A catalytic and selective scissoring molecular tool for quadruplex nucleic acids
A copper complex embedded in the structure of a water-soluble naphthalene diimide has been designed to bind and cleave G-quadruplex DNA. We describe the properties of this ligand, including its catalytic activity in the generation of ROS. FRET melting, CD, NMR, gel sequencing, and mass spectrometry...
Main Authors: | Nadai, Matteo, Doria, Filippo, Scalabrin, Matteo, Pirota, Valentina, Grande, Vincenzo, Bergamaschi, Greta, Amendola, Valeria, Winnerdy, Fernaldo Richtia, Phan, Anh Tuân, Richter, Sara N., Freccero, Mauro |
---|---|
Other Authors: | School of Physical and Mathematical Sciences |
Format: | Journal Article |
Language: | English |
Published: |
2020
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/139320 |
Similar Items
-
Development and application of NMR spectroscopy in G-quadruplexes : structure, dynamics and formation in biofilm
by: Winnerdy, Fernaldo Richtia
Published: (2019) -
Copper-based catalysts supported on nitrogen-doped reduced graphite oxide for dehydrogenation of cyclohexanol to cyclohexanone
by: Mageed, Alyaa Khadhier
Published: (2017) -
An unprecedented knot‐like G‐quadruplex peripheral motif
by: Truong, Thi Hong Anh, et al.
Published: (2020) -
Solution structures of a G-quadruplex bound to linear- and cyclic-dinucleotides
by: Winnerdy, Fernaldo Richtia, et al.
Published: (2020) -
Comparison of yield and chemical composition of essential oils from lemongrass (Cymbopogon Citratus) extracted with Microwave-Assisted Hydrodistillation (MAHD) and Conventional Hydrodistillation (HD) methods / Ranitha. M....[et al.]
by: M., Ranitha., et al.
Published: (2014)