Adaptor protein WDFY3 is neuroprotective by counteracting age-dependent decline in proteostasis

Age-dependent decline in proteostasis increases vulnerability of neuronal cells to oxidative stress, altered energy homeostasis and protein aggregation. Recent studies have suggested an adaptor role for BEACH-domain containing proteins (BDCPs) in autophagy-mediated clearance of protein aggregates in...

Повний опис

Бібліографічні деталі
Автор: Fun, Xiu Hui
Інші автори: Guillaume Thibault
Формат: Thesis-Doctor of Philosophy
Мова:English
Опубліковано: Nanyang Technological University 2020
Предмети:
Онлайн доступ:https://hdl.handle.net/10356/139649