Small-intestine-specific delivery of antidiabetic extracts from withania coagulans using polysaccharide-based enteric-coated nanoparticles
Withania coagulans is an Indian medicinal herb, the natural extracts of which are purported to have health-benefiting properties. In this study, the extract was encapsulated in nature-derived polymers with the aim of enhancing its bioavailability. The aqueous extract obtained from the plant W. coagu...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | https://hdl.handle.net/10356/139324 |
| _version_ | 1826109947467792384 |
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| author | Sampathkumar, Kaarunya Riyajan, Siriporn Tan, Chiew Kei Demokritou, Philip Chudapongse, Nuannoi Loo, Joachim Say Chye |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Sampathkumar, Kaarunya Riyajan, Siriporn Tan, Chiew Kei Demokritou, Philip Chudapongse, Nuannoi Loo, Joachim Say Chye |
| author_sort | Sampathkumar, Kaarunya |
| collection | NTU |
| description | Withania coagulans is an Indian medicinal herb, the natural extracts of which are purported to have health-benefiting properties. In this study, the extract was encapsulated in nature-derived polymers with the aim of enhancing its bioavailability. The aqueous extract obtained from the plant W. coagulans was found to elicit the glucose-lowering effect by means of promoting insulin secretion from pancreatic β cells. The cells treated with the extract showed a nearly 2-fold increase in insulin secretion compared to untreated cells. A delivery system for the extract was developed based on electrosprayed chitosan nanoparticles coated with food-based starch. The enteric starch coating retarded (by 2.5 times) the release of the extract in the stomach. The bioactivity of the encapsulated extract was subsequently tested in vitro on mouse-derived pancreatic β cells, whereby the delivery system was found to promote insulin secretion. Finally, the extract-encapsulated oral delivery system was tested on diabetic mice and was validated to decrease blood glucose levels by 60%. In summary, it could be inferred that food-grade enteric-coated polysaccharide-based particles increase the bioavailability of the extracted compounds from the plant W. coagulans. |
| first_indexed | 2024-10-01T02:26:26Z |
| format | Journal Article |
| id | ntu-10356/139324 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:26:26Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1393242023-07-14T16:04:22Z Small-intestine-specific delivery of antidiabetic extracts from withania coagulans using polysaccharide-based enteric-coated nanoparticles Sampathkumar, Kaarunya Riyajan, Siriporn Tan, Chiew Kei Demokritou, Philip Chudapongse, Nuannoi Loo, Joachim Say Chye School of Materials Science & Engineering Singapore Centre for Environmental Life Sciences and Engineering Engineering::Materials Chitosan Delivery System Withania coagulans is an Indian medicinal herb, the natural extracts of which are purported to have health-benefiting properties. In this study, the extract was encapsulated in nature-derived polymers with the aim of enhancing its bioavailability. The aqueous extract obtained from the plant W. coagulans was found to elicit the glucose-lowering effect by means of promoting insulin secretion from pancreatic β cells. The cells treated with the extract showed a nearly 2-fold increase in insulin secretion compared to untreated cells. A delivery system for the extract was developed based on electrosprayed chitosan nanoparticles coated with food-based starch. The enteric starch coating retarded (by 2.5 times) the release of the extract in the stomach. The bioactivity of the encapsulated extract was subsequently tested in vitro on mouse-derived pancreatic β cells, whereby the delivery system was found to promote insulin secretion. Finally, the extract-encapsulated oral delivery system was tested on diabetic mice and was validated to decrease blood glucose levels by 60%. In summary, it could be inferred that food-grade enteric-coated polysaccharide-based particles increase the bioavailability of the extracted compounds from the plant W. coagulans. MOE (Min. of Education, S’pore) Published version 2020-05-19T01:38:53Z 2020-05-19T01:38:53Z 2019 Journal Article Sampathkumar, K., Riyajan, S., Tan, C. K., Demokritou, P., Chudapongse, N., & Loo, J. S. C. (2019). Small-intestine-specific delivery of antidiabetic extracts from withania coagulans using polysaccharide-based enteric-coated nanoparticles. ACS omega, 4(7), 12049–12057. doi:10.1021/acsomega.9b00823 2470-1343 https://hdl.handle.net/10356/139324 10.1021/acsomega.9b00823 31460318 2-s2.0-85076731434 7 4 12049 12057 en ACS omega © 2019 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. application/pdf |
| spellingShingle | Engineering::Materials Chitosan Delivery System Sampathkumar, Kaarunya Riyajan, Siriporn Tan, Chiew Kei Demokritou, Philip Chudapongse, Nuannoi Loo, Joachim Say Chye Small-intestine-specific delivery of antidiabetic extracts from withania coagulans using polysaccharide-based enteric-coated nanoparticles |
| title | Small-intestine-specific delivery of antidiabetic extracts from withania coagulans using polysaccharide-based enteric-coated nanoparticles |
| title_full | Small-intestine-specific delivery of antidiabetic extracts from withania coagulans using polysaccharide-based enteric-coated nanoparticles |
| title_fullStr | Small-intestine-specific delivery of antidiabetic extracts from withania coagulans using polysaccharide-based enteric-coated nanoparticles |
| title_full_unstemmed | Small-intestine-specific delivery of antidiabetic extracts from withania coagulans using polysaccharide-based enteric-coated nanoparticles |
| title_short | Small-intestine-specific delivery of antidiabetic extracts from withania coagulans using polysaccharide-based enteric-coated nanoparticles |
| title_sort | small intestine specific delivery of antidiabetic extracts from withania coagulans using polysaccharide based enteric coated nanoparticles |
| topic | Engineering::Materials Chitosan Delivery System |
| url | https://hdl.handle.net/10356/139324 |
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