Adaptor protein WDFY3 is neuroprotective by counteracting age-dependent decline in proteostasis

Age-dependent decline in proteostasis increases vulnerability of neuronal cells to oxidative stress, altered energy homeostasis and protein aggregation. Recent studies have suggested an adaptor role for BEACH-domain containing proteins (BDCPs) in autophagy-mediated clearance of protein aggregates in...

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Dettagli Bibliografici
Autore principale: Fun, Xiu Hui
Altri autori: Guillaume Thibault
Natura: Thesis-Doctor of Philosophy
Lingua:English
Pubblicazione: Nanyang Technological University 2020
Soggetti:
Accesso online:https://hdl.handle.net/10356/139649