Adaptor protein WDFY3 is neuroprotective by counteracting age-dependent decline in proteostasis
Age-dependent decline in proteostasis increases vulnerability of neuronal cells to oxidative stress, altered energy homeostasis and protein aggregation. Recent studies have suggested an adaptor role for BEACH-domain containing proteins (BDCPs) in autophagy-mediated clearance of protein aggregates in...
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| Formato: | Thesis-Doctor of Philosophy |
| Lenguaje: | English |
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Nanyang Technological University
2020
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| Acceso en línea: | https://hdl.handle.net/10356/139649 |