Highly sensitive, label-free detection of 2,4-dichlorophenoxyacetic acid using an optofluidic chip
A highly sensitive approach for rapid and label-free detection of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) using an optofluidic chip is demonstrated. The optofluidic chip is prepared by covalent immobilization of 2,4-D-bovine serum albumin (2,4-D-BSA) conjugate to an integrated microring...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | https://hdl.handle.net/10356/139094 |
| _version_ | 1826118481041424384 |
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| author | Feng, Xueling Zhang, Gong Chin, Lip Ket Liu, Ai Qun Liedberg, Bo |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Feng, Xueling Zhang, Gong Chin, Lip Ket Liu, Ai Qun Liedberg, Bo |
| author_sort | Feng, Xueling |
| collection | NTU |
| description | A highly sensitive approach for rapid and label-free detection of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) using an optofluidic chip is demonstrated. The optofluidic chip is prepared by covalent immobilization of 2,4-D-bovine serum albumin (2,4-D-BSA) conjugate to an integrated microring resonator. Subsequent detection of 2,4-D carried out in a competitive immunoreaction format enables selective detection of 2,4-D in different types of water samples, including bottled, tap, and lake water, at a limit of detection (LOD) of 4.5 pg/mL and in a quantitative range of 15-105 pg/mL. The microring resonator-based optofluidic chip is reusable with ultrahigh sensitivity that offers real-time and on-site detection of low-molecular-weight targets for potential applications in food safety and environmental monitoring. |
| first_indexed | 2024-10-01T04:44:07Z |
| format | Journal Article |
| id | ntu-10356/139094 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:44:07Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1390942020-06-01T10:13:42Z Highly sensitive, label-free detection of 2,4-dichlorophenoxyacetic acid using an optofluidic chip Feng, Xueling Zhang, Gong Chin, Lip Ket Liu, Ai Qun Liedberg, Bo School of Electrical and Electronic Engineering School of Materials Science & Engineering Centre for Biomimetic Sensor Science Engineering::Electrical and electronic engineering Optofluidic Chip Microring Resonator A highly sensitive approach for rapid and label-free detection of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) using an optofluidic chip is demonstrated. The optofluidic chip is prepared by covalent immobilization of 2,4-D-bovine serum albumin (2,4-D-BSA) conjugate to an integrated microring resonator. Subsequent detection of 2,4-D carried out in a competitive immunoreaction format enables selective detection of 2,4-D in different types of water samples, including bottled, tap, and lake water, at a limit of detection (LOD) of 4.5 pg/mL and in a quantitative range of 15-105 pg/mL. The microring resonator-based optofluidic chip is reusable with ultrahigh sensitivity that offers real-time and on-site detection of low-molecular-weight targets for potential applications in food safety and environmental monitoring. NRF (Natl Research Foundation, S’pore) Accepted version 2020-05-15T06:22:32Z 2020-05-15T06:22:32Z 2017 Journal Article Feng, X., Zhang, G., Chin, L. K., Liu, A. Q., & Liedberg, B. (2017). Highly sensitive, label-free detection of 2,4-dichlorophenoxyacetic acid using an optofluidic chip. ACS Sensors, 2(7), 955-960. doi:10.1021/acssensors.7b00217 2379-3694 https://hdl.handle.net/10356/139094 10.1021/acssensors.7b00217 28750515 2-s2.0-85026372898 7 2 955 960 en NRF-CRP13-2014-01 NRF2014NRF-CRP001-002 ACS Sensors This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Sensors, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acssensors.7b00217 application/pdf |
| spellingShingle | Engineering::Electrical and electronic engineering Optofluidic Chip Microring Resonator Feng, Xueling Zhang, Gong Chin, Lip Ket Liu, Ai Qun Liedberg, Bo Highly sensitive, label-free detection of 2,4-dichlorophenoxyacetic acid using an optofluidic chip |
| title | Highly sensitive, label-free detection of 2,4-dichlorophenoxyacetic acid using an optofluidic chip |
| title_full | Highly sensitive, label-free detection of 2,4-dichlorophenoxyacetic acid using an optofluidic chip |
| title_fullStr | Highly sensitive, label-free detection of 2,4-dichlorophenoxyacetic acid using an optofluidic chip |
| title_full_unstemmed | Highly sensitive, label-free detection of 2,4-dichlorophenoxyacetic acid using an optofluidic chip |
| title_short | Highly sensitive, label-free detection of 2,4-dichlorophenoxyacetic acid using an optofluidic chip |
| title_sort | highly sensitive label free detection of 2 4 dichlorophenoxyacetic acid using an optofluidic chip |
| topic | Engineering::Electrical and electronic engineering Optofluidic Chip Microring Resonator |
| url | https://hdl.handle.net/10356/139094 |
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