Understanding the effect of inflammation on the cytotoxicity of inhaled nanoparticles to human lungs epithelial cells
Nanomaterials (NMs) are everywhere around the world, and it has been useful for humans consistently. However, it has also been proved to be harmful to humans as well, particularly in the pulmonary system. Although many studies have been conducted regarding the toxicity of NMs, it only studies the ce...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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Nanyang Technological University
2020
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| Online Access: | https://hdl.handle.net/10356/138840 |
| _version_ | 1811691072712081408 |
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| author | Chailim, Willis |
| author2 | Dalton Tay Chor Yong |
| author_facet | Dalton Tay Chor Yong Chailim, Willis |
| author_sort | Chailim, Willis |
| collection | NTU |
| description | Nanomaterials (NMs) are everywhere around the world, and it has been useful for humans consistently. However, it has also been proved to be harmful to humans as well, particularly in the pulmonary system. Although many studies have been conducted regarding the toxicity of NMs, it only studies the cells that are in healthy condition. At the same time, it is also important to consider people with lung diseases such as pulmonary edema, cystic fibrosis, and chronic obstructive pulmonary diseases that cause inflammation to their cells. Therefore, there is a need to study how inflammation affects the response of cells to NMs in terms of toxicity. Inflamed small airway epithelial cells (SAECs) were shown to have overexpression of protein markers and genes. They also showed to have a high susceptibility to high doses of NMs while healthy SAECs have low susceptibility. This difference happened because of the low level of antioxidants and proteolytic activity that negates the ROS level and mitigates NMs toxicity respectively. All the studies conducted can be support for further studies about nanotoxicology. Furthermore, future work could be conducted in terms of whether lung cells could adapt to NMs or not and compare the difference between healthy cells and inflamed cells. |
| first_indexed | 2024-10-01T06:14:05Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/138840 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:14:05Z |
| publishDate | 2020 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1388402023-03-04T15:47:23Z Understanding the effect of inflammation on the cytotoxicity of inhaled nanoparticles to human lungs epithelial cells Chailim, Willis Dalton Tay Chor Yong School of Materials Science and Engineering cytay@ntu.edu.sg Engineering::Bioengineering Engineering::Nanotechnology Nanomaterials (NMs) are everywhere around the world, and it has been useful for humans consistently. However, it has also been proved to be harmful to humans as well, particularly in the pulmonary system. Although many studies have been conducted regarding the toxicity of NMs, it only studies the cells that are in healthy condition. At the same time, it is also important to consider people with lung diseases such as pulmonary edema, cystic fibrosis, and chronic obstructive pulmonary diseases that cause inflammation to their cells. Therefore, there is a need to study how inflammation affects the response of cells to NMs in terms of toxicity. Inflamed small airway epithelial cells (SAECs) were shown to have overexpression of protein markers and genes. They also showed to have a high susceptibility to high doses of NMs while healthy SAECs have low susceptibility. This difference happened because of the low level of antioxidants and proteolytic activity that negates the ROS level and mitigates NMs toxicity respectively. All the studies conducted can be support for further studies about nanotoxicology. Furthermore, future work could be conducted in terms of whether lung cells could adapt to NMs or not and compare the difference between healthy cells and inflamed cells. Bachelor of Engineering (Materials Engineering) 2020-05-13T05:15:35Z 2020-05-13T05:15:35Z 2020 Final Year Project (FYP) https://hdl.handle.net/10356/138840 en MSE/19/070 application/pdf Nanyang Technological University |
| spellingShingle | Engineering::Bioengineering Engineering::Nanotechnology Chailim, Willis Understanding the effect of inflammation on the cytotoxicity of inhaled nanoparticles to human lungs epithelial cells |
| title | Understanding the effect of inflammation on the cytotoxicity of inhaled nanoparticles to human lungs epithelial cells |
| title_full | Understanding the effect of inflammation on the cytotoxicity of inhaled nanoparticles to human lungs epithelial cells |
| title_fullStr | Understanding the effect of inflammation on the cytotoxicity of inhaled nanoparticles to human lungs epithelial cells |
| title_full_unstemmed | Understanding the effect of inflammation on the cytotoxicity of inhaled nanoparticles to human lungs epithelial cells |
| title_short | Understanding the effect of inflammation on the cytotoxicity of inhaled nanoparticles to human lungs epithelial cells |
| title_sort | understanding the effect of inflammation on the cytotoxicity of inhaled nanoparticles to human lungs epithelial cells |
| topic | Engineering::Bioengineering Engineering::Nanotechnology |
| url | https://hdl.handle.net/10356/138840 |
| work_keys_str_mv | AT chailimwillis understandingtheeffectofinflammationonthecytotoxicityofinhalednanoparticlestohumanlungsepithelialcells |