High-intensity focused ultrasound (HIFU) ablation by the frequency chirps : enhanced thermal field and cavitation at the focus
High-intensity focused ultrasound (HIFU) has become popular in the noninvasive ablation of a variety of solid tumors and cancers with promising clinical outcomes. Its ablation efficiency should be improved for the reduced treatment duration, especially for a large target. The frequency chirps were p...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | https://hdl.handle.net/10356/139118 |
| _version_ | 1811679683118366720 |
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| author | Wang, Mingjun Lei, Yisheng Zhou, Yufeng |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Wang, Mingjun Lei, Yisheng Zhou, Yufeng |
| author_sort | Wang, Mingjun |
| collection | NTU |
| description | High-intensity focused ultrasound (HIFU) has become popular in the noninvasive ablation of a variety of solid tumors and cancers with promising clinical outcomes. Its ablation efficiency should be improved for the reduced treatment duration, especially for a large target. The frequency chirps were proposed and investigated for the enhanced lesion production and bubble cavitation at the focus during HIFU ablation. First, a nonlinear wave model was used to simulate the acoustic field using different excitation strategies (at the constant frequency excitation, downward and upward frequency chirps) and subsequently, the bubble dynamics and cavitation-enhanced temperature elevation were calculated by the Gilmore and Bioheat equations, respectively. Then the temperature rises and the produced lesion in the gel phantom were measured by the thermocouple and recorded photographically, respectively. Bubble activities at the focus were measured by passive cavitation detection (PCD) to quantify the scattering and inertial cavitation levels using short-time Fourier-transform (STFT). Finally, the enhanced temperature elevation, lesion production, and bubble cavitation were further confirmed in the ex vivo tissue samples. It is found that the frequency sweeping time plays a more important role in the enhancement of HIFU-produced lesion in the gel phantom while the frequency sweeping range seems more critical in the tissue. Altogether, large frequency sweeping range in a short time is preferable, and the frequency sweeping direction has little influence on the lesion enhancement. |
| first_indexed | 2024-10-01T03:13:03Z |
| format | Journal Article |
| id | ntu-10356/139118 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:13:03Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1391182023-03-04T17:25:48Z High-intensity focused ultrasound (HIFU) ablation by the frequency chirps : enhanced thermal field and cavitation at the focus Wang, Mingjun Lei, Yisheng Zhou, Yufeng School of Mechanical and Aerospace Engineering Engineering::Mechanical engineering High-intensity Focused Ultrasound Frequency Chirp Excitation High-intensity focused ultrasound (HIFU) has become popular in the noninvasive ablation of a variety of solid tumors and cancers with promising clinical outcomes. Its ablation efficiency should be improved for the reduced treatment duration, especially for a large target. The frequency chirps were proposed and investigated for the enhanced lesion production and bubble cavitation at the focus during HIFU ablation. First, a nonlinear wave model was used to simulate the acoustic field using different excitation strategies (at the constant frequency excitation, downward and upward frequency chirps) and subsequently, the bubble dynamics and cavitation-enhanced temperature elevation were calculated by the Gilmore and Bioheat equations, respectively. Then the temperature rises and the produced lesion in the gel phantom were measured by the thermocouple and recorded photographically, respectively. Bubble activities at the focus were measured by passive cavitation detection (PCD) to quantify the scattering and inertial cavitation levels using short-time Fourier-transform (STFT). Finally, the enhanced temperature elevation, lesion production, and bubble cavitation were further confirmed in the ex vivo tissue samples. It is found that the frequency sweeping time plays a more important role in the enhancement of HIFU-produced lesion in the gel phantom while the frequency sweeping range seems more critical in the tissue. Altogether, large frequency sweeping range in a short time is preferable, and the frequency sweeping direction has little influence on the lesion enhancement. Accepted version 2020-05-15T08:39:24Z 2020-05-15T08:39:24Z 2019 Journal Article Wang, M., Lei, Y., & Zhou, Y. (2019). High-intensity focused ultrasound (HIFU) ablation by the frequency chirps : enhanced thermal field and cavitation at the focus. Ultrasonics, 91, 134-149. doi:10.1016/j.ultras.2018.08.017 0041-624X https://hdl.handle.net/10356/139118 10.1016/j.ultras.2018.08.017 30146323 2-s2.0-85052069003 91 134 149 en Ultrasonics © 2018 Elsevier B.V. All rights reserved. This paper was published in Ultrasonics and is made available with permission of Elsevier B.V. application/pdf |
| spellingShingle | Engineering::Mechanical engineering High-intensity Focused Ultrasound Frequency Chirp Excitation Wang, Mingjun Lei, Yisheng Zhou, Yufeng High-intensity focused ultrasound (HIFU) ablation by the frequency chirps : enhanced thermal field and cavitation at the focus |
| title | High-intensity focused ultrasound (HIFU) ablation by the frequency chirps : enhanced thermal field and cavitation at the focus |
| title_full | High-intensity focused ultrasound (HIFU) ablation by the frequency chirps : enhanced thermal field and cavitation at the focus |
| title_fullStr | High-intensity focused ultrasound (HIFU) ablation by the frequency chirps : enhanced thermal field and cavitation at the focus |
| title_full_unstemmed | High-intensity focused ultrasound (HIFU) ablation by the frequency chirps : enhanced thermal field and cavitation at the focus |
| title_short | High-intensity focused ultrasound (HIFU) ablation by the frequency chirps : enhanced thermal field and cavitation at the focus |
| title_sort | high intensity focused ultrasound hifu ablation by the frequency chirps enhanced thermal field and cavitation at the focus |
| topic | Engineering::Mechanical engineering High-intensity Focused Ultrasound Frequency Chirp Excitation |
| url | https://hdl.handle.net/10356/139118 |
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