Bioadhesives for internal medical applications : a review
Bioadhesives such as tissue adhesives, hemostatic agents, and tissue sealants have gained increasing popularity in different areas of clinical operations during the last three decades. Bioadhesives can be categorized into internal and external ones according to their application conditions. External...
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| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | https://hdl.handle.net/10356/139488 |
| _version_ | 1811695576947884032 |
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| author | Zhu, Wenzhen Chuah, Yon Jin Wang, Dong-An |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Zhu, Wenzhen Chuah, Yon Jin Wang, Dong-An |
| author_sort | Zhu, Wenzhen |
| collection | NTU |
| description | Bioadhesives such as tissue adhesives, hemostatic agents, and tissue sealants have gained increasing popularity in different areas of clinical operations during the last three decades. Bioadhesives can be categorized into internal and external ones according to their application conditions. External bioadhesives are generally applied in topical medications such as wound closure and epidermal grafting. Internal bioadhesives are mainly used in intracorporal conditions with direct contact to internal environment including tissues, organs and body fluids, such as chronic organ leak repair and bleeding complication reduction. This review focuses on internal bioadhesives that, in contrast with external bioadhesives, emphasize much more on biocompatibility and adhesive ability to wet surfaces rather than on gluing time and intensity. The crosslinking mechanisms of present internal bioadhesives can be generally classified as follows: 1) chemical conjugation between reactive groups; 2) free radical polymerization by light or redox initiation; 3) biological or biochemical coupling with specificity; and 4) biomimetic adhesion inspired from natural phenomena. In this review, bioadhesive products of each class are summarized and discussed by comparing their designs, features, and applications as well as their prospects for future development. |
| first_indexed | 2024-10-01T07:25:40Z |
| format | Journal Article |
| id | ntu-10356/139488 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:25:40Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1394882020-06-01T10:01:35Z Bioadhesives for internal medical applications : a review Zhu, Wenzhen Chuah, Yon Jin Wang, Dong-An School of Chemical and Biomedical Engineering School of Materials Science & Engineering Engineering::Bioengineering Bioadhesive Tissue Adhesive Bioadhesives such as tissue adhesives, hemostatic agents, and tissue sealants have gained increasing popularity in different areas of clinical operations during the last three decades. Bioadhesives can be categorized into internal and external ones according to their application conditions. External bioadhesives are generally applied in topical medications such as wound closure and epidermal grafting. Internal bioadhesives are mainly used in intracorporal conditions with direct contact to internal environment including tissues, organs and body fluids, such as chronic organ leak repair and bleeding complication reduction. This review focuses on internal bioadhesives that, in contrast with external bioadhesives, emphasize much more on biocompatibility and adhesive ability to wet surfaces rather than on gluing time and intensity. The crosslinking mechanisms of present internal bioadhesives can be generally classified as follows: 1) chemical conjugation between reactive groups; 2) free radical polymerization by light or redox initiation; 3) biological or biochemical coupling with specificity; and 4) biomimetic adhesion inspired from natural phenomena. In this review, bioadhesive products of each class are summarized and discussed by comparing their designs, features, and applications as well as their prospects for future development. 2020-05-20T01:27:53Z 2020-05-20T01:27:53Z 2018 Journal Article Zhu, W., Chuah, Y. J., & Wang, D.-A. (2018). Bioadhesives for internal medical applications : a review. Acta Biomaterialia, 74, 1-16. doi:10.1016/j.actbio.2018.04.034 1742-7061 https://hdl.handle.net/10356/139488 10.1016/j.actbio.2018.04.034 29684627 2-s2.0-85046138137 74 1 16 en Acta Biomaterialia © 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| spellingShingle | Engineering::Bioengineering Bioadhesive Tissue Adhesive Zhu, Wenzhen Chuah, Yon Jin Wang, Dong-An Bioadhesives for internal medical applications : a review |
| title | Bioadhesives for internal medical applications : a review |
| title_full | Bioadhesives for internal medical applications : a review |
| title_fullStr | Bioadhesives for internal medical applications : a review |
| title_full_unstemmed | Bioadhesives for internal medical applications : a review |
| title_short | Bioadhesives for internal medical applications : a review |
| title_sort | bioadhesives for internal medical applications a review |
| topic | Engineering::Bioengineering Bioadhesive Tissue Adhesive |
| url | https://hdl.handle.net/10356/139488 |
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