Genetic discrimination between LADA and childhood-onset type 1 diabetes within the MHC
The MHC region harbors the strongest loci for latent autoimmune diabetes in adults (LADA); however, the strength of association is likely attenuated compared with that for childhood-onset type 1 diabetes. In this study, we recapitulate independent effects in the MHC class I region in a population wi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/139103 |
| _version_ | 1826113948808642560 |
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| author | Mishra, Rajashree Åkerlund, Mikael Cousminer, Diana L. Ahlqvist, Emma Bradfield, Jonathan P. Chesi, Alessandra Hodge, Kenyaita M. Guy, Vanessa C. Brillon, David J. Pratley, Richard E. Rickels, Michael R. Vella, Adrian Ovalle, Fernando Harris, Ronald I. Melander, Olle Varvel, Stephen Hakonarson, Hakon Froguel, Phillippe Lonsdale, John T. Mauricio, Didac Schloot, Nanette C. Khunti, Kamlesh Greenbaum, Carla J. Yderstræde, Knud B. Tuomi, Tiinamaija Voight, Benjamin F. Schwartz, Stanley Boehm, Bernhard Otto Groop, Leif Leslie, Richard David Grant, Struan F. A. |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Mishra, Rajashree Åkerlund, Mikael Cousminer, Diana L. Ahlqvist, Emma Bradfield, Jonathan P. Chesi, Alessandra Hodge, Kenyaita M. Guy, Vanessa C. Brillon, David J. Pratley, Richard E. Rickels, Michael R. Vella, Adrian Ovalle, Fernando Harris, Ronald I. Melander, Olle Varvel, Stephen Hakonarson, Hakon Froguel, Phillippe Lonsdale, John T. Mauricio, Didac Schloot, Nanette C. Khunti, Kamlesh Greenbaum, Carla J. Yderstræde, Knud B. Tuomi, Tiinamaija Voight, Benjamin F. Schwartz, Stanley Boehm, Bernhard Otto Groop, Leif Leslie, Richard David Grant, Struan F. A. |
| author_sort | Mishra, Rajashree |
| collection | NTU |
| description | The MHC region harbors the strongest loci for latent autoimmune diabetes in adults (LADA); however, the strength of association is likely attenuated compared with that for childhood-onset type 1 diabetes. In this study, we recapitulate independent effects in the MHC class I region in a population with type 1 diabetes and then determine whether such conditioning in LADA yields potential genetic discriminators between the two subtypes within this region. |
| first_indexed | 2024-10-01T03:31:12Z |
| format | Journal Article |
| id | ntu-10356/139103 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:31:12Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1391032020-11-01T05:14:09Z Genetic discrimination between LADA and childhood-onset type 1 diabetes within the MHC Mishra, Rajashree Åkerlund, Mikael Cousminer, Diana L. Ahlqvist, Emma Bradfield, Jonathan P. Chesi, Alessandra Hodge, Kenyaita M. Guy, Vanessa C. Brillon, David J. Pratley, Richard E. Rickels, Michael R. Vella, Adrian Ovalle, Fernando Harris, Ronald I. Melander, Olle Varvel, Stephen Hakonarson, Hakon Froguel, Phillippe Lonsdale, John T. Mauricio, Didac Schloot, Nanette C. Khunti, Kamlesh Greenbaum, Carla J. Yderstræde, Knud B. Tuomi, Tiinamaija Voight, Benjamin F. Schwartz, Stanley Boehm, Bernhard Otto Groop, Leif Leslie, Richard David Grant, Struan F. A. Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Type 1 Diabetes MHC The MHC region harbors the strongest loci for latent autoimmune diabetes in adults (LADA); however, the strength of association is likely attenuated compared with that for childhood-onset type 1 diabetes. In this study, we recapitulate independent effects in the MHC class I region in a population with type 1 diabetes and then determine whether such conditioning in LADA yields potential genetic discriminators between the two subtypes within this region. Accepted version 2020-05-15T07:33:07Z 2020-05-15T07:33:07Z 2020 Journal Article Mishra, R., Åkerlund, M., Cousminer, D. L., Ahlqvist, E., Bradfield, J. P., Chesi, A., . . ., Grant, S. F. A. (2020). Genetic discrimination between LADA and childhood-onset type 1 diabetes within the MHC. Diabetes care, 43(2), 418-425. doi:10.2337/dc19-0986 1935-5548 https://hdl.handle.net/10356/139103 10.2337/dc19-0986 31843946 2-s2.0-85078380035 2 43 418 425 en Diabetes care © 2019 American Diabetes Association (ADA). All rights reserved. This paper was published in Diabetes care and is made available with permission of American Diabetes Association (ADA). application/pdf |
| spellingShingle | Science::Medicine Type 1 Diabetes MHC Mishra, Rajashree Åkerlund, Mikael Cousminer, Diana L. Ahlqvist, Emma Bradfield, Jonathan P. Chesi, Alessandra Hodge, Kenyaita M. Guy, Vanessa C. Brillon, David J. Pratley, Richard E. Rickels, Michael R. Vella, Adrian Ovalle, Fernando Harris, Ronald I. Melander, Olle Varvel, Stephen Hakonarson, Hakon Froguel, Phillippe Lonsdale, John T. Mauricio, Didac Schloot, Nanette C. Khunti, Kamlesh Greenbaum, Carla J. Yderstræde, Knud B. Tuomi, Tiinamaija Voight, Benjamin F. Schwartz, Stanley Boehm, Bernhard Otto Groop, Leif Leslie, Richard David Grant, Struan F. A. Genetic discrimination between LADA and childhood-onset type 1 diabetes within the MHC |
| title | Genetic discrimination between LADA and childhood-onset type 1 diabetes within the MHC |
| title_full | Genetic discrimination between LADA and childhood-onset type 1 diabetes within the MHC |
| title_fullStr | Genetic discrimination between LADA and childhood-onset type 1 diabetes within the MHC |
| title_full_unstemmed | Genetic discrimination between LADA and childhood-onset type 1 diabetes within the MHC |
| title_short | Genetic discrimination between LADA and childhood-onset type 1 diabetes within the MHC |
| title_sort | genetic discrimination between lada and childhood onset type 1 diabetes within the mhc |
| topic | Science::Medicine Type 1 Diabetes MHC |
| url | https://hdl.handle.net/10356/139103 |
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