Synthesis of novel drug-free cancer targeting nanotherapeutics
Cancer remains the leading cause of death worldwide. Mesoporous silica nanoparticles (MSNs) are seen as one of the promising candidates for anti-cancer therapy, due to its favourable cancer-killing properties. In this research paper, MSNs are being further modified, through attachment of PEG (Polyet...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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Nanyang Technological University
2020
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| Online Access: | https://hdl.handle.net/10356/139298 |
| _version_ | 1826113883269496832 |
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| author | Cheong, How Min |
| author2 | Dalton Tay Chor Yong |
| author_facet | Dalton Tay Chor Yong Cheong, How Min |
| author_sort | Cheong, How Min |
| collection | NTU |
| description | Cancer remains the leading cause of death worldwide. Mesoporous silica nanoparticles (MSNs) are seen as one of the promising candidates for anti-cancer therapy, due to its favourable cancer-killing properties. In this research paper, MSNs are being further modified, through attachment of PEG (Polyethylene Glycol) chains, in efforts to increase its ability to cause cancer cell death in-vivo, by reducing aggregation and therefore increasing the stability of MSNs. Preliminary in vitro results indicate that PEG conjugation can significantly enhance the stability of MSN in water as well as physiologically-emulated phosphate-buffered saline (PBS). These data lay a solid foundation for the follow-up fabrication of cancer-targeting physiologically-stable silica nanomedicine. |
| first_indexed | 2024-10-01T03:30:31Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/139298 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:30:31Z |
| publishDate | 2020 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1392982023-03-04T15:48:23Z Synthesis of novel drug-free cancer targeting nanotherapeutics Cheong, How Min Dalton Tay Chor Yong School of Materials Science and Engineering cytay@ntu.edu.sg Engineering::Materials::Biomaterials Cancer remains the leading cause of death worldwide. Mesoporous silica nanoparticles (MSNs) are seen as one of the promising candidates for anti-cancer therapy, due to its favourable cancer-killing properties. In this research paper, MSNs are being further modified, through attachment of PEG (Polyethylene Glycol) chains, in efforts to increase its ability to cause cancer cell death in-vivo, by reducing aggregation and therefore increasing the stability of MSNs. Preliminary in vitro results indicate that PEG conjugation can significantly enhance the stability of MSN in water as well as physiologically-emulated phosphate-buffered saline (PBS). These data lay a solid foundation for the follow-up fabrication of cancer-targeting physiologically-stable silica nanomedicine. Bachelor of Engineering (Materials Engineering) 2020-05-18T10:45:58Z 2020-05-18T10:45:58Z 2020 Final Year Project (FYP) https://hdl.handle.net/10356/139298 en application/pdf Nanyang Technological University |
| spellingShingle | Engineering::Materials::Biomaterials Cheong, How Min Synthesis of novel drug-free cancer targeting nanotherapeutics |
| title | Synthesis of novel drug-free cancer targeting nanotherapeutics |
| title_full | Synthesis of novel drug-free cancer targeting nanotherapeutics |
| title_fullStr | Synthesis of novel drug-free cancer targeting nanotherapeutics |
| title_full_unstemmed | Synthesis of novel drug-free cancer targeting nanotherapeutics |
| title_short | Synthesis of novel drug-free cancer targeting nanotherapeutics |
| title_sort | synthesis of novel drug free cancer targeting nanotherapeutics |
| topic | Engineering::Materials::Biomaterials |
| url | https://hdl.handle.net/10356/139298 |
| work_keys_str_mv | AT cheonghowmin synthesisofnoveldrugfreecancertargetingnanotherapeutics |