Autophagy as a cellular stress response mechanism in the nervous system
Cells of an organism face with various types of insults during their lifetime. Exposure to toxins, metabolic problems, ischaemia/reperfusion, physical trauma, genetic diseases, neurodegenerative diseases are among the conditions that trigger cellular stress responses. In this context, autophagy is o...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/139716 |
| _version_ | 1811688288620118016 |
|---|---|
| author | Peker, Nesibe Gozuacik, Devrim |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Peker, Nesibe Gozuacik, Devrim |
| author_sort | Peker, Nesibe |
| collection | NTU |
| description | Cells of an organism face with various types of insults during their lifetime. Exposure to toxins, metabolic problems, ischaemia/reperfusion, physical trauma, genetic diseases, neurodegenerative diseases are among the conditions that trigger cellular stress responses. In this context, autophagy is one of the mechanisms that supports cell survival under stressful conditions. Autophagic vesicle engulfs the cargo and transports it to lysosome for degradation and turnover. As such, autophagy eliminates abnormal proteins, clears damaged organelles, limits oxidative stress and helps to improve metabolic balance. Nervous system cells and particularly postmitotic neurons are highly sensitive to a spectrum of insults, and autophagy emerges as one of the key stress response mechanism, ensuring health and survival of these vulnerable cell types. In this review, we will overview mechanisms through which cells cope with stress, and how these stress responses regulate autophagy, with a special focus on the nervous system. |
| first_indexed | 2024-10-01T05:29:50Z |
| format | Journal Article |
| id | ntu-10356/139716 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:29:50Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1397162020-05-21T04:43:18Z Autophagy as a cellular stress response mechanism in the nervous system Peker, Nesibe Gozuacik, Devrim School of Biological Sciences Science::Biological sciences Autophagy Cellular Stress Cells of an organism face with various types of insults during their lifetime. Exposure to toxins, metabolic problems, ischaemia/reperfusion, physical trauma, genetic diseases, neurodegenerative diseases are among the conditions that trigger cellular stress responses. In this context, autophagy is one of the mechanisms that supports cell survival under stressful conditions. Autophagic vesicle engulfs the cargo and transports it to lysosome for degradation and turnover. As such, autophagy eliminates abnormal proteins, clears damaged organelles, limits oxidative stress and helps to improve metabolic balance. Nervous system cells and particularly postmitotic neurons are highly sensitive to a spectrum of insults, and autophagy emerges as one of the key stress response mechanism, ensuring health and survival of these vulnerable cell types. In this review, we will overview mechanisms through which cells cope with stress, and how these stress responses regulate autophagy, with a special focus on the nervous system. 2020-05-21T04:43:18Z 2020-05-21T04:43:18Z 2020 Journal Article Peker, N., & Gozuacik, D. (2020).Autophagy as a cellular stress response mechanism in the nervous system. Journal of molecular biology, 432(8), 2560-2588. doi:10.1016/j.jmb.2020.01.017 0022-2836 https://hdl.handle.net/10356/139716 10.1016/j.jmb.2020.01.017 31962122 2-s2.0-85078832016 8 432 2560 2588 en Journal of molecular biology © 2020 Elsevier Ltd. All rights reserved. |
| spellingShingle | Science::Biological sciences Autophagy Cellular Stress Peker, Nesibe Gozuacik, Devrim Autophagy as a cellular stress response mechanism in the nervous system |
| title | Autophagy as a cellular stress response mechanism in the nervous system |
| title_full | Autophagy as a cellular stress response mechanism in the nervous system |
| title_fullStr | Autophagy as a cellular stress response mechanism in the nervous system |
| title_full_unstemmed | Autophagy as a cellular stress response mechanism in the nervous system |
| title_short | Autophagy as a cellular stress response mechanism in the nervous system |
| title_sort | autophagy as a cellular stress response mechanism in the nervous system |
| topic | Science::Biological sciences Autophagy Cellular Stress |
| url | https://hdl.handle.net/10356/139716 |
| work_keys_str_mv | AT pekernesibe autophagyasacellularstressresponsemechanisminthenervoussystem AT gozuacikdevrim autophagyasacellularstressresponsemechanisminthenervoussystem |