew D., Joshi, Peter K., Jousilahti, Pekka, Jukema, J. Wouter, Jula, Antti, Kähönen, Mika, Kathiresan, Sekar, Keavney, Bernard D., Khaw, Kay-Tee, Knekt, Paul, Knight, Joanne, Kolcic, Ivana, Kooner, Jaspal S., Koskinen, Seppo, Kristiansson, Kati, Kutalik, Zoltan, Laan, Maris, Larson, Marty, Launer, Lenore J., Lehne, Benjamin, Lehtimäki, Terho, Liewald, David C. M., Lin, Li, Lind, Lars, Lindgren, Cecilia M., Liu, YongMei, Loos, Ruth J. F., Lopez, Lorna M., Lu, Yingchang, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Mamasoula, Chrysovalanto, Marrugat, Jaume, Marten, Jonathan, Milaneschi, Yuri, Morgan, Anna, Morris, Andrew P., Morrison, Alanna C., Munson, Peter J., Nalls, Mike A., Nandakumar, Priyanka, Nelson, Christopher P., Niiranen, Teemu, Nolte, Ilja M., Nutile, Teresa, Oldehinkel, Albertine J., Oostra, Ben A., O'Reilly, Paul F., Org, Elin, Padmanabhan, Sandosh, Palmas, Walter, Palotie, Aarno, Pattie, Alison, Penninx, Brenda W. J. H., Perola, Markus, Peters, Annette, Polasek, Ozren, Pramstaller, Peter P., Nguyen, Quang Tri, Raitakari, Olli T., Ren, Meixia, Rettig, Rainer, Rice, Kenneth, Ridker, Paul M., Ried, Janina S., Riese, Harriëtte, Ripatti, Samuli, Robino, Antonietta, Rose, Lynda M., Rotter, Jerome I., Rudan, Igor, Ruggiero, Daniela, Saba, Yasaman, Sala, Cinzia F., Salomaa, Veikko, Samani, Nilesh J., Sarin, Antti-Pekka, Schmidt, Reinhold, Schmidt, Helena, Shrine, Nick, Siscovick, David, Smith, Albert V., Snieder, Harold, Sõber, Siim, Sorice, Rossella, Starr, John M., Stott, David J., Strachan, David P., Strawbridge, Rona J., Sundström, Johan, Swertz, Morris A., Taylor, Kent D., Teumer, Alexander, Tobin, Martin D., Tomaszewski, Maciej, Toniolo, Daniela, Traglia, Michela, Trompet, Stella, Tuomilehto, Jaakko, Tzourio, Christophe, Uitterlinden, André G., Vaez, Ahmad, van der Most, Peter J., van Duijn, Cornelia M., Vergnaud, Anne-Claire, Verwoert, Germaine C., Vitart, Veronique, Völker, Uwe, Vollenweider, Peter, Vuckovic, Dragana, Watkins, Hugh, Wild, Sarah H., Willemsen, Gonneke, Wilson, James F., Wright, Alan F., Yao, Jie, Zemunik, Tatijana, Zhang, Weihua, Attia, John R., Butterworth, Adam S., Chasman, Daniel I., Conen, David, Cucca, Francesco, Danesh, John, Hayward, Caroline, Howson, Joanna M. M., Laakso, Markku, Lakatta, Edward G., Langenberg, Claudia, Melander, Olle, Mook-Kanamori, Dennis O., Palmer, Colin N. A., Risch, Lorenz, Scott, Robert A., Scott, Rodney J., Sever, Peter, Spector, Tim D., van der Harst, Pim, Wareham, Nicholas J., Zeggini, Eleftheria, Levy, Daniel, Munroe, Patricia B., Newton-Cheh, Christopher, Brown, Morris J., Metspalu, Andres, Hung, Adriana M., O'Donnell, Christopher J., Edwards, Todd L., Psaty, Bruce M., Tzoulaki, Ioanna, Barnes, Michael R., Wain, Louise V., Elliott, Paul, Caulfield, Mark J.
Other Authors:	Lee Kong Chian School of Medicine (LKCMedicine)
Format:	Journal Article
Language:	English
Published:	2020
Subjects:	Science::Medicine Cardiovascular Diseases Genome Informatics
Online Access:	https://hdl.handle.net/10356/138835

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author	Evangelou, Evangelos Warren, Helen R. Mosen-Ansorena, David Mifsud, Borbala Pazoki, Raha Gao, He Ntritsos, Georgios Dimou, Niki Cabrera, Claudia P. Ibrahim Karaman Ng, Fu Liang Evangelou, Marina Witkowska, Katarzyna Tzanis, Evan Hellwege, Jacklyn N. Giri, Ayush Edwards, Digna R. Velez Sun, Yan V. Cho, Kelly Gaziano, J. Michael Wilson, Peter W. F. Tsao, Philip S. Kovesdy, Csaba P. Esko, Tonu Mägi, Reedik Milani, Lili Almgren, Peter Boutin, Thibaud Debette, Stéphanie Ding, Jun Giulianini, Franco Holliday, Elizabeth G. Jackson, Anne U. Li-Gao, Ruifang Lin, Wei-Yu Luan, Jian'an Mangino, Massimo Oldmeadow, Christopher Prins, Bram Peter Qian, Yong Sargurupremraj, Muralidharan Shah, Nabi Surendran, Praveen Thériault, Sébastien Verweij, Niek Willems, Sara M. Zhao, Jing-Hua Amouyel, Philippe Connell, John de Mutsert, Renée Doney, Alex S. F. Farrall, Martin Menni, Cristina Morris, Andrew D. Raymond Noordam Paré, Guillaume Poulter, Neil R. Shields, Denis C. Stanton, Alice Thom, Simon Abecasis, Gonçalo Najaf Amin Arking, Dan E. Ayers, Kristin L. Barbieri, Caterina M. Batini, Chiara Bis, Joshua C. M. Blake, Tineka Bochud, Murielle Boehnke, Michael Boerwinkle, Eric Boomsma, Dorret I. Bottinger, Erwin P. Braund, Peter S. Brumat, Marco Campbell, Archie Campbell, Harry Chakravarti, Aravinda Chambers, John Campbell Chauhan, Ganesh Ciullo, Marina Cocca, Massimiliano Collins, Francis Cordell, Heather J. Davies, Gail de Borst, Martin H. de Geus, Eco J. Deary, Ian J. Deelen, Joris Del Greco M., Fabiola Demirkale, Cumhur Yusuf Dörr, Marcus Ehret, Georg B. Elosua, Roberto Enroth, Stefan Erzurumluoglu, A. Mesut Ferreira, Teresa Frånberg, Mattias Franco, Oscar H. Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Gieger, Christian Girotto, Giorgia Goel, Anuj Gow, Alan J. Gudnason, Vilmundur Guo, Xiuqing Gyllensten, Ulf Hamsten, Anders Harris, Tamara B. Harris, Sarah E. Hartman, Catharina A. Havulinna, Aki S. Hicks, Andrew A. Hofer, Edith Hofman, Albert Hottenga, Jouke-Jan Huffman, Jennifer E. Hwang, Shih-Jen Ingelsson, Erik James, Alan Jansen, Rick Jarvelin, Marjo-Riitta Joehanes, Roby Johansson, Åsa Johnson, Andrew D. Joshi, Peter K. Jousilahti, Pekka Jukema, J. Wouter Jula, Antti Kähönen, Mika Kathiresan, Sekar Keavney, Bernard D. Khaw, Kay-Tee Knekt, Paul Knight, Joanne Kolcic, Ivana Kooner, Jaspal S. Koskinen, Seppo Kristiansson, Kati Kutalik, Zoltan Laan, Maris Larson, Marty Launer, Lenore J. Lehne, Benjamin Lehtimäki, Terho Liewald, David C. M. Lin, Li Lind, Lars Lindgren, Cecilia M. Liu, YongMei Loos, Ruth J. F. Lopez, Lorna M. Lu, Yingchang Lyytikäinen, Leo-Pekka Mahajan, Anubha Mamasoula, Chrysovalanto Marrugat, Jaume Marten, Jonathan Milaneschi, Yuri Morgan, Anna Morris, Andrew P. Morrison, Alanna C. Munson, Peter J. Nalls, Mike A. Nandakumar, Priyanka Nelson, Christopher P. Niiranen, Teemu Nolte, Ilja M. Nutile, Teresa Oldehinkel, Albertine J. Oostra, Ben A. O'Reilly, Paul F. Org, Elin Padmanabhan, Sandosh Palmas, Walter Palotie, Aarno Pattie, Alison Penninx, Brenda W. J. H. Perola, Markus Peters, Annette Polasek, Ozren Pramstaller, Peter P. Nguyen, Quang Tri Raitakari, Olli T. Ren, Meixia Rettig, Rainer Rice, Kenneth Ridker, Paul M. Ried, Janina S. Riese, Harriëtte Ripatti, Samuli Robino, Antonietta Rose, Lynda M. Rotter, Jerome I. Rudan, Igor Ruggiero, Daniela Saba, Yasaman Sala, Cinzia F. Salomaa, Veikko Samani, Nilesh J. Sarin, Antti-Pekka Schmidt, Reinhold Schmidt, Helena Shrine, Nick Siscovick, David Smith, Albert V. Snieder, Harold Sõber, Siim Sorice, Rossella Starr, John M. Stott, David J. Strachan, David P. Strawbridge, Rona J. Sundström, Johan Swertz, Morris A. Taylor, Kent D. Teumer, Alexander Tobin, Martin D. Tomaszewski, Maciej Toniolo, Daniela Traglia, Michela Trompet, Stella Tuomilehto, Jaakko Tzourio, Christophe Uitterlinden, André G. Vaez, Ahmad van der Most, Peter J. van Duijn, Cornelia M. Vergnaud, Anne-Claire Verwoert, Germaine C. Vitart, Veronique Völker, Uwe Vollenweider, Peter Vuckovic, Dragana Watkins, Hugh Wild, Sarah H. Willemsen, Gonneke Wilson, James F. Wright, Alan F. Yao, Jie Zemunik, Tatijana Zhang, Weihua Attia, John R. Butterworth, Adam S. Chasman, Daniel I. Conen, David Cucca, Francesco Danesh, John Hayward, Caroline Howson, Joanna M. M. Laakso, Markku Lakatta, Edward G. Langenberg, Claudia Melander, Olle Mook-Kanamori, Dennis O. Palmer, Colin N. A. Risch, Lorenz Scott, Robert A. Scott, Rodney J. Sever, Peter Spector, Tim D. van der Harst, Pim Wareham, Nicholas J. Zeggini, Eleftheria Levy, Daniel Munroe, Patricia B. Newton-Cheh, Christopher Brown, Morris J. Metspalu, Andres Hung, Adriana M. O'Donnell, Christopher J. Edwards, Todd L. Psaty, Bruce M. Tzoulaki, Ioanna Barnes, Michael R. Wain, Louise V. Elliott, Paul Caulfield, Mark J.
author2	Lee Kong Chian School of Medicine (LKCMedicine)
author_facet	Lee Kong Chian School of Medicine (LKCMedicine) Evangelou, Evangelos Warren, Helen R. Mosen-Ansorena, David Mifsud, Borbala Pazoki, Raha Gao, He Ntritsos, Georgios Dimou, Niki Cabrera, Claudia P. Ibrahim Karaman Ng, Fu Liang Evangelou, Marina Witkowska, Katarzyna Tzanis, Evan Hellwege, Jacklyn N. Giri, Ayush Edwards, Digna R. Velez Sun, Yan V. Cho, Kelly Gaziano, J. Michael Wilson, Peter W. F. Tsao, Philip S. Kovesdy, Csaba P. Esko, Tonu Mägi, Reedik Milani, Lili Almgren, Peter Boutin, Thibaud Debette, Stéphanie Ding, Jun Giulianini, Franco Holliday, Elizabeth G. Jackson, Anne U. Li-Gao, Ruifang Lin, Wei-Yu Luan, Jian'an Mangino, Massimo Oldmeadow, Christopher Prins, Bram Peter Qian, Yong Sargurupremraj, Muralidharan Shah, Nabi Surendran, Praveen Thériault, Sébastien Verweij, Niek Willems, Sara M. Zhao, Jing-Hua Amouyel, Philippe Connell, John de Mutsert, Renée Doney, Alex S. F. Farrall, Martin Menni, Cristina Morris, Andrew D. Raymond Noordam Paré, Guillaume Poulter, Neil R. Shields, Denis C. Stanton, Alice Thom, Simon Abecasis, Gonçalo Najaf Amin Arking, Dan E. Ayers, Kristin L. Barbieri, Caterina M. Batini, Chiara Bis, Joshua C. M. Blake, Tineka Bochud, Murielle Boehnke, Michael Boerwinkle, Eric Boomsma, Dorret I. Bottinger, Erwin P. Braund, Peter S. Brumat, Marco Campbell, Archie Campbell, Harry Chakravarti, Aravinda Chambers, John Campbell Chauhan, Ganesh Ciullo, Marina Cocca, Massimiliano Collins, Francis Cordell, Heather J. Davies, Gail de Borst, Martin H. de Geus, Eco J. Deary, Ian J. Deelen, Joris Del Greco M., Fabiola Demirkale, Cumhur Yusuf Dörr, Marcus Ehret, Georg B. Elosua, Roberto Enroth, Stefan Erzurumluoglu, A. Mesut Ferreira, Teresa Frånberg, Mattias Franco, Oscar H. Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Gieger, Christian Girotto, Giorgia Goel, Anuj Gow, Alan J. Gudnason, Vilmundur Guo, Xiuqing Gyllensten, Ulf Hamsten, Anders Harris, Tamara B. Harris, Sarah E. Hartman, Catharina A. Havulinna, Aki S. Hicks, Andrew A. Hofer, Edith Hofman, Albert Hottenga, Jouke-Jan Huffman, Jennifer E. Hwang, Shih-Jen Ingelsson, Erik James, Alan Jansen, Rick Jarvelin, Marjo-Riitta Joehanes, Roby Johansson, Åsa Johnson, Andrew D. Joshi, Peter K. Jousilahti, Pekka Jukema, J. Wouter Jula, Antti Kähönen, Mika Kathiresan, Sekar Keavney, Bernard D. Khaw, Kay-Tee Knekt, Paul Knight, Joanne Kolcic, Ivana Kooner, Jaspal S. Koskinen, Seppo Kristiansson, Kati Kutalik, Zoltan Laan, Maris Larson, Marty Launer, Lenore J. Lehne, Benjamin Lehtimäki, Terho Liewald, David C. M. Lin, Li Lind, Lars Lindgren, Cecilia M. Liu, YongMei Loos, Ruth J. F. Lopez, Lorna M. Lu, Yingchang Lyytikäinen, Leo-Pekka Mahajan, Anubha Mamasoula, Chrysovalanto Marrugat, Jaume Marten, Jonathan Milaneschi, Yuri Morgan, Anna Morris, Andrew P. Morrison, Alanna C. Munson, Peter J. Nalls, Mike A. Nandakumar, Priyanka Nelson, Christopher P. Niiranen, Teemu Nolte, Ilja M. Nutile, Teresa Oldehinkel, Albertine J. Oostra, Ben A. O'Reilly, Paul F. Org, Elin Padmanabhan, Sandosh Palmas, Walter Palotie, Aarno Pattie, Alison Penninx, Brenda W. J. H. Perola, Markus Peters, Annette Polasek, Ozren Pramstaller, Peter P. Nguyen, Quang Tri Raitakari, Olli T. Ren, Meixia Rettig, Rainer Rice, Kenneth Ridker, Paul M. Ried, Janina S. Riese, Harriëtte Ripatti, Samuli Robino, Antonietta Rose, Lynda M. Rotter, Jerome I. Rudan, Igor Ruggiero, Daniela Saba, Yasaman Sala, Cinzia F. Salomaa, Veikko Samani, Nilesh J. Sarin, Antti-Pekka Schmidt, Reinhold Schmidt, Helena Shrine, Nick Siscovick, David Smith, Albert V. Snieder, Harold Sõber, Siim Sorice, Rossella Starr, John M. Stott, David J. Strachan, David P. Strawbridge, Rona J. Sundström, Johan Swertz, Morris A. Taylor, Kent D. Teumer, Alexander Tobin, Martin D. Tomaszewski, Maciej Toniolo, Daniela Traglia, Michela Trompet, Stella Tuomilehto, Jaakko Tzourio, Christophe Uitterlinden, André G. Vaez, Ahmad van der Most, Peter J. van Duijn, Cornelia M. Vergnaud, Anne-Claire Verwoert, Germaine C. Vitart, Veronique Völker, Uwe Vollenweider, Peter Vuckovic, Dragana Watkins, Hugh Wild, Sarah H. Willemsen, Gonneke Wilson, James F. Wright, Alan F. Yao, Jie Zemunik, Tatijana Zhang, Weihua Attia, John R. Butterworth, Adam S. Chasman, Daniel I. Conen, David Cucca, Francesco Danesh, John Hayward, Caroline Howson, Joanna M. M. Laakso, Markku Lakatta, Edward G. Langenberg, Claudia Melander, Olle Mook-Kanamori, Dennis O. Palmer, Colin N. A. Risch, Lorenz Scott, Robert A. Scott, Rodney J. Sever, Peter Spector, Tim D. van der Harst, Pim Wareham, Nicholas J. Zeggini, Eleftheria Levy, Daniel Munroe, Patricia B. Newton-Cheh, Christopher Brown, Morris J. Metspalu, Andres Hung, Adriana M. O'Donnell, Christopher J. Edwards, Todd L. Psaty, Bruce M. Tzoulaki, Ioanna Barnes, Michael R. Wain, Louise V. Elliott, Paul Caulfield, Mark J.
author_sort	Evangelou, Evangelos
collection	NTU
description	High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
first_indexed	2025-02-19T03:42:15Z
format	Journal Article
id	ntu-10356/138835
institution	Nanyang Technological University
language	English
last_indexed	2025-02-19T03:42:15Z
publishDate	2020
record_format	dspace
spelling	ntu-10356/1388352020-05-13T05:04:34Z Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits Evangelou, Evangelos Warren, Helen R. Mosen-Ansorena, David Mifsud, Borbala Pazoki, Raha Gao, He Ntritsos, Georgios Dimou, Niki Cabrera, Claudia P. Ibrahim Karaman Ng, Fu Liang Evangelou, Marina Witkowska, Katarzyna Tzanis, Evan Hellwege, Jacklyn N. Giri, Ayush Edwards, Digna R. Velez Sun, Yan V. Cho, Kelly Gaziano, J. Michael Wilson, Peter W. F. Tsao, Philip S. Kovesdy, Csaba P. Esko, Tonu Mägi, Reedik Milani, Lili Almgren, Peter Boutin, Thibaud Debette, Stéphanie Ding, Jun Giulianini, Franco Holliday, Elizabeth G. Jackson, Anne U. Li-Gao, Ruifang Lin, Wei-Yu Luan, Jian'an Mangino, Massimo Oldmeadow, Christopher Prins, Bram Peter Qian, Yong Sargurupremraj, Muralidharan Shah, Nabi Surendran, Praveen Thériault, Sébastien Verweij, Niek Willems, Sara M. Zhao, Jing-Hua Amouyel, Philippe Connell, John de Mutsert, Renée Doney, Alex S. F. Farrall, Martin Menni, Cristina Morris, Andrew D. Raymond Noordam Paré, Guillaume Poulter, Neil R. Shields, Denis C. Stanton, Alice Thom, Simon Abecasis, Gonçalo Najaf Amin Arking, Dan E. Ayers, Kristin L. Barbieri, Caterina M. Batini, Chiara Bis, Joshua C. M. Blake, Tineka Bochud, Murielle Boehnke, Michael Boerwinkle, Eric Boomsma, Dorret I. Bottinger, Erwin P. Braund, Peter S. Brumat, Marco Campbell, Archie Campbell, Harry Chakravarti, Aravinda Chambers, John Campbell Chauhan, Ganesh Ciullo, Marina Cocca, Massimiliano Collins, Francis Cordell, Heather J. Davies, Gail de Borst, Martin H. de Geus, Eco J. Deary, Ian J. Deelen, Joris Del Greco M., Fabiola Demirkale, Cumhur Yusuf Dörr, Marcus Ehret, Georg B. Elosua, Roberto Enroth, Stefan Erzurumluoglu, A. Mesut Ferreira, Teresa Frånberg, Mattias Franco, Oscar H. Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Gieger, Christian Girotto, Giorgia Goel, Anuj Gow, Alan J. Gudnason, Vilmundur Guo, Xiuqing Gyllensten, Ulf Hamsten, Anders Harris, Tamara B. Harris, Sarah E. Hartman, Catharina A. Havulinna, Aki S. Hicks, Andrew A. Hofer, Edith Hofman, Albert Hottenga, Jouke-Jan Huffman, Jennifer E. Hwang, Shih-Jen Ingelsson, Erik James, Alan Jansen, Rick Jarvelin, Marjo-Riitta Joehanes, Roby Johansson, Åsa Johnson, Andrew D. Joshi, Peter K. Jousilahti, Pekka Jukema, J. Wouter Jula, Antti Kähönen, Mika Kathiresan, Sekar Keavney, Bernard D. Khaw, Kay-Tee Knekt, Paul Knight, Joanne Kolcic, Ivana Kooner, Jaspal S. Koskinen, Seppo Kristiansson, Kati Kutalik, Zoltan Laan, Maris Larson, Marty Launer, Lenore J. Lehne, Benjamin Lehtimäki, Terho Liewald, David C. M. Lin, Li Lind, Lars Lindgren, Cecilia M. Liu, YongMei Loos, Ruth J. F. Lopez, Lorna M. Lu, Yingchang Lyytikäinen, Leo-Pekka Mahajan, Anubha Mamasoula, Chrysovalanto Marrugat, Jaume Marten, Jonathan Milaneschi, Yuri Morgan, Anna Morris, Andrew P. Morrison, Alanna C. Munson, Peter J. Nalls, Mike A. Nandakumar, Priyanka Nelson, Christopher P. Niiranen, Teemu Nolte, Ilja M. Nutile, Teresa Oldehinkel, Albertine J. Oostra, Ben A. O'Reilly, Paul F. Org, Elin Padmanabhan, Sandosh Palmas, Walter Palotie, Aarno Pattie, Alison Penninx, Brenda W. J. H. Perola, Markus Peters, Annette Polasek, Ozren Pramstaller, Peter P. Nguyen, Quang Tri Raitakari, Olli T. Ren, Meixia Rettig, Rainer Rice, Kenneth Ridker, Paul M. Ried, Janina S. Riese, Harriëtte Ripatti, Samuli Robino, Antonietta Rose, Lynda M. Rotter, Jerome I. Rudan, Igor Ruggiero, Daniela Saba, Yasaman Sala, Cinzia F. Salomaa, Veikko Samani, Nilesh J. Sarin, Antti-Pekka Schmidt, Reinhold Schmidt, Helena Shrine, Nick Siscovick, David Smith, Albert V. Snieder, Harold Sõber, Siim Sorice, Rossella Starr, John M. Stott, David J. Strachan, David P. Strawbridge, Rona J. Sundström, Johan Swertz, Morris A. Taylor, Kent D. Teumer, Alexander Tobin, Martin D. Tomaszewski, Maciej Toniolo, Daniela Traglia, Michela Trompet, Stella Tuomilehto, Jaakko Tzourio, Christophe Uitterlinden, André G. Vaez, Ahmad van der Most, Peter J. van Duijn, Cornelia M. Vergnaud, Anne-Claire Verwoert, Germaine C. Vitart, Veronique Völker, Uwe Vollenweider, Peter Vuckovic, Dragana Watkins, Hugh Wild, Sarah H. Willemsen, Gonneke Wilson, James F. Wright, Alan F. Yao, Jie Zemunik, Tatijana Zhang, Weihua Attia, John R. Butterworth, Adam S. Chasman, Daniel I. Conen, David Cucca, Francesco Danesh, John Hayward, Caroline Howson, Joanna M. M. Laakso, Markku Lakatta, Edward G. Langenberg, Claudia Melander, Olle Mook-Kanamori, Dennis O. Palmer, Colin N. A. Risch, Lorenz Scott, Robert A. Scott, Rodney J. Sever, Peter Spector, Tim D. van der Harst, Pim Wareham, Nicholas J. Zeggini, Eleftheria Levy, Daniel Munroe, Patricia B. Newton-Cheh, Christopher Brown, Morris J. Metspalu, Andres Hung, Adriana M. O'Donnell, Christopher J. Edwards, Todd L. Psaty, Bruce M. Tzoulaki, Ioanna Barnes, Michael R. Wain, Louise V. Elliott, Paul Caulfield, Mark J. Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Cardiovascular Diseases Genome Informatics High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. NMRC (Natl Medical Research Council, S’pore) MOH (Min. of Health, S’pore) 2020-05-13T05:04:33Z 2020-05-13T05:04:33Z 2018 Journal Article Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., . . . Caulfield, M. J. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50(10), 1412-1425. doi:10.1038/s41588-018-0205-x 1061-4036 https://hdl.handle.net/10356/138835 10.1038/s41588-018-0205-x 30224653 2-s2.0-85053701561 10 50 1412 1425 en Nature Genetics © 2018 The Author(s) (Nature Publishing Group). All rights reserved.
spellingShingle	Science::Medicine Cardiovascular Diseases Genome Informatics Evangelou, Evangelos Warren, Helen R. Mosen-Ansorena, David Mifsud, Borbala Pazoki, Raha Gao, He Ntritsos, Georgios Dimou, Niki Cabrera, Claudia P. Ibrahim Karaman Ng, Fu Liang Evangelou, Marina Witkowska, Katarzyna Tzanis, Evan Hellwege, Jacklyn N. Giri, Ayush Edwards, Digna R. Velez Sun, Yan V. Cho, Kelly Gaziano, J. Michael Wilson, Peter W. F. Tsao, Philip S. Kovesdy, Csaba P. Esko, Tonu Mägi, Reedik Milani, Lili Almgren, Peter Boutin, Thibaud Debette, Stéphanie Ding, Jun Giulianini, Franco Holliday, Elizabeth G. Jackson, Anne U. Li-Gao, Ruifang Lin, Wei-Yu Luan, Jian'an Mangino, Massimo Oldmeadow, Christopher Prins, Bram Peter Qian, Yong Sargurupremraj, Muralidharan Shah, Nabi Surendran, Praveen Thériault, Sébastien Verweij, Niek Willems, Sara M. Zhao, Jing-Hua Amouyel, Philippe Connell, John de Mutsert, Renée Doney, Alex S. F. Farrall, Martin Menni, Cristina Morris, Andrew D. Raymond Noordam Paré, Guillaume Poulter, Neil R. Shields, Denis C. Stanton, Alice Thom, Simon Abecasis, Gonçalo Najaf Amin Arking, Dan E. Ayers, Kristin L. Barbieri, Caterina M. Batini, Chiara Bis, Joshua C. M. Blake, Tineka Bochud, Murielle Boehnke, Michael Boerwinkle, Eric Boomsma, Dorret I. Bottinger, Erwin P. Braund, Peter S. Brumat, Marco Campbell, Archie Campbell, Harry Chakravarti, Aravinda Chambers, John Campbell Chauhan, Ganesh Ciullo, Marina Cocca, Massimiliano Collins, Francis Cordell, Heather J. Davies, Gail de Borst, Martin H. de Geus, Eco J. Deary, Ian J. Deelen, Joris Del Greco M., Fabiola Demirkale, Cumhur Yusuf Dörr, Marcus Ehret, Georg B. Elosua, Roberto Enroth, Stefan Erzurumluoglu, A. Mesut Ferreira, Teresa Frånberg, Mattias Franco, Oscar H. Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Gieger, Christian Girotto, Giorgia Goel, Anuj Gow, Alan J. Gudnason, Vilmundur Guo, Xiuqing Gyllensten, Ulf Hamsten, Anders Harris, Tamara B. Harris, Sarah E. Hartman, Catharina A. Havulinna, Aki S. Hicks, Andrew A. Hofer, Edith Hofman, Albert Hottenga, Jouke-Jan Huffman, Jennifer E. Hwang, Shih-Jen Ingelsson, Erik James, Alan Jansen, Rick Jarvelin, Marjo-Riitta Joehanes, Roby Johansson, Åsa Johnson, Andrew D. Joshi, Peter K. Jousilahti, Pekka Jukema, J. Wouter Jula, Antti Kähönen, Mika Kathiresan, Sekar Keavney, Bernard D. Khaw, Kay-Tee Knekt, Paul Knight, Joanne Kolcic, Ivana Kooner, Jaspal S. Koskinen, Seppo Kristiansson, Kati Kutalik, Zoltan Laan, Maris Larson, Marty Launer, Lenore J. Lehne, Benjamin Lehtimäki, Terho Liewald, David C. M. Lin, Li Lind, Lars Lindgren, Cecilia M. Liu, YongMei Loos, Ruth J. F. Lopez, Lorna M. Lu, Yingchang Lyytikäinen, Leo-Pekka Mahajan, Anubha Mamasoula, Chrysovalanto Marrugat, Jaume Marten, Jonathan Milaneschi, Yuri Morgan, Anna Morris, Andrew P. Morrison, Alanna C. Munson, Peter J. Nalls, Mike A. Nandakumar, Priyanka Nelson, Christopher P. Niiranen, Teemu Nolte, Ilja M. Nutile, Teresa Oldehinkel, Albertine J. Oostra, Ben A. O'Reilly, Paul F. Org, Elin Padmanabhan, Sandosh Palmas, Walter Palotie, Aarno Pattie, Alison Penninx, Brenda W. J. H. Perola, Markus Peters, Annette Polasek, Ozren Pramstaller, Peter P. Nguyen, Quang Tri Raitakari, Olli T. Ren, Meixia Rettig, Rainer Rice, Kenneth Ridker, Paul M. Ried, Janina S. Riese, Harriëtte Ripatti, Samuli Robino, Antonietta Rose, Lynda M. Rotter, Jerome I. Rudan, Igor Ruggiero, Daniela Saba, Yasaman Sala, Cinzia F. Salomaa, Veikko Samani, Nilesh J. Sarin, Antti-Pekka Schmidt, Reinhold Schmidt, Helena Shrine, Nick Siscovick, David Smith, Albert V. Snieder, Harold Sõber, Siim Sorice, Rossella Starr, John M. Stott, David J. Strachan, David P. Strawbridge, Rona J. Sundström, Johan Swertz, Morris A. Taylor, Kent D. Teumer, Alexander Tobin, Martin D. Tomaszewski, Maciej Toniolo, Daniela Traglia, Michela Trompet, Stella Tuomilehto, Jaakko Tzourio, Christophe Uitterlinden, André G. Vaez, Ahmad van der Most, Peter J. van Duijn, Cornelia M. Vergnaud, Anne-Claire Verwoert, Germaine C. Vitart, Veronique Völker, Uwe Vollenweider, Peter Vuckovic, Dragana Watkins, Hugh Wild, Sarah H. Willemsen, Gonneke Wilson, James F. Wright, Alan F. Yao, Jie Zemunik, Tatijana Zhang, Weihua Attia, John R. Butterworth, Adam S. Chasman, Daniel I. Conen, David Cucca, Francesco Danesh, John Hayward, Caroline Howson, Joanna M. M. Laakso, Markku Lakatta, Edward G. Langenberg, Claudia Melander, Olle Mook-Kanamori, Dennis O. Palmer, Colin N. A. Risch, Lorenz Scott, Robert A. Scott, Rodney J. Sever, Peter Spector, Tim D. van der Harst, Pim Wareham, Nicholas J. Zeggini, Eleftheria Levy, Daniel Munroe, Patricia B. Newton-Cheh, Christopher Brown, Morris J. Metspalu, Andres Hung, Adriana M. O'Donnell, Christopher J. Edwards, Todd L. Psaty, Bruce M. Tzoulaki, Ioanna Barnes, Michael R. Wain, Louise V. Elliott, Paul Caulfield, Mark J. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
title	Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
title_full	Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
title_fullStr	Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
title_full_unstemmed	Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
title_short	Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
title_sort	genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
topic	Science::Medicine Cardiovascular Diseases Genome Informatics
url	https://hdl.handle.net/10356/138835
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geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT vuckovicdragana geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT watkinshugh geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT wildsarahh geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT willemsengonneke geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT wilsonjamesf geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT wrightalanf geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT yaojie geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT zemuniktatijana geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT zhangweihua geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT attiajohnr geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT butterworthadams geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT chasmandanieli geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT conendavid geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT cuccafrancesco geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT daneshjohn geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT haywardcaroline geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT howsonjoannamm geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT laaksomarkku geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT lakattaedwardg geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT langenbergclaudia geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT melanderolle geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT mookkanamoridenniso geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT palmercolinna geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT rischlorenz geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT scottroberta geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT scottrodneyj geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT severpeter geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT spectortimd geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT vanderharstpim geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT warehamnicholasj geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT zegginieleftheria geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT levydaniel geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT munroepatriciab geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT newtonchehchristopher geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT brownmorrisj geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT metspaluandres geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT hungadrianam geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT odonnellchristopherj geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT edwardstoddl geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT psatybrucem geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT tzoulakiioanna geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT barnesmichaelr geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT wainlouisev geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT elliottpaul geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits AT caulfieldmarkj geneticanalysisofover1millionpeopleidentifies535newlociassociatedwithbloodpressuretraits

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

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