Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes
A three-dimensional conjugated oligoelectrolyte (COE) bearing a [2.2]paracyclophane unit (COE2-3-pCp) was synthesized. Its biological activity was determined both in vivo and in silicon within the context of membrane perturbation and biocompatibility. Molecular dynamics simulations indicate that, co...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/140615 |
| _version_ | 1826126555424751616 |
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| author | Limwongyut, Jakarin Liu, Yang Chilambi, Gayatri Shankar Seviour, Thomas Hinks, Jamie Mu, Yuguang Bazan, Guillermo C. |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Limwongyut, Jakarin Liu, Yang Chilambi, Gayatri Shankar Seviour, Thomas Hinks, Jamie Mu, Yuguang Bazan, Guillermo C. |
| author_sort | Limwongyut, Jakarin |
| collection | NTU |
| description | A three-dimensional conjugated oligoelectrolyte (COE) bearing a [2.2]paracyclophane unit (COE2-3-pCp) was synthesized. Its biological activity was determined both in vivo and in silicon within the context of membrane perturbation and biocompatibility. Molecular dynamics simulations indicate that, compared to its linear analog (COE2-3C), COE2-3-pCp introduces more lipid disorder with higher extent of membrane thinning. COE2-3-pCp also exhibits a higher MIC towards E. coli K12 and yeast, while maintaining similar levels of membrane permeabilization. These findings suggest a new design of COEs as biocompatible cell permeabilizers. |
| first_indexed | 2024-10-01T06:54:34Z |
| format | Journal Article |
| id | ntu-10356/140615 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:54:34Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1406152023-12-29T06:51:26Z Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes Limwongyut, Jakarin Liu, Yang Chilambi, Gayatri Shankar Seviour, Thomas Hinks, Jamie Mu, Yuguang Bazan, Guillermo C. School of Chemical and Biomedical Engineering School of Biological Sciences Singapore Centre for Environmental Life Sciences and Engineering Engineering::Bioengineering Conjugated Oligoelectrolyte Biological Membranes A three-dimensional conjugated oligoelectrolyte (COE) bearing a [2.2]paracyclophane unit (COE2-3-pCp) was synthesized. Its biological activity was determined both in vivo and in silicon within the context of membrane perturbation and biocompatibility. Molecular dynamics simulations indicate that, compared to its linear analog (COE2-3C), COE2-3-pCp introduces more lipid disorder with higher extent of membrane thinning. COE2-3-pCp also exhibits a higher MIC towards E. coli K12 and yeast, while maintaining similar levels of membrane permeabilization. These findings suggest a new design of COEs as biocompatible cell permeabilizers. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) Published version 2020-06-01T02:17:11Z 2020-06-01T02:17:11Z 2018 Journal Article Limwongyut, J., Liu, Y., Chilambi, G. S., Seviour, T., Hinks, J., Mu, Y., & Bazan, G. C. (2018). Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes. RSC Advances, 8(70), 39849-39853. doi:10.1039/c8ra08069k 2046-2069 https://hdl.handle.net/10356/140615 10.1039/C8RA08069K 2-s2.0-85058232604 70 8 39849 39853 en RSC Advances © 2018 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. application/pdf |
| spellingShingle | Engineering::Bioengineering Conjugated Oligoelectrolyte Biological Membranes Limwongyut, Jakarin Liu, Yang Chilambi, Gayatri Shankar Seviour, Thomas Hinks, Jamie Mu, Yuguang Bazan, Guillermo C. Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes |
| title | Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes |
| title_full | Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes |
| title_fullStr | Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes |
| title_full_unstemmed | Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes |
| title_short | Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes |
| title_sort | interactions of a paracyclophane based conjugated oligoelectrolyte with biological membranes |
| topic | Engineering::Bioengineering Conjugated Oligoelectrolyte Biological Membranes |
| url | https://hdl.handle.net/10356/140615 |
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